Two new compounds from growing wildly in Jordan.

Phytochemical investigation of the aerial parts and latex of from Jordan, utilizing column chromatography accompanied with NMR (1 & 2D), IR, UV, and HR-ESI-Mass spectroscopy have led to the isolation and characterization of two new compounds, pergularol and 3-O-acetyl-28-hydroxytaraxasterol for the first time along with other ten known compounds including linoleic acid , 3'-didehydroafroside , apigenin , β-sitosteryl glucoside , luteolin , apigenin 7-(6''-crotonoyl)glucoside , 3'-O-β-glucopyranosylcalotropin , apigenin-7-O-β-D-glycoside , pergularine A , taraxasterol . Compound is isolated for the first time from genus.

A new diterpene and other constituents of from Jordan.

Phytochemical investigation of the aqueous methanol and butanol extracts of from Jordan resulted in the isolation of 17 compounds including one new abietane diterpene derivative that was identified as 2,20-dihydroxyferruginol. Structural elucidation of all isolated compounds was based on extensive analysis of their spectroscopic data.[Formula: see text].

A new cyclic polyketide and other constituents from growing wildly in Jordan and their antioxidant activity.

The new cyclic polyketide 7,9,11-trihydroxytetracos-2-eneoic acid -lactone (), together with other eleven known compounds, were isolated from , growing wildly in Jordan. All isolated compounds were identified by thorough investigation of their spectral data including NMR and HRESIMS. Antioxidant activity testing of puerol B, specionin and the new cyclic polyketide revealed that puerol B had the highest DPPH radical scavenging activity (IC 0.

Aroma Profiles Analysis of Two Populations of Salvia palaestina Benth. Collected from Mediterranean and Irano-Turanian Zones in Jordan.

The volatile principles emitted from different aerial organs of two S. palaestina Benth. populations (Mediterranean (Med) and Irano-Turanian (IrT)) growing wild in Jordan were extracted by Solid Phase Micro-Extraction (SPME) and analysed by GC/MS technique.

Ethnomedicinal documentation and anti-inflammatory effects of n-butanol extract and of four compounds isolated from the stems of Pituranthos scoparius: An in vitro and in vivo investigation.

Ethnopharmacological Relevance: Pituranthos scoparius is a medicinal plant belonging to the Apiaceae family. It thrives in North Africa, and is widely distributed in the high plateau of most parts of the Sahara in Algeria. This plant is widely used in the Algerian traditional medicine to treat numerous infectious diseases, dermatoses, nervous breakdowns, digestive disorders, and calm abdominal pain.

Characterization of Chemical Components in Organs Emissions of Two Salvia dominica L. Populations from Jordan.

The current investigation reports the chemical composition of volatile organic compounds emitted from the different aerial organs of two populations of Salvia dominica L. from Jordan collected from Mediterranean and Irano-Turanian bio-geographical zones. Oxygenated monoterpenes dominated the emission profiles of most organs from the two populations but with variable qualitative and quantitative differences.

Aroma Profile of Two Populations of Salvia verbenaca Collected from Two Bio-Geographical Zones from Jordan.

The aroma emitted from the different organs of two Salvia verbenaca L. populations from Jordan were extracted by Solid Phase Micro-Extraction (SPME) and then analyzed by GC/MS. The emission profile of the stem, leaf and sepal samples from the Mediterranean zone (Al-Salt) was dominated by monoterpene hydrocarbons (68.

Chemical constituents of the aerial parts of Boiss. from Jordan.

Investigation of the chemical constituents of growing wild in Jordan led to the isolation and identification of 15 known compounds. These included: luteolin-3'-methyl ether (), indole-3-carboxyaldehyde (), -hydroxybenzaldehyde (), tricin (), apigenin (), methyl isoferuloyl-7-(3,4-dihydroxyphenyl) lactate (), methyl rosmarinate (, rosmarinic acid (), salvigenin (), -sitosterol (), 3, 28-dihydroxyurs-12-ene (), cirsilineol (), 2,3-dihydroxyurs-12-en-28-oic acid (), -sitosteryl glucoside (), and tormentic acid (). Compounds and exhibited strong radical scavenging and chelating activities as compared to α-tocopherol and ascorbic acid, compound showed a 2-fold greater antioxidant activity as compared to compound .

Chemical constituents of and the effects of some isolated spirobenzylisoquinoline alkaloids on murine isolated ileum and perfused heart.

Twenty-two alkaloids, were isolated from . Two of these alkaloids, N-methyl-5-hydroxystylopine chloride and fumaricine N-oxide, were isolated for the first time from natural sources. Parfumine and fumaritine, in concentrations ranging from 3 × 10 to 9 × 10M, caused concentration-dependent relaxation of ileum longitudinal segment.

Fungal biotransformation of diuretic and antihypertensive drug spironolactone with Gibberella fujikuroi, Curvularia lunata, Fusarium lini, and Aspergillus alliaceus.

Derivatives of spironolactone (1), a diuretic and antihypertensive drug, were synthesized by using fungal cells for the first time. Ten different fungi were screened for their ability to biotransform 1, four of which were able to produce metabolites 2-8. Gibberella fujikuroi produced canrenone (2), 1-dehydrocanrenone (3), Curvularia lunuta provided compound 2, and 7α-thio-spironolactone (4), Fusarium lini yielded compounds 2, 3, 1β-hydroxycanrenone (5), 1α-hydroxycanrenone (6), 1-dehydro-15α-hydroxycanrenone (7), and 15α-hydroxycanrenone (8), while Aspergillus alliaceus was able to produce all the seven metabolites.

New flavonol glycoside from Scabiosa prolifera L. aerial parts with in vitro antioxidant and cytotoxic activities.

Phytochemical investigation of the chemical constituents of the aerial parts of Scabiosa prolifera L. led to the isolation of one new flavonol glycoside, kaempferol-3-O-(4″,6″-di-E-p-coumaroyl)-β-D-galactopyranoside (1), along with ten other known compounds including luteolin-7-O-(2″-O-ethyl-β-glucopyranoside), β-sitosterol, β-sitosterylglucoside, ursolic acid, corosolic acid, ursolic acid 3-O-β-D-arabinopyranoside, apigenin, methyl-α-D-glucopyranoside, luteolin-7-O-β-glucopyranoside and isoorientin. The structures of all isolated compounds were established using chemical methods and spectroscopic methods including IR, UV, NMR (1D and 2D) and HRESIMS.

New aristolochic acid and other chemical constituents of Aristolochia maurorum growing wild in Jordan.

Investigation of the chemical constituents of Aristolochia maurorum growing wild in Jordan resulted in the isolation and characterisation of one new compound in addition to 19 known compounds. The new compound was identified as aristolochic acid II alanine amide (14). The other known compounds were the following: palmitic acid (1), β-sitosterol (2), E-ethyl-p-coumarate (3), Z-ethyl-p-coumarate (4), aristolochic acid IV methyl ester (5), aristolactam I (6), loliolide (7), (+)-dehydrovomifoliol (8), glycerol-1-palmitate (9), aristolochic acid I (10), E-p-coumaric acid (11), E-N-coumaroyltyramine (12), β-sitosteryl glucoside (13), aristolochic acid IV (15), aristolochic acid III (16), esculetin (17), uracil (18), shepherdine (19) and adenosine (20).

Design, Synthesis and Qualitative Structure Activity Relationship Evaluations of Quinoline-Based Bisarylimidazoles as Antibacterial Motifs.

Background: The emergence of drug-resistant bacteria in clinical practice has propelled a concerted effort to find new classes of antibiotics that will circumvent current modes of resistance. We previously described a set of imidazopyridine antibacterial leads that contain a core composed of benzimidazole and a central phthalic acid linker. These compounds showed potent antibacterial properties against a wide range of Gram-positive and Gram-negative bacteria.

New isoflavones from Gynandriris sisyrinchium and their antioxidant and cytotoxic activities.

Chemical investigation of Gynandriris sisyrinchium (L.) Parl growing in Jordan resulted in the isolation and characterization of a total of twelve compounds two of which are reported here for the first time in nature. These new compounds included the isoflavones; 3'-methyl tenuifone (2) and gynandrinone (5).

Two novel cardenolides from Calotropis procera.

Two new cardenolides, named ischarin and ischaridin in addition to 10 known compounds, were isolated from Calotropis procera Ait. (Asclepiadaceae), growing wild in Jordan. Their structures were established mainly by the extensive application of one- and two-dimensional (1)H and (13)C-NMR spectroscopy.

Antioxidant Potentials and Xanthine Oxidase Inhibitory Effect of Two Furanocoumarins Isolated from Tamus communis L.

In this investigation, the screening of two furanocoumarins; 5,8- dimethoxypsoralen (1) and heraclinin (2), isolated from the methanol root-extracts of Tamus communis L for their antioxidant activity and xanthine oxidase inhibitory effect was carried out, using different assays such as DPPH free radical scavenging effect, β- carotene / linoleic acid, xanthine oxidase (XO) inhibition and in addition to blood total antioxidant capacity. Results revealed that the two compounds have significant DPPH radical scavenging activity and effective inhibition of linoleic acid oxidation in a dose-dependent manner; 5,8-dimethoxypsoralen exhibited the highest activity with an I% = 72.69 ± 1.

Three new seco-ursadiene triterpenoids from Salvia syriaca.

Three new seco-ursadiene triterpenoids 1-3 together with 11 known compounds were isolated from Salvia syriaca of Jordanian origin. The compounds were identified by using NMR spectroscopy including extensive 2D NMR experiments and mass spectrometry. The structure of compound 3 was confirmed by X-ray crystallography, and the information thus obtained was used to confirm the stereochemistry of compounds 1 and 2.

Selective phytotoxic activity of 2,3,11β,13-tetrahydroaromaticin and ilicic acid isolated from Inula graveolens.

Inula graveolens is a poisonous annual plant of Mediterranean origin. The invasive nature of the plant suggests that it may possess phytotoxic activity. The aim of this study was to assess the ability of I.

Flavonoid and phenolic compounds from Salvia palaestina L. growing wild in Jordan and their antioxidant activities.

Investigation of the butanol fraction of Salvia palaestina Benth. from Jordanian origin resulted in the isolation and characterization of nine compounds, three of which are reported here for the first time in Nature. These compounds included the two phenolics: salpalaestinin (1), methyl 3-O-methylrosmarinate (3) and the flavonoid luteolin 7-O-(2″-p-hydroxybenzoyl)-β-glucuronide) (8).

Two new taraxasterol-type triterpenes from Pergularia tomentosa growing wild in Algeria.

Two new triterpenes of the taraxasterol skeleton are isolated for the first time form Pergularia tomentosa L. of Algerian origin. The new compounds were named pergularine A and pergularine B.

New terpenes from Salvia palaestina Benth. and Salvia syriaca L. growing wild in Jordan.

The novel seco-ursane-type triterpenoid 3β,11α-dihydroxy-17,22-seco-17(28), 12-ursadien-22-oic acid (1) was isolated for the first time from a natural source from two Salvia species growing wild in Jordan, Salvia palaestina Benth. and Salvia syrica L. In addition to compound 1, S.

Chemical constituents of Osyris alba and their antiparasitic activities.

Phytochemical investigation of Osyris alba L. (Santalaceae) of Jordanian origin resulted in the isolation and identification of one new pyrrolizidine alkaloid, osyrisine (1), together with 16 other known compounds. The structures of all compounds were established on the basis of spectroscopic analysis.

New withanolides from Mandragora officinarum: first report of withanolides from the Genus Mandragora.

Two new withanolides named mandragorolide A (1) and mandragorolide B (2) were isolated from the MeOH extract of the whole plant of Mandragora officinarum of Jordanian origin, along with five known withanolides namely larnaxolide A (3), withanolide B (4), datura lactone 2 (5), withanicandrin (6) and salpichrolide C (7). Compound 3 has been reported only once before, from the leaves of Larnax glabra. This is the first report of withanolides of different biogenetic types from the genus Mandragora.

Chemical constituents of Sisymbrium irio L. from Jordan.

Investigation of the aerial parts of Sisymbrium irio L. (Cruciferea) collected in northern Jordan afforded two new compounds, sitosteryl-6'-O-undecanoate-beta-D-glucoside (1) and (Z)-8,11,12-trihydroxyoctadec-9-enoic acid (2), in addition to 12 known compounds, 10 of which are reported for the first time from the plant. The structures of all of the compounds were established by spectroscopic and chemical methods.

A arylnaphthalene lignan from Haplophyllum buxbaumii.

Haplophyllum buxbaumii has yielded a new diphyllin glycoside, which was characterized as 4-O-{bis-alpha-L-xylopyranosyl (1-->2, 1-->5) beta-D-apiofuranosyloxy}-6,7-dimethoxy-1-(3,4-methylenedioxyphenyl)-3-hydroxymethyl naphthalene-2-carboxylic acid lactone. Taiwanin-H is also reported for the first time from a member of the Rutaceae.