Publications by authors named "Murk Heinemann"
Article Synopsis
- This study examines the impact of antibody-drug conjugates (ADCs) on refractive errors and keratopathy in cancer patients, specifically analyzing how certain corneal changes (microcyst-like epithelial changes or MECs) affect vision.
- Researchers conducted a retrospective analysis on 29 patients, focusing on changes in refractive error and keratometry during and after treatment with ADCs.
- Findings showed that peripheral MECs led to hyperopic shifts while central MECs caused myopic shifts, with many patients experiencing significant vision changes during treatment, although some returned to baseline after stopping the drug.
Importance: Fibroblast growth factor receptor (FGFR) 1 to 4 inhibitors are approved by the US Food and Drug Administration and suppress the mitogen-activated protein kinase (MAPK) pathway, with a potential for treatment-related retinopathy. To date, implications of FGFR inhibitor-associated ocular toxic effects are poorly described. Therefore, more detailed clinical descriptions of this ocular toxic effect could help explain visual symptoms while receiving drug therapy.
View Article and Find Full Text PDFPurpose: To investigate the clinical and morphologic characteristics of serous retinal disturbances in patients taking mitogen-activated protein kinase kinase (MEK) inhibitors.
Participants: A total of 313 fluid foci in 50 eyes of 25 patients receiving MEK inhibitors for treatment of their metastatic cancer, who had evidence of serous retinal detachments confirmed by optical coherence tomography (OCT).
Design: Single-center, retrospective cohort study.
Synthetic neurotensin analogues are nontoxic analgesics for the rabbit cornea.
Invest Ophthalmol Vis Sci
May 2014
Purpose: To characterize the analgesic potency and toxicity of topical synthetic neurotensin analogues, and localize neurotensin receptors in the cornea and trigeminal ganglion.
Methods: Cochet-Bonnet esthesiometry was performed on the rabbit cornea to test the analgesic dose response and duration of effect for two synthetic neurotensin analogues: NT71 and NT72. Receptors for neurotensin were localized in the murine cornea and trigeminal ganglion using quantitative PCR (qPCR), Western blotting, and immunohistochemistry.