TUMOR INFILTRATING LYMPHOCYTES PECULIARITIES IN DIFFERENT HISTOPATHOLOGICAL AND MOLECULAR SUBTYPES OF GASTRIC CARCINOMA.

Gastric carcinoma represents one of the major causes of cancer related mortality worldwide. Recently, immunotherapeutic means gave the new promise for the treatment of gastric carcinoma, although, not all patients benefit from this type of treatment. Tumor infiltrating lymphocytes (TILs) are considered as one of the promising prognostic and predictive biomarkers in solid tumors.

THE STUDY OF THE EXPRESSION OF CDH1, KI67, P53 AND HER2 IN DIFFUSE GASTRIC CARCINOMA.

Gastric cancer represents the fifth most common malignancy and third most common cause of cancer deaths worldwide. There are two major types of gastric carcinoma: enteric type and diffuse type. Diffuse type gastric cancer is frequently associated with the mutations in E-cadherin coding gene CDH1.

[State of the hypothalamo-hypophyseal-ovarian system in young nullipara women with ectopia of the cervix of uterus during taking the hormonal contraceptives].

Background diseases of the cervix of the uterus play one of the leading roles in the structure of gynecological pathology and present the risk of the development precancerous changes. Ectopia is observed in the structure of precancerous processes of the cervix of the uterus in 38, 8% of women and in 42, 2% cases of gynecological diseases. Our aim is to investigate the content of gonadotropic and steroid hormones in the blood plasma of young nullipara women with different types of ectopia during taking hormonal contraceptives.

[Hormonal contraception and cervix of the uterus pathology].

The effect of hormonal contraception on cervix of the uterus of young nullipara women with ectopia was investigated. Cohort study was carried out by using simple blind method. By means of statistical data manipulation correlation between the application of hormonal contraceptives and changes of colposcopy pictures in the zone of pathology was displayed.

[Ectopia of cervix of the uterus and hormonal contraception].

The aim of the study was the investigation of impact of different hormonal contraceptive drugs on cervix of uterus of young nullipara women with ectopia. Cytologic smears were examined using Pappanikolau method. Cohort study was carried out by using simple blind method.

[The immunohistochemical characteristics of cervical glandular intraepithelial neoplasias].

The aim of our study was to identify immunohistochemical diagnostic criteria for cervical glandular intraepithelial neoplasias (CGIN). We examined 136 women with cytological diagnosis of atypical endocervical cells. These patients were divided into three groups based on a grade of the lesion: 35 patients with CGIN1 (group I), 72 patients with CGIN2 (group II), 28 patients with CGIN3 (group III).

[Histological and morphological characteristics of the different stages of cervical glandular intraepithelial neoplasia].

Currently there is no world system classification of glandular hyperplasia of uterine cervix (endocervix). Different authors give nonmonosemantic estimations to each type of cervical hyperplasia. Cervical Glandular Intraepithelial Neoplasia (CGIN) or Glandular Dysplasia is considered as a precancerous lesion of endocervix.

[Oxidative processes in the cervical and vaginal epithelial tissue in patients with HPV infection].

Genital human papilloma virus (HPV) infection is the sexually transmitted disease. HPV induces the proliferation of epithelial cells. In the areas of viral inclusions vulvovaginal warts, papillomas and condylomas are developing.

[Determination of cytomorphological criteria for differential diagnostics of variable stages of endocervical glandular cells atypia].

The aim of the investigation was to determine the criteria of differential diagnostics of different stages atypia of endocervical cells in women of different age groups. For ECCIN3, out of 12 diagnostic criteria, the most important and statistically significant were the following five: a) high N/C index > 5,54; b) number of mitoses > 10,3; c) number of produced rosettes >3,9; d) rough redistribution of chromatin >4,64; e) hyperchromatosis >1,87. In case of ECCIN3 the majority of patients (82,75%) had infection of the cervix.