Publications by authors named "Muriel Lalande"
Background: Aerobic fitness is a predictor of cardiovascular health which correlates with health-related quality of life in the general population. The aim is to evaluate the aerobic capacity by cardiopulmonary exercise test (CPET) in children with sickle cell disease in comparison with healthy matched controls.
Methods: Controlled cross-sectional study.
Article Synopsis
- A total of 52,588 RT-PCR tests for SARS-CoV-2 were conducted in France from March 2 to April 26, 2020, with 6,490 tests in children and 46,098 in adults.
- The positivity rate for SARS-CoV-2 was 5.9% in children compared to 20.3% in adults, indicating children had a lower rate of infection.
- The overall risk ratio for adults testing positive compared to children was 3.5, suggesting adults were significantly more likely to test positive throughout the study period.
Objective(s): To describe the clinical, virological and immune characteristics of internationally adopted children on arrival in France and after 6-months follow-up.
Design: Multicenter retrospective study.
Methods: 30 centers from 24 cities were asked to include, after informed consent, HIV+ children living in France and internationally adopted between 1st Jan 2005 and 1st Jan 2015.
Article Synopsis
- The study focused on assessing the benefits and risks of treatment interruption (TI) in children with chronic HIV-1 from maternal transmission.
- Conducted in five pediatric departments in France, it analyzed clinical data from 24 patients, looking at various health metrics before and during TI.
- Results showed that after 40 weeks of TI, none of the children experienced AIDS-defining events, but there was a notable increase in viral load and a significant CD4 cell loss, indicating that careful monitoring is essential during TI in this population.