Publications by authors named "Murthy Devarakonda"

Objective: Designing a new clinical trial entails many decisions, such as defining a cohort and setting the study objectives to name a few, and therefore can benefit from recommendations based on exhaustive mining of past clinical trial records. This study proposes an approach based on knowledge graph embeddings and semantics-driven inductive inference for generating such recommendations.

Method: The proposed recommendation methodology is based on neural embeddings trained on first-of-its-kind knowledge graph constructed from clinical trials data.

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Background: Finding specific scientific articles in a large collection is an important natural language processing challenge in the biomedical domain. Systematic reviews and interactive article search are the type of downstream applications that benefit from addressing this problem. The task often involves screening articles for a combination of selection criteria.

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Relation extraction from biomedical text is important for clinical decision support applications. In post-marketing pharmacovigilance, for example, Adverse Drug Events (ADE) relate medical problems to the drugs that caused them and were the focus of two recent shared challenges. While good results were reported, there was a room for improvement.

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Background: The complicated nature of cloud computing encompassing internet-based technologies and service models for delivering IT applications, processing capability, storage, and memory space brings along challenging problems. Some issues such as information security, privacy, and legal aspects of cloud computing may become challenging while cross passing with another complex domain like healthcare.

Objectives: The present study was conducted to report the results of a systematic literature review on the legal aspects of health cloud.

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Background And Significance: Adverse drug events (ADEs) occur in approximately 2-5% of hospitalized patients, often resulting in poor outcomes or even death. Extraction of ADEs from clinical narratives can accelerate and automate pharmacovigilance. Using state-of-the-art deep-learning neural networks to jointly model concept and relation extraction, we achieved the highest integrated task score in the 2018 Medication and Adverse Drug Event (MADE) 1.

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Objective: Abbreviations sense disambiguation is a special case of word sense disambiguation. Machine learning methods based on neural networks showed promising results for word sense disambiguation (Festag and Spreckelsen, 2017) [1] and, here we assess their effectiveness for abbreviation sense disambiguation.

Methods: Convolutional Neural Network (CNN) models were trained, one for each abbreviation, to disambiguate abbreviation senses.

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We present a new model of patient record search, called SemanticFind, which goes beyond traditional textual and medical synonym matches by locating patient data that a clinician would want to see rather than just what they ask for. The new model is implemented by making extensive use of the UMLS semantic network, distributional semantics, and NLP, to match query terms along several dimensions in a patient record with the returned matches organized accordingly. The new approach finds all clinically related concepts without the user having to ask for them.

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Natural language processing (NLP) holds the promise of effectively analyzing patient record data to reduce cognitive load on physicians and clinicians in patient care, clinical research, and hospital operations management. A critical need in developing such methods is the "ground truth" dataset needed for training and testing the algorithms. Beyond localizable, relatively simple tasks, ground truth creation is a significant challenge because medical experts, just as physicians in patient care, have to assimilate vast amounts of data in EHR systems.

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Objective: An accurate, comprehensive and up-to-date problem list can help clinicians provide patient-centered care. Unfortunately, problem lists created and maintained in electronic health records by providers tend to be inaccurate, duplicative and out of date. With advances in machine learning and natural language processing, it is possible to automatically generate a problem list from the data in the EHR and keep it current.

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