DEVELOPMENT OF THE FORMULATION AND TECHNOLOGY OF HYDROGEL, CONTAINING ADJARA REGION SULFIDE SILT PELOID.

In the world today, the demand for the preparations and cosmetics, made of peloids is increasing significantly, which is explained by the increased interest of the community to the ecologically clean raw materials of natural origin, it often replaces expensive chemical preparations, which are often accompanied by some contraindications. The increased interest in peloids in the world put on the agenda the question of rational use of acting mud mines as well as the problem of cosmetic and medicinal preparations, developed on their basis. It is noteworthy that the development of ready-made, soft drug forms from the Adjara region sulfide silt peloids is one of the most topical and important issues, as at present there is not available the form of ready-made drugs containing the sulfide silt peloids of this region.

CHARACTERIZATION OF SULPHIDE SILT PE-LOIDS IN SOME LAKES WITHIN ADJARA REGION AND DETERMINATION OF THE BIOLOGICALLY ACTIVE COMPOUNDS CONTENT.

Medicinal muds, so called Peloids in the last decade attract attention in many countries as effective means for the treatment- preventive, and perfumery-cosmetic purposes. It has been established that the possibilities of this formation of nature are not limited to the many-year experience of the mankind. In terms of further improvement of the human social sphere, nowadays peloids are referred to as XXI century material.

DEVELOPMENT OF THE G C -M S /M S METHOD FOR QUALITATIVE AND QUANTITATIVE DETERMINATION OF CLOZAPINE IN HUMAN BLOOD.

A simple, rapid, selective, sensitive gas chromatography-mass spectrometry (GC-MS/MS) method was developed and validated for the determination of clozapine in human blood. For isolation was used solid phase extraction. The calibration standards range was 5-1500ng/mL.

DEVELOPMENT OF LC-MS/MS METHOD FOR DETERMINATION OF THE OLANZAPINE IN HUMAN PLASMA.

The study aim was to develop a validated selective, reproducible and sensitive Liquid Chromatography - Tandem Mass Spectrometry (LC-MS/MS) method for qualitative and quantitative determination of olanzapin (OLZ ) in human plasma. For isolation was used solid phase extraction with the Gilson GX-271 ASPEC Solid phase extraction system, cartridge Supelclean LC-18 SPE 500mg. Elution solvent contained 40mL of isopropanol, 4mL of concentrated ammonium hydroxide and 156mL of freshly prepared methylene chloride.

Antioxidant polyphenols from Populus alba growing in Georgia.

The aim of the study was to evaluate natural antioxidant properties of Populus alba. The antioxidant effects in plants are mainly due to the presence of phenolic compounds such as flavonoids, phenolic acids, tannins and phenolic diterpenes. Oxidative damage is implicated in most diseases processes.

Biological active compounds from Georgian Galanthus shaoricus.

Amaryllidaceae alkaloids exhibit antitumour, antiviral and anticholinergic activities. Some of them have been used in the treatment of myasthenia gravis, myopathy and diseases of the nervous system. In this study, the characterization of these compounds from Amaryllidaceae plants along with some biological activities and some regulations to conserve the native flora will be reviewed.

[Analysis of pharmacokinetics of kamelin in rat's blood plasma].

Camelyn is a new original biological preparation with strong immunomodulative and antioxidant effect. It is produced from special kind of honey. The features of original medicine camelyn for treatment of different types of infections and tumors and pharmacokinetics of camelyn in rat's plasma are described.

[Development of inhalation powder formulation of gentamicin sulphate].

Aminoglycosides, including gentamicin, are considered among the most useful classes of antibiotics for treating Pseudomonas aeruginosa infections. The major drawback of aminoglycosides is the need for their relatively high-dose intravenous administration, which carries the potential for systemic toxicity. Granulometry analysis of gentamicin sulfate powder (substance) has shown, that generally it consists of large particles, and thus is not suitable for inhalation.

[Dissolution study of the gentin tablets].

To establish individual dissolution test for the tablets gentin, which have a marked influence on the secretory function of the stomach (increase the free acidity of the gastric juice and stimulate enzymoproduction function of the stomach), and gastroprotective functioning, the conditions for the test realization were studied and specified, using apparatus "Rotating Basket" (Dissolution test, apparatus 1, p.1791, USP XXIII, 1995). For the quantification of the active ingredients in buffer solutions chromatospectrophotometric method was used.