Publications by authors named "Muruganathan Arumugam"

Effective lipid management is crucial for preventing atherosclerotic cardiovascular disease (ASCVD). The Western lipid guidelines may not apply to Indian subjects because of the vast differences in cardiovascular (CV) disease epidemiology. To overcome this challenge, the Lipid Association of India (LAI) in 2016 proposed an ASCVD risk stratification algorithm.

View Article and Find Full Text PDF

Micronutrients play a key role in human health, being involved in energy metabolism, immunity, cellular functioning, growth, and development. Deficiencies in micronutrients occur in individuals of all ages due to several factors, including inadequate diets, disease states, and overweight/obesity. Guidelines from the Indian Council of Medical Research (ICMR) National Institute of Nutrition (NIN) Expert Group on Nutrient Requirements for Indians (2023) have specified the Recommended Dietary Allowances (RDA) for macronutrients and micronutrients.

View Article and Find Full Text PDF

Systemic hypertension is an established risk factor for coronary artery disease and cerebrovascular accident and control of blood pressure reduces the risk of a major cardiovascular event. Both non-pharmacological and pharmacological treatment options are available to treat hypertension. Yoga, recently received more attention as a treatment modality for various lifestyle disorders, even though practiced in India since ancient times.

View Article and Find Full Text PDF

Various scoring systems are available to assess the severity of cirrhosis, that is, the Child-Pugh score and Model for End-Stage Liver Disease (MELD) score. Since the liver is the major site for converting excess carbohydrates into various lipids, the deranged lipid profile can act as a prognostic biomarker of cirrhosis. We assessed the lipid profile abnormalities among patients with cirrhosis of the liver and correlated them with the severity of cirrhosisMaterials and methods: This is an analytical cross-sectional study on lipid profile as an indicator of severity in cirrhosis of the liver among patients admitted to the medical ward of a tertiary care teaching hospital in Tamil Nadu.

View Article and Find Full Text PDF

Lipid-lowering therapy plays a crucial role in reducing adverse cardiovascular (CV) events in patients with established atherosclerotic cardiovascular disease (ASCVD) and familial hypercholesterolemia. Lifestyle interventions along with high-intensity statin therapy are the first-line management strategy followed by ezetimibe. Only about 20-30% of patients who are on maximally tolerated statins reach recommended low-density lipoprotein cholesterol (LDL-C) goals.

View Article and Find Full Text PDF
Article Synopsis
  • The Lipid Association of India recommends specific LDL cholesterol targets for stroke patients, with high-intensity statins as the first-line treatment and the possibility of adding nonstatin therapies if necessary.
  • Continuing statins is crucial for patients with acute ischemic stroke; those who have their statins stopped usually experience worse outcomes, while statins should not be initiated in acute intracerebral hemorrhage cases but continued if already prescribed.
View Article and Find Full Text PDF
Article Synopsis
  • Atherosclerotic cardiovascular disease (ASCVD) rates are rising alarmingly in India, often affecting younger individuals with less severe cholesterol issues compared to Western countries.
  • The Lipid Association of India (LAI) aims to set more aggressive LDL cholesterol goals for secondary prevention and those with familial hypercholesterolemia after extensive expert consultations.
  • The LAI recommends an LDL-C goal of <50 mg/dL for high-risk patients, with even lower targets for specific extreme-risk categories to better manage and reduce ASCVD events in India.
View Article and Find Full Text PDF

Non-alcoholic fatty liver disease (NAFLD) is closely associated with metabolic syndrome. Prevalence of metabolic risk factors including diabetes mellitus, obesity, etc. is rapidly increasing in India putting this population at risk for NAFLD.

View Article and Find Full Text PDF