Publications by authors named "Murilo Machado"

Article Synopsis
  • Pesticide exposure is linked to an increased risk of diseases like breast cancer (BC), and the UGT2B7 gene variant rs7438135 (G > A) plays a role in detoxifying pesticides and potentially reducing oxidative stress.
  • A study examined 228 women with BC to see how their UGT2B7 variant affected oxidative stress caused by pesticide exposure, measuring specific markers in their plasma.
  • Results indicated that the rs7438135 variant did not provide protection against oxidative stress from pesticides, with significant lipid peroxidation and other stress markers observed in various aggressive tumor conditions.
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Studies have documented the high occurrence of several tumors, including female breast cancer, in populations occupationally exposed to pesticides worldwide. It is believed that in addition to direct DNA damage, other molecular alterations that indicate genomic instability are associated, such as epigenetic modifications and the production of inflammation mediators. The present study characterized the profile of inflammatory changes in the breast tissue of women without cancer occupationally exposed to pesticides.

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Objective: The aim of the study was to evaluate the rate of and risk factors for low pretreatment vitamin D (VitD) levels in postmenopausal breast cancer (BC) women, compared with postmenopausal women without BC.

Methods: A cross-sectional clinical study was conducted to compare 209 women with BC (case group) to 418 women without BC (control group), age range: 45 to 75 years. The case group consisted of women diagnosed with BC, amenorrhea ≥12 months, aged ≥45 years, without use of medication or clinical conditions that might interfere with VitD levels.

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This study aimed to evaluate the association between pretreatment vitamin D (VD) deficiency with breast cancer prognostic features in Brazilian postmenopausal women. An analytical cross sectional study was conducted with 192 women, aged 45-75 years, attended at University Hospital. Women with recent diagnosis of breast cancer, in amenorrhea >12months and age ≥45 years, without medication use or clinical conditions that interfere with VD values were included.

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This paper addresses the political actions of Anonymous, the principal expression of current hacker activism, arguing that hacktivism is a form of political resistance in control societies. To this end, it focuses on studying the Brazilian, hacktivist facet of the collective. In order to stress its political character, it scrutinizes the principal expressions of hacking in the literature.

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