Deep neural networks for wearable sensor-based activity recognition in Parkinson's disease: investigating generalizability and model complexity.

Background: The research gap addressed in this study is the applicability of deep neural network (NN) models on wearable sensor data to recognize different activities performed by patients with Parkinson's Disease (PwPD) and the generalizability of these models to PwPD using labeled healthy data.

Methods: The experiments were carried out utilizing three datasets containing wearable motion sensor readings on common activities of daily living. The collected readings were from two accelerometer sensors.

Exploring the feasibility of tensor decomposition for analysis of fNIRS signals: a comparative study with grand averaging method.

The analysis of functional near-infrared spectroscopy (fNIRS) signals has not kept pace with the increased use of fNIRS in the behavioral and brain sciences. The popular grand averaging method collapses the oxygenated hemoglobin data within a predefined time of interest window and across multiple channels within a region of interest, potentially leading to a loss of important temporal and spatial information. On the other hand, the tensor decomposition method can reveal patterns in the data without making prior assumptions of the hemodynamic response and without losing temporal and spatial information.

Dyskinesia Estimation of Imbalanced Data Using a Deep-Learning Model.

The collection of Parkinson's Disease (PD) time-series data usually results in imbalanced and incomplete datasets due to the geometric distribution of PD complications' sever-ity scores. Consequently, when training deep convolutional models on these datasets, the models suffer from overfitting and lack generalizability to unseen data. In this paper, we investigated a new framework of Conditional Generative Ad-versarial Netuwoks (cGANs) as a solution to improve the extrapolation and generalizability of the regression models in such datasets.

Activity Recognition in Parkinson's Patients from Motion Data Using a CNN Model Trained by Healthy Subjects.

Physical activity recognition in patients with Parkinson's Disease (PwPD) is challenging due to the lack of large-enough and good quality motion data for PwPD. A common approach to this obstacle involves the use of models trained on better quality data from healthy patients. Models can struggle to generalize across these domains due to motor complications affecting the movement patterns in PwPD and differences in sensor axes orientations between data.

The forecast of COVID-19 spread risk at the county level.

Unlabelled: The early detection of the coronavirus disease 2019 (COVID-19) outbreak is important to save people's lives and restart the economy quickly and safely. People's social behavior, reflected in their mobility data, plays a major role in spreading the disease. Therefore, we used the daily mobility data aggregated at the county level beside COVID-19 statistics and demographic information for short-term forecasting of COVID-19 outbreaks in the United States.

Dyskinesia estimation during activities of daily living using wearable motion sensors and deep recurrent networks.

Levodopa-induced dyskinesias are abnormal involuntary movements experienced by the majority of persons with Parkinson's disease (PwP) at some point over the course of the disease. Choreiform as the most common phenomenology of levodopa-induced dyskinesias can be managed by adjusting the dose/frequency of PD medication(s) based on a PwP's motor fluctuations over a typical day. We developed a sensor-based assessment system to provide such information.

Ensemble deep model for continuous estimation of Unified Parkinson's Disease Rating Scale III.

Background: Unified Parkinson Disease Rating Scale-part III (UPDRS III) is part of the standard clinical examination performed to track the severity of Parkinson's disease (PD) motor complications. Wearable technologies could be used to reduce the need for on-site clinical examinations of people with Parkinson's disease (PwP) and provide a reliable and continuous estimation of the severity of PD at home. The reported estimation can be used to successfully adjust the dose and interval of PD medications.

Detection of Mild Cognitive Impairment and Alzheimer's Disease using Dual-task Gait Assessments and Machine Learning.

Objective: Early detection of mild cognitive impairment (MCI) and Alzheimer's disease (AD) can increase access to treatment and assist in advance care planning. However, the development of a diagnostic system that d7oes not heavily depend on cognitive testing is a major challenge. We describe a diagnostic algorithm based solely on gait and machine learning to detect MCI and AD from healthy.

Dyskinesia Severity Estimation in Patients with Parkinson's Disease Using Wearable Sensors and A Deep LSTM Network.

Dyskinesias are abnormal involuntary movements that patients with mid-stage and advanced Parkinson's disease (PD) may suffer from. These troublesome motor impairments are reduced by adjusting the dose or frequency of medication levodopa. However, to make a successful adjustment, the treating physician needs information about the severity rating of dyskinesia as patients experience in their natural living environment.

Dual-Task Gait Assessment and Machine Learning for Early-detection of Cognitive Decline.

Alzheimer's disease (AD) affects approximately 30 million people worldwide, and this number is predicted to triple by 2050 unless further discoveries facilitate the early detection and prevention of the disease. Computerized walkways for simultaneous assessment of motor-cognitive performance, known as a dual-task assessment, has been used to associate changes in gait characteristics to mild cognitive impairment (MCI) with early-stage disease. However, to our best knowledge, there is no validated method to detect MCI using the collective analysis of these gait characteristics.

Tensor Decomposition of Functional Near-Infrared Spectroscopy (fNIRS) Signals for Pattern Discovery of Cognitive Response in Infants.

Functional near-infrared spectroscopy (fNIRS) provides an effective tool in neuroscience studies of cognition in infants. fNIRS signals are normally processed by applying ANOVA analysis on the grand average of the hemodynamic responses to investigate the cognitive-related differences between experimental groups. However, this averaging approach does not account for any differences in the temporal patterns of the responses.

Wearable Sensors for Estimation of Parkinsonian Tremor Severity during Free Body Movements.

Tremor is one of the main symptoms of Parkinson's Disease (PD) that reduces the quality of life. Tremor is measured as part of the Unified Parkinson Disease Rating Scale (UPDRS) part III. However, the assessment is based on onsite physical examinations and does not fully represent the patients' tremor experience in their day-to-day life.

Multilevel Features for Sensor-Based Assessment of Motor Fluctuation in Parkinson's Disease Subjects.

Motor fluctuations are a frequent complication in patients with Parkinson's disease (PD) where the response to medication fluctuates between ON states (medication working) and OFF states (medication has worn off). This paper describes a new data analysis approach that can be used along with two wearable IMU (inertial measurement units) sensors to continuously assess motor fluctuations in PD patients while moving in their natural environment. We hypothesized that joint analysis of the sensor data in its spectral, temporal and sensor domain could generate multilevel features that can be used to detect PD-related patterns successfully as the subject's motor state fluctuates between medication ON and OFF states.

Assessment of response to medication in individuals with Parkinson's disease.

Background And Objective: Motor fluctuations between akinetic (medication OFF) and mobile phases (medication ON) states are one of the most prevalent complications of patients with Parkinson's disease (PD). There is a need for a technology-based system to provide reliable information about the duration in different medication phases that can be used by the treating physician to successfully adjust therapy.

Methods: Two KinetiSense motion sensors were mounted on the most affected wrist and ankle of 19 PD subjects (age: 42-77, 14 males) and collected movement signals as the participants performed seven daily living activities in their medication OFF and ON phases.

Hybrid Feature Extraction for Detection of Degree of Motor Fluctuation Severity in Parkinson's Disease Patients.

The success of medication adjustment in Parkinson's disease (PD) patients with motor fluctuation relies on the knowledge about their fluctuation severity. However, because of the temporal and spatial variability in motor fluctuations, a single clinical examination often fails to capture the spectrum of motor impairment experienced in routine daily life. In this study, we developed an algorithm to estimate the degree of motor fluctuation severity from two wearable sensors' data during subjects' free body movements.

Deep Learning for Medication Assessment of Individuals with Parkinson's Disease Using Wearable Sensors.

Motor fluctuations between "OFF" state (with no benefit from medication) and " ON" state (with optimum benefit from medication) are a major focus of clinical managements in individuals with mid-stage and advance Parkinson's disease (PD). In this work, an automated algorithm based on Long Short-Term Memory (LSTM) as a deep learning method is developed to identify motor fluctuations in individuals with PD using wearable sensors during a variety of daily living activities. This network was evaluated on two datasets i.

Automatic assessment of medication states of patients with Parkinson's disease using wearable sensors.

Motor fluctuations are a major focus of clinical managements in patients with mid-stage and advance Parkinson's disease (PD). In this paper, we develop a new patient-specific algorithm that can classify those fluctuations during a variety of activities. We extract a set of temporal and spectral features from the ambulatory signals and then introduce a semi-supervised classification algorithm based on K-means and self-organizing tree map clustering methods.