[Impaired maternal and fetal hemodynamics in the pathogenesis of gestosis].

The study was undertaken to examine the specific features of maternal and fetal hemodynamics in the pathogenesis of gestosis and to develop differential approaches to obstetric policy. For this, a total of 345 pregnant women at risk for gestosis were examined. This condition was prevented using aspirin and trental in 60 women.

[Pathogenesis of systemic hemodynamic disorders and choice of optimal obstetrical strategy in pregnant patients with gestosis].

A total of 810 pregnant women were examined in order to elucidate the pathogenesis of hemodynamic disorders in gestosis. The main group consisted of 460 patients with gestosis of different severity and the control group included 150 women with uneventful pregnancy. Central and regional hemodynamics in normal pregnancy were studied in detail by modern diagnostic methods (echocardiography and dopplerometry) and the relationship between the detected shifts and the function of the utero-placento-fetal circulation was shown.

[Central and regional hemodynamics during the physiological course of pregnancy and the systemic circulatory disorders in gestoses].

Ninety-one patients with physiological pregnancy and gestosis were studied. This included examinations of maternal central hemodynamics and Doppler study of blood flow in the system of carotids, renal artery and its branches, uterine and umbilical arteries. The volumetric maternal central hemodynamic parameters were found to increase concurrently with a reduction in peripheral vascular resistance during physiological pregnancy, which is associated with the emergence and development of a fetoplacental complex.

[The clinico-diagnostic importance of evaluating the blood flow in the mother-placenta-fetus system in EPH gestosis].

A dynamic dopplerometry of the blood flow in the mother-placenta-fetus system, carried out in 79 women with EPH gestosis, revealed a direct correlation between uteroplacental and fetoplacental blood flow disturbances and gestosis, hypertension, edematous syndrome, and proteinuria severity. Comprehensive assessment of the blood flow in both uterine arteries and umbilical artery are preferable. When third-degree circulatory disturbances are revealed in the mother-placenta-fetus system, cesarean section is recommended.

[Value of utero-placental and feto-placental Doppler flowmetry in selecting rational tactics in the management of pregnancy and the method of delivery].

A classification of hemodynamic disorders in the mother-placenta-fetus system has been developed, and approaches to the management of pregnancy and the choice of the method and time of delivery have been evolved on the basis of a study of 134 normal pregnancies and 47 complicated pregnancies between 16 and 41 weeks. It is demonstrated that abdominal delivery is preferable for the sake of the fetus where uteroplacental and fetoplacental circulatory disturbances are considerable.

[Pathophysiologic role of the level of taste sensitivity to table salt and its determination during treatment of hypertension with diuretics].

Sixty hypertensive patients (stage IIB, no complications) were studied. Gustatory sensitivity threshold to salt was determined and body fluid volume, extracellular fluid volume, intracellular fluid volume, circulating plasma volume and interstitial fluid volume were measured in the control period and 2-3 weeks after treatment with diuretics. 27, 63 and 10% of patients had low, moderate and high gustatory sensitivity threshold, respectively.

[Changes in body fluid spaces in hypertension patients treated with different diuretics].

Body fluid spaces: total body fluid volume, extracellular fluid volume, circulating plasma volume, intracellular and interstitial fluid volumes were studied in 60 patients with essential hypertension, stage IIB. The studies were performed prior and following a two-week treatment with diuretics ( furosemid , oxodolin , hydrochlorothiazide, brinaldix ). The patients were divided into 3 groups.

[Affinity chromatography and properties of cGMP-dependent protein kinase from prawn tissues].

Using affinity chromatography on 8-(2-aminoethyl)-amino-cAMP Sepharose, the cGMP-dependent protein kinase (ATP: protein phosphotransferase, EC 2.7.1.

[Determination of the thresholds of taste sensitivity to table salt in a population study].

The study of an organized population has revealed three types of gustatory sensitivity to sodium chloride: low, medium and high. A certain dependence of salt sensitivity threshold on sex and age has been found. The examination of hypertensive patients in hospitals has revealed that patients with low gustatory sensitivity to salt are characterized by sodium and water retention.

[Standardization in the study of water-containing spaces in patients with hypertension].

The study of hypertensive and normotensive patients has shown that as body weight increases the size of water-containing spaces decreases due to an improportional increase of the body surface area. The rise of total water content occurs mostly due to intracellular fluid. Patients with different sodium chloride consumption are characterized by different redistribution of extracellular fluid.

[Partial purification and properties of cGMP-dependent protein kinase from prawn tissue].

Using ion-exchange chromatography and gel filtration, cGMP-dependent protein kinase was purified from prawn tissues 220-fold with a yield of activity of 12%. The apparent Ka values for cGMP, cAMP and 8-Br-cGMP are 1 . 10(-7), 5 .