Reference Database for a Novel Binocular Visual Function Perimeter: A Randomized Clinical Trial.

Purpose: To construct a comprehensive reference database (RDB) for a novel binocular automated perimeter.

Design: A four-site prospective randomized clinical trial.

Subjects And Controls: Three hundred fifty-six healthy subjects without ocular conditions that might affect visual function were categorized into 7 age groups.

Efficacy and Safety of CSF-1 (0.4% Pilocarpine Hydrochloride) in Presbyopia: Pooled Results of the NEAR Phase 3 Randomized, Clinical Trials.

Purpose: This study was undertaken to evaluate the safety and efficacy of CSF-1 (0.4% pilocarpine hydrochloride ophthalmic solution) for use in individuals with presbyopia.

Methods: Two Phase 3 multicenter, randomized, double-masked, vehicle-controlled, parallel-group clinical trials were conducted in 35 private ophthalmology clinics in the United States from October 2020 to February 2022.

Visual Field Artifacts in Glaucoma With Face Mask Use During the COVID-19 Pandemic.

Purpose: The coronavirus (COVID-19) pandemic has changed how outpatient care is delivered in ophthalmology clinics, particularly with glaucoma care. This case series highlights the need for awareness of fogging and improper face mask fit as causes of standard automated perimetry artifacts in patients with ocular hypertension and glaucoma.

Clinical Presentations: Six patients with the diagnosis of ocular hypertension, glaucoma suspect, or glaucoma underwent standard automated perimetry (24-2 or 10-2 SITA, Humphrey Field Analyzer) while wearing ear-loop surgical face masks.

Use of Topical Steroids in Conjunctivitis: A Review of the Evidence.

Purpose: Conjunctivitis, or inflammation of the conjunctiva, is a common condition that can be caused by infectious (eg, bacterial or viral infections) and noninfectious (eg, allergy) etiologies. Treatment involves diagnosis of the underlying cause and use of appropriate therapies. A broad-spectrum therapy that can address multiple etiologies, and also the accompanying inflammation, would be very useful.

Latanoprostene bunod ophthalmic solution 0.024%: a new treatment option for open-angle glaucoma and ocular hypertension.

Latanoprostene bunod (LBN) ophthalmic solution 0.024% is a novel, once-daily, nitric oxide-donating prostaglandin analogue for the lowering of intraocular pressure (IOP) in patients with open-angle glaucoma and ocular hypertension. The IOP-lowering actions of LBN are mediated by dual mechanisms of the molecule for increasing aqueous humour outflow.

The development of a reference database with the Topcon 3D OCT-1 Maestro.

Importance: The paper presents the range for measurements taken with a new spectral domain optical coherence tomography (OCT) device to establish a reference database for discrimination purposes.

Objective: To report the range of thickness values for the new Topcon Maestro 3D OCT device with 2 scan size settings: the 12×9 mm wide field and 6×6 mm scans.

Design: Prospective, multicenter cohort study conducted at 7 clinical sites across the USA.

The Role of Minimally Invasive Glaucoma Surgery Devices in the Management of Glaucoma.

Noncompliance is a problem affecting glaucoma patients. Approaches to improve adherence include the use of drug-delivery systems and safer forms of surgery. Minimally invasive glaucoma surgery (MIGS) has reduced complications, particularly in combination with cataract surgery, and with its good intraocular pressure (IOP) reduction may reduce or eliminate glaucoma medications.

Normative Databases for Imaging Instrumentation.

Purpose: To describe the process by which imaging devices undergo reference database development and regulatory clearance. The limitations and potential improvements of reference (normative) data sets for ophthalmic imaging devices will be discussed.

Method: A symposium was held in July 2013 in which a series of speakers discussed issues related to the development of reference databases for imaging devices.

The effects of race, optic disc area, age, and disease severity on the diagnostic performance of spectral-domain optical coherence tomography.

Purpose: To evaluate the effect of race (African or European descent), age, disc area, and severity of disease on the diagnostic ability of spectral-domain optical coherence tomography (SDOCT) imaging of the optic nerve, macula, and retinal nerve fiber layer (RNFL) in the detection of glaucomatous injury.

Methods: In this cross-sectional observational study, data from SDOCT images of 312 eyes of 167 subjects without ocular disease and 233 eyes of 163 patients with open-angle glaucoma. A receiver operating characteristic (ROC) regression modeling technique was used to evaluate the influence of race on the diagnostic accuracy of the ONH, RNFL, and macular parameters in SDOCT in glaucoma, while adjusting and evaluating the possible confounding effects of age, disease severity, and size of the optic disc.

Evaluation of screening versus regular polarimetry.

Purpose: The purpose of this study is to evaluate a new screening program for the GDx VCC (variable corneal compensation) retinal nerve fiber layer analyzer. This new method uses a fast screening approach to detect retinal nerve fiber layer loss associated with glaucoma. The study evaluates the sensitivity and specificity of the screening program and compares the results with those from the GDx VCC full examination.

Evaluation of decision rules for frequency-doubling technology screening tests.

Purpose: Frequency-doubling technology (FDT) perimetry has shown promise as a screening test for glaucoma. This study investigates different possible decision rules for FDT screening by applying them to groups of normal and glaucoma subjects.

Methods: Within three centers, 218 subjects (aged 15-88 years; 78 with glaucoma, 140 without ocular disease) were each tested twice with the screening program of the FDT perimeter.

Five rules to evaluate the optic disc and retinal nerve fiber layer for glaucoma.

A systematic approach for the examination of the optic disc and retinal nerve fiber layer is described that will aid in the detection of glaucoma. This approach encompasses 5 rules: evaluation of optic disc size, neuroretinal rim size and shape, retinal nerve fiber layer, presence of parapapillary atrophy, and presence of retinal or optic disc hemorrhages. A systematic process enhances the ability to detect glaucomatous damage as well as the detection of progression, and facilitates appropriate management.

Characteristics of the normative database for the Humphrey matrix perimeter.

Purpose: The Humphrey Matrix (Carl Zeiss Meditec, Dublin CA; Welch-Allyn, Skaneateles, NY) is a high-spatial-resolution perimeter that uses frequency-doubling stimuli. It incorporates an efficient test strategy that assumes that age, eccentricity, and test procedure type have only small effects on sensitivity. The results used to create the normative database for the perimeter were examined, to see whether these assumptions were met and to examine the form of the normative data.