Publications by authors named "Musa Ibrahim"

Quality of life (QoL) may change in female patients with breast cancer over time due to its dynamic construct. Recent studies have provided statistics on the diverse predictors of QoL in breast cancer patients. Still, the literature findings on the prognostication of QoL are scarce.

View Article and Find Full Text PDF

Multiple myeloma is a hematological cancer caused by the uncontrolled proliferation of abnormal plasma cells in the bone marrow, leading to excessive immunoglobulin production. Our study aimed to examine the anticancer properties of BRF1A, a cannabinoid (CBD)-enriched product, on 2 myeloma cell lines: U266 and ARH-7. We treated U266 and ARH-77 myeloma cells with varying doses of BRF1A and measured the production of IgE and IgG antibodies using ELISA.

View Article and Find Full Text PDF
Article Synopsis
  • Food allergies affect nearly 30 million people in the U.S., and managing them primarily involves avoiding allergens due to limited treatment options; this study explores the small molecule compound formononetin as a potential therapeutic alternative.* -
  • The study findings reveal that formononetin significantly reduces IgE production and prevents mast cell degranulation in laboratory tests, indicating its potential effectiveness in treating food allergies.* -
  • Formononetin impacts multiple targets related to food allergies and other diseases, and pathway analyses suggest it might influence processes involving B cell proliferation, primary immunodeficiency, and cancer pathways.*
View Article and Find Full Text PDF

This study assessed the manual handling of materials in a local market environment and evaluated workers' awareness of ergonomics and health risks. Of 315 workers surveyed, 308 responded. The findings revealed a high prevalence rate of 96.

View Article and Find Full Text PDF

This study evaluated the perception of patent and proprietary medicine vendors (PPMVs) of the accreditation programme to improve their capacity to provide family planning (FP) services in Lagos and Kaduna, Nigeria. A cross-sectional mixed-method approach among 224 PPMVs was used to investigate their perception, willingness to pay for and adhere to the programme, its benefits, and the community women's perception of the value of PPMVs. Chi-square analysis and structural equation modelling (SEM) were used to analyse survey data, while focus group discussions (FGDs) were analysed using the grounded theory.

View Article and Find Full Text PDF

Prostate cancer is a leading cause of morbidity and mortality among men globally. In this study, we employed an in silico approach to predict the possible mechanisms of action of selected novel compounds reported against prostate cancer epigenetic targets and their derivatives, exhausting through ADMET profiling, drug-likeness, and molecular docking analyses. The selected compounds: sulforaphane, silibinin, 3, 3'-diindolylmethane (DIM), and genistein largely conformed to ADMET and drug-likeness rules including Lipinski's.

View Article and Find Full Text PDF

Introduction: Food allergy is a significant public health problem with limited treatment options. As Food Allergy Herbal Formula 2 (FAHF-2) showed potential as a food allergy treatment, we further developed a purified version named EBF-2 and identified active compounds. We investigated the mechanisms of EBF-2 on IgE-mediated peanut (PN) allergy and its active compound, berberine, on IgE production.

View Article and Find Full Text PDF

Rationale: IgE plays an important pathologic role in most, if not all, allergic conditions. We previously showed that ASHMI (anti-asthma herbal medicine intervention) suppressed IgE production in murine models of asthma and in asthma subjects. However, the active compounds in ASHMI responsible for the IgE suppression are still unknown.

View Article and Find Full Text PDF
Article Synopsis
  • Cytochrome P450 (CYP) 3A4 is crucial for metabolizing corticosteroids, and the study investigates how the herbal remedy epimedium affects this enzyme and its interaction with corticosteroids.
  • Epimedium was found to inhibit CYP3A4 activity in a dose-dependent manner and reduced CYP3A4 mRNA expression, while dexamethasone increased its expression but was suppressed by epimedium.
  • The active compound kaempferol from epimedium showed significant inhibition of pro-inflammatory cytokines, IL-8 and TNF-α, enhancing anti-inflammatory effects while also inhibiting CYP3A4 activity.
View Article and Find Full Text PDF

This study presents optimization and prediction of tribological behaviour of filled polytetrafluoroethylene (PTFE) composites using hybrid Taguchi and support vector regression (SVR) models. To achieve the optimization, Taguchi Deng was employed considering multiple responses and process parameters relevant to the tribological behaviour. Coefficient of friction (µ) and specific wear rate (K) were measured using pin-on-disc tribometer.

View Article and Find Full Text PDF

Atrogin-1 and Muscle-specific RING finger protein 1 (MuRF1) are highly expressed in multiple conditions of skeletal muscle atrophy. The phosphoinositide 3-kinase (PI3K)/Akt/forkhead box (FoxO) signaling pathway is well known to regulate Atrogin-1 and MuRF1 gene expressions. However, Akt activation also activates the mechanistic target of rapamycin complex 1 (mTORC1), which induces skeletal muscle hypertrophy.

View Article and Find Full Text PDF

Introduction: Cancer is a major public health problem and a global leading cause of death where the screening, diagnosis, prediction, survival estimation, and treatment of cancer and control measures are still a major challenge. The rise of Artificial Intelligence (AI) and Machine Learning (ML) techniques and their applications in various fields have brought immense value in providing insights into advancement in support of cancer control.

Methods: A systematic and thematic analysis was performed on the Scopus database to identify the top 100 cited articles in cancer research.

View Article and Find Full Text PDF
Article Synopsis
  • * Ten different risk prediction models were developed using logistic regression and evaluated for accuracy and reliability, ultimately selecting one model that demonstrated strong predictive capabilities with an Area Under the Receiver Operating Characteristic Curve (AUROC) of 0.91.
  • * Findings indicated a high prevalence of MetS in the cohort (19.6%), with notable differences between genders in various health metrics, underscoring the importance of effective risk assessment tools for MetS in midlife populations.
View Article and Find Full Text PDF

Purpose: To assess whether there is a long-term relationship between childhood behaviour problems and type 2 diabetes in midlife. The study will also investigate whether any of such relationship is independent of other factors which may be associated with type 2 diabetes.

Design: Cohort study.

View Article and Find Full Text PDF

This study explores the potential effects of alien fishes on the native fish community, well-being, and tropic preferences in selected rivers of Klang Valley, Malaysia. Following the Aquatic Species Invasiveness Screening Kit assessment, most of the alien fishes (80%) are invasive. The alien species occurrences correlated positively ( < 0.

View Article and Find Full Text PDF

Peste des petits ruminants (PPR) is a highly contagious viral disease that mainly affects goats and sheep in Asia, Africa and the Middle East, and threatens Europe [R.E.1].

View Article and Find Full Text PDF
Article Synopsis
  • Skeletal muscle protein turnover is essential for maintaining muscle mass and ensuring protein quality, involving a balance of protein synthesis and degradation, largely regulated by the ubiquitin proteasome system (UPS).
  • Aging and diseases can impair this protein turnover, but exercise can enhance muscle protein synthesis and may also improve understanding of degradation processes, which are less well understood.
  • This review focuses on new insights into the molecular mechanisms regulating protein degradation through phosphorylation and ubiquitylation modifications, as well as advancements in measuring muscle protein degradation rates using stable isotope tracer methods.
View Article and Find Full Text PDF

Background: Mycetoma is a neglected tropical disease that attracts little attention in regard to research and publications and hence this study was undertaken to determine the trends and global scientific research output in mycetoma-related fields.

Methods: Mycetoma data were retrieved from the Web of Science (WoS) and Scopus databases. The MeSH Browser was used to extract relevant keywords.

View Article and Find Full Text PDF

Compound 3,4-dichloroaniline (3,4-DCA) is a metabolite of several urea herbicides and intermediate chemical of several industrial products. Moreover, 3,4-DCA has been frequently detected in aquatic ecosystems around the world. This aniline is more toxic than the parent chemicals, and it affects non-target organisms.

View Article and Find Full Text PDF
Article Synopsis
  • * The World Health Organization calls for urgent assessments of microplastics' environmental pollution and health impacts, highlighting a gap in research on their toxic effects and absence of regulatory policies for food safety.
  • * Current regulations on plastics are limited to a few countries and often poorly implemented, prompting a need for more animal studies to better understand microplastic toxicity and influence effective policies for public health protection.
View Article and Find Full Text PDF
Article Synopsis
  • Grafting is an essential practice in sustainable vegetable farming, significantly aiding in managing soil-borne diseases and improving crop growth and yields.
  • The study tested different grafting techniques on high-yielding eggplant varieties combined with wild rootstocks to evaluate their growth and yield traits, noting high germination rates and successful grafts.
  • Results showed that using specific wild rootstocks, particularly MWR and TWR, led to increased fruit yield, size, and overall vigor compared to non-grafted and self-grafted versions, highlighting grafting's effectiveness for eggplant production.
View Article and Find Full Text PDF

The most vital aspect of marker-assisted backcross breeding is the recurrent parent genome recovery. This enables the selection of only parents with recovered recipient/recurrent parent genome in addition to the targeted genes. The recurrent parent genome recovery (RPGR) ensures that non-desirable genomic segments are removed while the gene of interest is sustained in the recombined progenies without further segregations.

View Article and Find Full Text PDF

To date, SARS-CoV-2 (the virus that causes COVID-19) has spread to almost every region of the world, infecting millions and resulting in the deaths of hundreds of thousands of people. Although it was predicted that Africa would suffer a massive loss of life due to this pandemic, the number of COVID-19 cases has been relatively low across the continent. Researchers have speculated that several factors may be responsible for this outcome in Africa, including the extensive experience that countries have with infectious diseases and the young median age of their populations.

View Article and Find Full Text PDF

Early-life exposure to toxic chemicals causes irreversible morphological and physiological abnormalities that may last for a lifetime. The present study aimed to determine the toxicity effect of 3,4-Dichloroaniline (3,4-DCA) on Javanese medaka () embryos. Healthy embryos were exposed to various 3,4-DCA concentrations for acute toxicity (5, 10, 25, 50, and 100 mg.

View Article and Find Full Text PDF