Publications by authors named "Musharraf N Khan"
Article Synopsis
- Matuzumab and nimotuzumab are anti-EGFR monoclonal antibodies that target different parts of the EGFR protein, and Zr-matuzumab was developed as a PET imaging probe for tracking treatment effectiveness in mouse models of colorectal cancer.
- Quality control tests showed that Zr-matuzumab binds effectively to EGFR-positive cells, with specific binding affinities measured for matuzumab and its derivatives.
- When tested in mice, Zr-matuzumab imaging confirmed it binds specifically to EGFR-positive tumors, while treatment with the nimotuzumab-PEG-DM1 antibody drug conjugate showed promising results, leading to tumor remission in some cases.
Pyridines have been formed by heating azabicyclo[3.2.0]hept-2-en-4-ones in toluene.
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