[Combined intravenous and epidural anesthesia in laparoscopic surgery].

Two methods of anesthesia (total intravenous and combined intravenous + epidural) are compared in patients after laparoscopic cholecystectomy with grave concomitant diseases of the circulatory and respiratory systems. Combined anesthesia should be preferred in this category of patients.

[Pathomorphosis of cancer of the breast during thermoradiotherapy].

Local UHF-hyperthermia in combined therapy of breast cancer patients as compared to preoperative radiotherapy used alone, resulted in more noticeable therapeutic changes in a tumor. This fact was established during a study of tumor pathomorphosis in 206 patients with stage II breast cancer. A degree of therapeutic tumor pathomorphosis showed good correlation with the frequency and duration of a recurrence-free period of disease.

[Intracavity gamma therapy of microcarcinoma of the cervix uteri].

The results of therapy of 2 groups of patients with microinvasive cervical carcinoma were analyzed. Intracavitary gamma-beam therapy at single doses of 5 and 10 Gy and cumulative doses of 40 and 30 Gy, respectively, with the Agat-B remote loading unit was applied to 95 patients (the 1st group). Wertheim's operation (radical hysterectomy) was performed on 62 patients (the 2nd group).

[Basement membranes in precancerous conditions and neoplasms of the uterine cervix].

By routine histological staining technics and histochemical assays under an appropriate enzymic control the author has studied changes in the basement membranes of the uterine cervix in its precancer and cancer as compared with the normal state. Changes in the basement membranes, revealed morphologically, reflect objectively the status of the epithelium and stroma during the period of tumor origination and growth, and therefore these may serve as a valuable adjunct to the differential microscopic diagnosis of dysplasia, preinvasive cancer and an incipient invasive growth. It is believed that basement membrane neoplasms may develop around mostly differentiated complexes of cancer cells in far-advanced neoplasms and their metastases; this fact is regarded as a tendency to normalization of the relationship between the cancerous tumor parenchyma and stroma with correlations between them being remined even under extremely unfavourable conditions of the tumor growth.

[Morphogenesis of cervical cancer].

The origination and development of cervical cancer occurs in the tumor field, which includes cellular and non-cellular components of the connective tissue and vessels adjacent to the epithelium. During each of these phases of cancer growth alterations in these components may be observed within certain boundaries which widen with the tumor progression. A removal of the neoplasm within the limits of the unchanged, as compared with the normality, components of the stroma and vessels would guarantee against the recurrence and is a reliable criterion of the radicality of surgery being a minimum for preinvasive and microinvasive cancer.

[Elastic fibers of the cervical stroma in precancer and cancer].

Along with the description of the architectonics of elastic fibres in normal cervicovaginal tissues the kinetics of their changes was followed in precancerous conditions and cancer of the cervix. It was found that during the process of growth and development of precancerous lesions and cancer elastic fibres would undergo a number of gradually increasing changes from surface, reversible to profound, irreversible with their ultimate total destruction.