Publications by authors named "Murthy H"

Electrochromic devices (ECDs) are devices that change their optical properties in response to a low applied voltage. These devices typically consist of an electrochromic layer, a transparent conducting substrate, and an electrolyte. The advancement in solid-state ECDs has been driven by the need for improved durability, optical performance, and energy efficiency.

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In recent decades, poorly insulated windows have increased the energy consumption of heating and cooling systems, thus contributing to excessive carbon dioxide emissions and other related pollution issues. From this perspective, the electrochromic (EC) windows could be a tangible solution as the indoor conditions are highly controllable by these smart devices even at a low applied voltage. Literally, vanadium pentoxide (VO) is a renowned candidate for the EC application due to its multicolor appearance and substantial lithium insertion capacity.

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Patients with newly diagnosed acute myeloid leukemia (ND-AML) derive variable survival benefit from venetoclax + hypomethylating agent (Ven-HMA) therapy. The primary objective in the current study was to develop genetic risk models that are predictive of survival and are applicable at the time of diagnosis and after establishing treatment response. Among 400 ND-AML patients treated with Ven-HMA at the Mayo Clinic, 247 (62%) achieved complete remission with (CR) or without (CRi) count recovery.

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Motivation: Genomic signal processing (GSP), which transforms biomolecular sequences into discrete signals for spectral analysis, has provided valuable insights into DNA sequence, structure, and evolution. However, challenges persist with spectral representations of variable-length sequences for tasks like species classification and in interpreting these spectra to identify discriminative DNA regions.

Results: We introduce SpecGMM, a novel framework that integrates sliding window-based Spectral analysis with a Gaussian Mixture Model to transform variable-length DNA sequences into fixed-dimensional spectral representations for taxonomic classification.

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  • - Phenotypic plasticity in tumor cells allows them to adapt and change due to stressors, playing a key role in tumor progression, as illustrated by a case of a 70-year-old man with pleomorphic adenoma who developed pleomorphic liposarcoma.
  • - Sarcomas, like liposarcoma, can develop from existing pleomorphic adenomas in the parotid gland, with only a few documented cases of primary parotid liposarcoma.
  • - This case report examines the uncharted adenoma-carcinoma-sarcoma progression in pleomorphic adenomas, aiming to provide insights for treatment planning and management from a surgical oncology standpoint.
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Understanding the fundamental frequency and harmonic content of audio signals is crucial for many applications in music analysis, including music transcription, audio synthesis, and genre identification. This study formulates a signal processing approach combining Linear Prediction (LP) analysis and the Cent scale to accurately characterize the pitch and harmonic structure of the audio signals. Pitch tracking on the LP spectrum in the Cent scale provides more accurate and reliable pitch estimation, especially in the presence of noise or overlapping harmonics.

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A highly selective, sensitive caffeic acid (CA) detection based on calcium oxide nanoparticles (CaO NPs) derived from extract of Moringa oleifera leaves decorated graphitic carbon nitride covalently grafted poly vinyl alcohol (CaO/g-CN/PVA) nanocomposite modified glassy carbon electrode (GCE) was studied. A facile sonochemical method was adapted to synthesis nanomaterials and characterized by HR-TEM (High resolution transmission electron microscopy), FT-IR (Fourier transform infrared spectroscopy), XRD (X-ray diffraction), FE-SEM (Field emission scanning electron microscopy), EDX (Energy dispersive X-ray analysis), Mapping and BET (Brunauer-Emmett-Teller) analysis, and electrochemical techniques. The nanocomposite modified GCE exhibited an excellent catalytic performance to the oxidation of CA under optimized conditions owing to better electron transfer efficiency, conductivity and high surface area of the electrode material.

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The study of research proposes a systematic pattern for optimization and fabrication of a sustainable-cost effective electrochemical sensor made by Bi-CdFeO (BCDF) nanoparticle and graphite powder. The structural examinations of synthesized BCDF materials were analyzed by specific spectral techniques viz.; P-XRD, SEM-EDX, TEM, XPS, FT-IR and DRS techniques.

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  • National performance metrics are crucial for improving healthcare delivery and guiding patient decisions, making valid measures necessary.
  • This study analyzed US News and World Report metrics from 2012 to 2019 alongside electronic health record data to evaluate care for patients attributed to the ENT mortality group.
  • The findings revealed that only 23 out of 47 initially attributed ENT deaths were verified, lowering the mortality rate and suggesting a need for better methods in mortality attribution and a shift from specialty rankings to a more comprehensive rating approach.
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is an ancient plant that has survived up until the present day. is a rich source of valuable secondary metabolites, particularly terpene trilactones (TTLs) such as ginkgolides and bilobalides, which are obtained from the leaves and seeds of the plant. TTLs have pharmacological properties, including anticancer, anti-dementia, antidepressant, antidiabetic, anti-inflammatory, anti-hypertensive, antiplatelet, immunomodulatory, and neuroprotective effects.

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is a fruit-bearing tree that is distributed in Southeast Asia and Australia. The objective of this research was to ascertain the following with regard to ripened fruits: (i) their nutritional value, (ii) their mineral status, (iii) the fatty acid composition of fruit and seed oil, (iv) their phytochemical makeup, and (v) their antioxidant properties. The ripened fruits contained 3.

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Doping enhances the optical properties of high-band gap zinc oxide nanoparticles (ZnO NPs), essential for their photocatalytic activity. We used the combustion approach to synthesize cobalt-doped ZnO heterostructure (CDZO). By creating a mid-edge level, it was possible to tune the indirect band gap of the ZnO NPs from 3.

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  • There is a significant challenge with treating relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL) using existing CAR T-cell therapies, particularly as there are no approved options for CLL patients.
  • This study focuses on a new CAR design targeting the B-cell activating factor receptor (BAFF-R), which is crucial for the survival of B-cells and commonly found on CLL tumors.
  • The research showed that BAFF-R CAR T cells are effective in killing CLL cells and can also target resistant CD19-knockout CLL cells, suggesting that this therapy could provide a much-needed treatment option for CLL patients.
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  • - Post-transplant cyclophosphamide (PT-Cy) is becoming the standard treatment to prevent graft-versus-host disease (GVHD) in patients who undergo allogeneic hematopoietic stem cell transplant (alloHCT), but it can cause endothelial damage.
  • - The study investigates whether the endothelial activation and stress index (EASIX) score can predict non-relapse mortality (NRM) in patients receiving PT-Cy, alongside the hematopoietic cell transplantation-specific comorbidity index (HCT-CI) and other survival factors.
  • - Findings from analyzing 199 patients reveal that a high EASIX score significantly correlates with increased NRM (34.5% vs. 12
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In the current world, storing and converting energy without affecting the natural ecosystem are considered a sustainable and efficient green energy source production technology. Especially, using low-cost, environmentally friendly, and high-cycle stability activated carbon (AC) from the water hyacinth () waste material for charge storage application is the current attractive strategy for renewable energy generation. In this study, preparation of AC from water hyacinth using a mixed chemical activation agent followed by activation time was optimized by the I-optimal coordinate exchange design model based on a 3-factor/3-level strategy under nine experimental runs.

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Unirradiated patients with relapsed/refractory (R/R) B-cell non-Hodgkin lymphoma (NHL) who undergo anti-CD19 chimeric antigen receptor T-cell therapy (CART) have a predominant localized pattern of relapse, the significance of which is heightened in individuals with limited/localized disease before CART. This study reports on the outcomes of patients with R/R NHL and limited (<5 involved sites) disease bridged with or without radiotherapy. A multicenter retrospective review of 150 patients with R/R NHL who received CART with <5 disease sites before leukapheresis was performed.

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  • - The study analyzed how different types of donors affect outcomes of hematopoietic cell transplantation (HCT) in patients with myelofibrosis, finding that the use of haploidentical donors rose significantly from 3% in 2013 to 19% in 2019.
  • - Among 1,032 patients with chronic-phase myelofibrosis, matched sibling donor HCTs showed better overall survival in the first three months compared to haploidentical and matched unrelated donor HCTs, with notably lower rates of graft failure.
  • - While matched sibling donors had superior early outcomes, there were no significant differences in long-term survival or disease-free survival among the different donor types, suggesting hap
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  • Angelica Gigas, also known as Purple parsnip, is a valuable medicinal plant found in East Asia, known for its various health benefits due to bioactive compounds, particularly coumarins.
  • The study focused on developing a methodology to regenerate plants from protoplasts, utilizing specific growth regulators to optimize conditions for cell division and callus formation.
  • Successful results were achieved, confirming that protoplast culture and embryogenesis can effectively lead to plant regeneration in Angelica gigas, potentially enhancing its cultivation for medicinal use.
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  • This study introduces eco-friendly methods to produce Zn-doped nickel oxide nanoparticles (Zn:NiO NPs) using aloe vera gel extract and glucose as fuel sources.
  • Characterization techniques like PXRD and electron microscopy reveal that the nanoparticles have a specific crystal structure and unique spongy, spherical, and porous features.
  • The research suggests that Zn:NiO NPs show promising electrical properties, making them a viable and cost-effective material for supercapacitor applications in the future.
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Despite therapeutic advances for acute promyelocytic leukemia (APL) with the emergence of all-trans retinoic acid, arsenic trioxide, and gemtuzumab-ozogamycin, approximately 10% of patients still experience disease relapse, typically occurring within 24 to 36 months following completion of front-line treatment. Traditionally, both allogeneic (allo) and autologous (auto) hematopoietic cell transplantation (HCT) have been considered reasonable treatment options for relapsed APL; however, no randomized controlled studies have been conducted comparing allo-HCT and auto-HCT in patients with relapsed APL. We performed a systematic review/meta-analysis to assess the totality of evidence pertaining to allo-HCT or auto-HCT in relapsed APL.

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