Effects of adjuvant-induced arthritis on the ventral prostate of rats treated with angiotensin AT receptor blocker.

Aims: To analyze the prostatic compartments, extracellular matrix, microvascularization, transforming growth factor-beta (TGF-β) and angiotensin II receptors type 1 (AT) levels, and histopathology of the ventral prostate in a rat model for rheumatoid arthritis, and to evaluate the effect of angiotensin II AT receptor blocker (ARB) in the disease.

Main Methods: Fifteen male rats (90 days old) were divided into three groups (n = 5/group): control, adjuvant-induced arthritis without (AIA) or with AT receptor blocker (AIA + ARB). Animals were euthanized 60 days after immunization.