Phytochemical investigation of the aqueous methanol and butanol extracts of from Jordan resulted in the isolation of 17 compounds including one new abietane diterpene derivative that was identified as 2,20-dihydroxyferruginol. Structural elucidation of all isolated compounds was based on extensive analysis of their spectroscopic data.[Formula: see text].
View Article and Find Full Text PDFThe new cyclic polyketide 7,9,11-trihydroxytetracos-2-eneoic acid -lactone (), together with other eleven known compounds, were isolated from , growing wildly in Jordan. All isolated compounds were identified by thorough investigation of their spectral data including NMR and HRESIMS. Antioxidant activity testing of puerol B, specionin and the new cyclic polyketide revealed that puerol B had the highest DPPH radical scavenging activity (IC 0.
View Article and Find Full Text PDFThe volatile principles emitted from different aerial organs of two S. palaestina Benth. populations (Mediterranean (Med) and Irano-Turanian (IrT)) growing wild in Jordan were extracted by Solid Phase Micro-Extraction (SPME) and analysed by GC/MS technique.
View Article and Find Full Text PDFEthnopharmacological Relevance: Pituranthos scoparius is a medicinal plant belonging to the Apiaceae family. It thrives in North Africa, and is widely distributed in the high plateau of most parts of the Sahara in Algeria. This plant is widely used in the Algerian traditional medicine to treat numerous infectious diseases, dermatoses, nervous breakdowns, digestive disorders, and calm abdominal pain.
View Article and Find Full Text PDFThe current investigation reports the chemical composition of volatile organic compounds emitted from the different aerial organs of two populations of Salvia dominica L. from Jordan collected from Mediterranean and Irano-Turanian bio-geographical zones. Oxygenated monoterpenes dominated the emission profiles of most organs from the two populations but with variable qualitative and quantitative differences.
View Article and Find Full Text PDFThe aroma emitted from the different organs of two Salvia verbenaca L. populations from Jordan were extracted by Solid Phase Micro-Extraction (SPME) and then analyzed by GC/MS. The emission profile of the stem, leaf and sepal samples from the Mediterranean zone (Al-Salt) was dominated by monoterpene hydrocarbons (68.
View Article and Find Full Text PDFInvestigation of the chemical constituents of growing wild in Jordan led to the isolation and identification of 15 known compounds. These included: luteolin-3'-methyl ether (), indole-3-carboxyaldehyde (), -hydroxybenzaldehyde (), tricin (), apigenin (), methyl isoferuloyl-7-(3,4-dihydroxyphenyl) lactate (), methyl rosmarinate (, rosmarinic acid (), salvigenin (), -sitosterol (), 3, 28-dihydroxyurs-12-ene (), cirsilineol (), 2,3-dihydroxyurs-12-en-28-oic acid (), -sitosteryl glucoside (), and tormentic acid (). Compounds and exhibited strong radical scavenging and chelating activities as compared to α-tocopherol and ascorbic acid, compound showed a 2-fold greater antioxidant activity as compared to compound .
View Article and Find Full Text PDFTwenty-two alkaloids, were isolated from . Two of these alkaloids, N-methyl-5-hydroxystylopine chloride and fumaricine N-oxide, were isolated for the first time from natural sources. Parfumine and fumaritine, in concentrations ranging from 3 × 10 to 9 × 10M, caused concentration-dependent relaxation of ileum longitudinal segment.
View Article and Find Full Text PDFPhytochemical investigation of the chemical constituents of the aerial parts of Scabiosa prolifera L. led to the isolation of one new flavonol glycoside, kaempferol-3-O-(4″,6″-di-E-p-coumaroyl)-β-D-galactopyranoside (1), along with ten other known compounds including luteolin-7-O-(2″-O-ethyl-β-glucopyranoside), β-sitosterol, β-sitosterylglucoside, ursolic acid, corosolic acid, ursolic acid 3-O-β-D-arabinopyranoside, apigenin, methyl-α-D-glucopyranoside, luteolin-7-O-β-glucopyranoside and isoorientin. The structures of all isolated compounds were established using chemical methods and spectroscopic methods including IR, UV, NMR (1D and 2D) and HRESIMS.
View Article and Find Full Text PDFInvestigation of the chemical constituents of Aristolochia maurorum growing wild in Jordan resulted in the isolation and characterisation of one new compound in addition to 19 known compounds. The new compound was identified as aristolochic acid II alanine amide (14). The other known compounds were the following: palmitic acid (1), β-sitosterol (2), E-ethyl-p-coumarate (3), Z-ethyl-p-coumarate (4), aristolochic acid IV methyl ester (5), aristolactam I (6), loliolide (7), (+)-dehydrovomifoliol (8), glycerol-1-palmitate (9), aristolochic acid I (10), E-p-coumaric acid (11), E-N-coumaroyltyramine (12), β-sitosteryl glucoside (13), aristolochic acid IV (15), aristolochic acid III (16), esculetin (17), uracil (18), shepherdine (19) and adenosine (20).
View Article and Find Full Text PDFBackground: The emergence of drug-resistant bacteria in clinical practice has propelled a concerted effort to find new classes of antibiotics that will circumvent current modes of resistance. We previously described a set of imidazopyridine antibacterial leads that contain a core composed of benzimidazole and a central phthalic acid linker. These compounds showed potent antibacterial properties against a wide range of Gram-positive and Gram-negative bacteria.
View Article and Find Full Text PDFChemical investigation of Gynandriris sisyrinchium (L.) Parl growing in Jordan resulted in the isolation and characterization of a total of twelve compounds two of which are reported here for the first time in nature. These new compounds included the isoflavones; 3'-methyl tenuifone (2) and gynandrinone (5).
View Article and Find Full Text PDFTwo new cardenolides, named ischarin and ischaridin in addition to 10 known compounds, were isolated from Calotropis procera Ait. (Asclepiadaceae), growing wild in Jordan. Their structures were established mainly by the extensive application of one- and two-dimensional (1)H and (13)C-NMR spectroscopy.
View Article and Find Full Text PDFIn this investigation, the screening of two furanocoumarins; 5,8- dimethoxypsoralen (1) and heraclinin (2), isolated from the methanol root-extracts of Tamus communis L for their antioxidant activity and xanthine oxidase inhibitory effect was carried out, using different assays such as DPPH free radical scavenging effect, β- carotene / linoleic acid, xanthine oxidase (XO) inhibition and in addition to blood total antioxidant capacity. Results revealed that the two compounds have significant DPPH radical scavenging activity and effective inhibition of linoleic acid oxidation in a dose-dependent manner; 5,8-dimethoxypsoralen exhibited the highest activity with an I% = 72.69 ± 1.
View Article and Find Full Text PDFThree new seco-ursadiene triterpenoids 1-3 together with 11 known compounds were isolated from Salvia syriaca of Jordanian origin. The compounds were identified by using NMR spectroscopy including extensive 2D NMR experiments and mass spectrometry. The structure of compound 3 was confirmed by X-ray crystallography, and the information thus obtained was used to confirm the stereochemistry of compounds 1 and 2.
View Article and Find Full Text PDFInula graveolens is a poisonous annual plant of Mediterranean origin. The invasive nature of the plant suggests that it may possess phytotoxic activity. The aim of this study was to assess the ability of I.
View Article and Find Full Text PDFInvestigation of the butanol fraction of Salvia palaestina Benth. from Jordanian origin resulted in the isolation and characterization of nine compounds, three of which are reported here for the first time in Nature. These compounds included the two phenolics: salpalaestinin (1), methyl 3-O-methylrosmarinate (3) and the flavonoid luteolin 7-O-(2″-p-hydroxybenzoyl)-β-glucuronide) (8).
View Article and Find Full Text PDFActa Crystallogr Sect E Struct Rep Online
October 2012
In the title compound, C(17)H(13)NO(2), the dihedral angle between the plane of the carb-oxy group and the quinoline mean plane is 45.05 (13)°, and that between the toluene ring mean plane and the quinoline mean plane is 25.29 (7)°.
View Article and Find Full Text PDFTwo new triterpenes of the taraxasterol skeleton are isolated for the first time form Pergularia tomentosa L. of Algerian origin. The new compounds were named pergularine A and pergularine B.
View Article and Find Full Text PDFThe novel seco-ursane-type triterpenoid 3β,11α-dihydroxy-17,22-seco-17(28), 12-ursadien-22-oic acid (1) was isolated for the first time from a natural source from two Salvia species growing wild in Jordan, Salvia palaestina Benth. and Salvia syrica L. In addition to compound 1, S.
View Article and Find Full Text PDFThe antiproliferative and antimicrobial effects of thirteen compounds isolated from Inula viscosa (L.) were tested in this study. The antiproliferative activity was tested against three cell lines using the MTT assay.
View Article and Find Full Text PDFSeventeen compounds, including a new lanostane triterpenoid, 24(Z)-1β-3β-dihydroxyeupha-7,24-dien-26-oic acid, have been isolated from the methanolic extracts of two samples of Jordanian propolis collected from two different places with different dominant flora. The structures of the isolated compounds were elucidated by spectral methods including IR, UV, MS and 1- and 2-D NMR.
View Article and Find Full Text PDFJ Asian Nat Prod Res
September 2010
Phytochemical investigation of Osyris alba L. (Santalaceae) of Jordanian origin resulted in the isolation and identification of one new pyrrolizidine alkaloid, osyrisine (1), together with 16 other known compounds. The structures of all compounds were established on the basis of spectroscopic analysis.
View Article and Find Full Text PDFInvestigation of the aerial parts of Sisymbrium irio L. (Cruciferea) collected in northern Jordan afforded two new compounds, sitosteryl-6'-O-undecanoate-beta-D-glucoside (1) and (Z)-8,11,12-trihydroxyoctadec-9-enoic acid (2), in addition to 12 known compounds, 10 of which are reported for the first time from the plant. The structures of all of the compounds were established by spectroscopic and chemical methods.
View Article and Find Full Text PDFInvestigation of Inula viscosa of Jordanian origin afforded the new sesquiterpene 1beta-hydroxyilicic acid in addition to the known 2beta-hydroxyilicic acid.
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