Yoga and Cardiovascular Diseases - A Mechanistic Review.

Yoga is an ancient Indian practice that involves the mind and body. It is a combination of physical exercises and postures with a focus on deep breathing and meditation. Yoga thereby promotes a healthy lifestyle which is one of the key factors in the prevention of various cardiovascular diseases.

Assessing the Ecological Quality Status in tropical Indian estuaries: testing the applicability of benthic foraminiferal indices.

The ecological quality status (EcoQS) of Vellar and Uppanar estuaries (Southeast coast of India) has been monitored monthly, using a combination of foraminiferal (Foram Stress Index: FSI and exp(H') indices and abiotic (Pollution Load Index: PLI, Dissolved Oxygen: DO, and Total Organic Carbon: TOC) parameters. The Uppanar Estuary shows relatively higher values of PLI and TOC and lower DO values than Vellar Estuary. The highest value of TOC and PLI are recorded during the monsoon season.

Assessment of ecological status of Uppanar and Vellar estuaries through multivariate pollution indices.

Multivariate pollution degree indices were utilized to evaluate the environmental condition of the Uppanar and Vellar estuaries. The Trophic Index (TRIX) indicates a state of "moderate eutrophication" with a value of 4.92, while the Trophic State Index (TSI) ranged from 40.

Improving treatment adherence among tuberculosis patients through evening DOTS in Chennai, India.

Background Fixed days and timings of service are challenges in the care of patients with tuberculosis (TB). We assessed whether provision of evening DOTS (directly observed treatment, short course) improves treatment outcomes in a city with a working population. Methods We enrolled new adult patients with TB from seven tuberculous units (TUs) in this prospective cohort study.

On-demand release of a selective MMP-13 blocker from an enzyme-responsive injectable hydrogel protects cartilage from degenerative progression in osteoarthritis.

In osteoarthritis (OA), the degradation of cartilage is primarily driven by matrix metalloprotease-13 (MMP-13). Hence, the inhibition of MMP-13 has emerged as an attractive target for OA treatment. Among the various approaches that are being explored for MMP-13 regulation, blocking of the enzyme with specific binding molecules appears to be a more promising strategy for preventing cartilage degeneration.

Reversal of Pulmonary Hypertension in a Human-Like Model: Therapeutic Targeting of Endothelial DHFR.

Background: Pulmonary hypertension (PH) is a progressive disorder characterized by remodeling of the pulmonary vasculature and elevated mean pulmonary arterial pressure, resulting in right heart failure.

Methods: Here, we show that direct targeting of the endothelium to uncouple eNOS (endothelial nitric oxide synthase) with DAHP (2,4-diamino 6-hydroxypyrimidine; an inhibitor of GTP cyclohydrolase 1, the rate-limiting synthetic enzyme for the critical eNOS cofactor tetrahydrobiopterin) induces human-like, time-dependent progression of PH phenotypes in mice.

Results: Critical phenotypic features include progressive elevation in mean pulmonary arterial pressure, right ventricular systolic blood pressure, and right ventricle (RV)/left ventricle plus septum (LV+S) weight ratio; extensive vascular remodeling of pulmonary arterioles with increased medial thickness/perivascular collagen deposition and increased expression of PCNA (proliferative cell nuclear antigen) and alpha-actin; markedly increased total and mitochondrial superoxide production, substantially reduced tetrahydrobiopterin and nitric oxide bioavailabilities; and formation of an array of human-like vascular lesions.

Amino Acid-Based Molecular and Membranous Chiral Tools for Enantiomeric Recognition.

Given the need, both academic and industrial, for new approaches and technologies for chiral discrimination of enantiomers, the present work demonstrates the development through rational design and integration of two new chiral platforms (molecular and membranous) for enantioselective recognition through visual as well as microscopic observation. The molecular platform () is based on the tryptophan derivative developed through the condensation of two tryptophan units with terepthaloyl chloride. While based on l-tryptophan recognizes -mandelic acid over the -isomer, the host with reverse chirality () recognizes S-mandelic acid over -isomer.

Reciprocal impulses of junctional origin causing trigeminy.

Reciprocal impulses of junctional origin were seen in a patient with left isomerism who had undergone Kawashima repair in infancy. Heterotaxy syndromes are associated with disturbances in sinus node function. Junctional rhythm is hence common in this group.

Free-flowing, self-crosslinking, carboxymethyl starch and carboxymethyl cellulose microgels, as smart hydrogel dressings for wound repair.

Hydrogels are widely recognized and favoured as moist wound dressings due to their beneficial properties. However, their limited capacity to absorb fluids restricts their use in highly exuding wounds. Microgels are small sized hydrogels that have recently gained considerable attention in drug delivery applications due to their superior swelling behaviour and ease of application.

MXene-Based Nanocomposites for Piezoelectric and Triboelectric Energy Harvesting Applications.

Due to its superior advantages in terms of electronegativity, metallic conductivity, mechanical flexibility, customizable surface chemistry, etc., 2D MXenes for nanogenerators have demonstrated significant progress. In order to push scientific design strategies for the practical application of nanogenerators from the viewpoints of the basic aspect and recent advancements, this systematic review covers the most recent developments of MXenes for nanogenerators in its first section.

Experimental study of bifacial photovoltaic module with waste polyvinyl chloride flex and acrylonitrile butadiene styrene road side safety sticker as an alternative reflector: optimization using response surface methodology.

Bifacial photovoltaics (PV) are gaining rapid attention and their ability to generate more electricity is accelerating their deployment globally. However, literature on optimal bifacial PV is presented for the installation parameters of the system. In this study, we use response surface methodology (RSM) to investigate the flex and roadside reflector wastes as alternate reflectors for bifacial PV modules by using a statistical model.

Experimental Studies on Thermal-Barrier-Coated Engine Fuelled by a Blend of Eucalyptus Oil And DEE.

The present experiment deals with the study of the effect of addition of diethyl ether (DEE) on the performance and emission characteristics of a thermal-barrier-coated (TBC) engine run on papaw (Carica papaya) and eucalyptus oil blends. The fuels studied were test blends, CPME30Eu70 (papaw methyl ester 30% and eucalyptus oil 70%) and CPME30Eu70 + 10% DEE, and diesel. Optimum results were obtained for CPME30Eu70 with DEE in a TBC engine.

Effect of Kariba Weed Biodiesel Blended with -Pentane on the Chosen Parameters of a Ceramic-Coated Thermal Barrier Direct Injection Diesel Engine.

In this experimental investigation, Kariba weed biodiesel (KSB) blended with -pentane has been tested in conventional and ceramic-coated thermal barrier engines, and the results have been compiled and presented. A single-cylinder, four-stroke, direct injection diesel engine has been used as the test engine with eddy current dynamometer loading as used in the experimental setup. The tests were repeated in various ambient conditions to get an optimal value.

Inhibitor of DNA binding/differentiation proteins as IDs for pancreatic cancer: Role in pancreatic cancer initiation, development and prognosis.

A family of inhibitors of cell differentiation or DNA-binding proteins, known as ID proteins (ID1-4), function as mighty transcription factors in various cellular processes, such as inhibiting differentiation, promoting cell-cycle progression, senescence, angiogenesis, tumorigenesis, and metastasis in cancer. Pancreatic cancer represents the deadliest cancer with the lowest survival rate of 10% due to the diagnosis at an advanced fatal stage and therapeutic resistance. Modestly, the only curative option for this lethal cancer is surgery but is done in less than 15-20% of patients because of the locally aggressive and early metastatic nature.

NADPH Oxidase Isoforms in COPD Patients and Acute Cigarette Smoke-Exposed Mice: Induction of Oxidative Stress and Lung Inflammation.

Cigarette smoke (CS) is a major risk factor for chronic obstructive pulmonary disease (COPD), which represents the third leading cause of death worldwide. CS induces reactive oxygen species (ROS) production, leading to pulmonary inflammation and remodeling. NADPH oxidases (NOXs) represent essential sources of ROS production in the cardiovascular system.

Food waste valorisation via gasification - A review on emerging concepts, prospects and challenges.

Disposing of the enormous amounts of food waste (FW) produced worldwide remains a great challenge, promoting worldwide research on the utilization of FW for the generation of value-added products. Gasification is a significant approach for decomposing and converting organic waste materials into biochar, bio-oil, and syngas, which could be adapted for energy (hydrogen (H) and heat) generation and environmental (removal of pollutants and improving the soil quality) applications. Employment of FW matrices for syngas production through gasification is one of the effective methods of energy recovery.

Novel and robust treatment of pulmonary hypertension with netrin-1 and netrin-1-derived small peptides.

Limited medical therapies have been implemented for the treatment of the devastating cardiorespiratory disease of pulmonary hypertension (PH) while none of which is sufficiently effective to stop or regress development of PH. We have previously shown that netrin-1, an axon-guiding protein during development, protects against ischemia reperfusion injury induced myocardial infarction via modest and stable production of nitric oxide (NO) and attenuation of oxidative stress. Since NO deficiency and oxidative stress-mediated vascular remodeling play important roles in the pathogenesis of PH, our present study investigated therapeutic effects on PH of netrin-1 and its derived small peptides.

Western blotting: a powerful staple in scientific and biomedical research.

Western blotting (WB), also known as immunoblotting, is a well-known molecular biology method that biologists often use to investigate many features of the protein, ranging from basic protein analysis to disease detection. WB is simple, unique, rapid, widely used routine tool with easy interpretation and definite results. It is being used in various fields of science, research and development, diagnostic labs and hospitals.

Utilization of zinc-ferrite/water hybrid nanofluids on thermal performance of a flat plate solar collector-a thermal modeling approach.

Thermodynamic performance analysis is carried out on a flat plate solar thermal collector utilizing single and hybrid nanofluids. FeO/water, Zn-FeO/water hybrid nanofluids, and water are used as heat transfer fluids, and their performance is compared based on the energy and exergy transfer rate. The thermo-physical properties are evaluated by regression polynomial model for all the working fluids.

New entoproct-polychaete association recorded in the Bay of Bengal, southeastern coast of India.

The solitary entoproct species, Loxosomella diopatricola is recorded from the Bay of Bengal, southeastern coast of India. The species was found on the eunicid polychaete Diopatra sp. collected from depth of 15 m.

New records for associations between peritrich protozoan ciliates (Ciliophora, Sessilida) and polychaete worms (Annelida) from off the southeastern coast of India.

We report herein three epibiotic associations between peritrich ciliate protozoans and polychaete worms, as observed in Tamilnadu, southeastern coast of India. Epibiont ciliates Epistylis sp.1 were found all over the integument of individuals of the terebellid polychaete Terebella sp.

Autophagic and apoptotic cell death induced by the quinoline derivative 2-(6-methoxynaphthalen-2-yl)quinolin-4-amine in pancreatic cancer cells is via ER stress and inhibition of Akt/mTOR signaling pathway.

Pancreatic cancer (PC) is among the most lethal cancers and is resistant to existing therapies, which highlights the need for new and alternative therapeutic treatments. Autophagy is emerging as one of the alternative cell death mechanisms and is well known to cross-talk with apoptosis. Autophagy can act as a viable option to treat highly resistant PC.