Publications by authors named "Murat Karapapak"

Article Synopsis
  • The study compares macular vessel density (VD) in patients with macula-off rhegmatogenous retinal detachment (RRD) who underwent vitrectomy using either gas or silicone oil (SO) tamponade.
  • Fifty patients participated, and results showed that both groups had significant improvements in best-corrected visual acuity (BCVA) after surgery, but the gas tamponade group had better outcomes.
  • The silicone oil group had lower VD in certain retinal layers, indicating possible toxic effects on macular perfusion, while gas tamponade appeared to preserve VD, suggesting a preference for gas tamponade in these cases.
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Article Synopsis
  • The study aimed to compare macular displacement (MD) rates in patients with macula-off retinal detachments who had surgery using either silicone oil or C3F8 gas tamponade and to analyze its relationship with visual distortion (metamorphopsia).
  • A total of 53 patients were included, with 28 receiving C3F8 gas and 25 receiving silicone oil, and the results showed a significant difference in MD rates between the two groups.
  • The findings indicated that while MD occurred in both groups, it did not consistently correlate with the presence of metamorphopsia, suggesting that not all patients with MD experience visual distortions post-surgery.
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Purpose: To assess the appropriateness and readability of responses provided by four large language models (LLMs) (ChatGPT-4, Claude 3, Gemini, and Microsoft Co-pilot) to parents' queries pertaining to retinopathy of prematurity (ROP).

Methods: A total of 60 frequently asked questions were collated and categorized into six distinct sections. The responses generated by the LLMs were evaluated by three experienced ROP specialists to determine their appropriateness and comprehensiveness.

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Objectives: To compare the pain perception and treatment duration in patients undergoing panretinal photocoagulation (PRP) for high-risk proliferative diabetic retinopathy (PDR) using Navilas laser versus conventional laser.

Methods: A study was conducted involving 40 patients with bilateral high-risk PDR. Each patient underwent PRP with conventional laser in one eye and Navilas laser in the other.

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Objective: In this study, we aimed to compare choroidal vascular changes using the Choroidal Vascularity Index (CVI) between patients with inactive Thyroid Eye Disease (iTED) and healthy individuals, and to assess the relationship between CVI and choroidal thickness (CT), smoking history, and clinical parameters.

Methods: In this cross-sectional observational study, the eyes of 30 patients aged 18 to 45 with iTED were compared with the randomly selected eyes of 35 age and gender-matched healthy control individuals. Optical coherence tomography (OCT) scans were taken from all participants.

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Objectives: The objective of the study was to evaluate the prevalence and potential risk factors associated with retinopathy of prematurity (ROP) in very low birth weight (BW) ROP patients stratified by different BW categories.

Methods: This retrospective cohort study examined very low BW patients (≤1500 g) treated at a neonatal intensive care unit and subsequently assessed for ROP at the outpatient clinic. Data on gestational age (GA), BW, ROP severity, treatments, and outcomes were collected following international ROP classification criteria.

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Purpose: This study aimed to assess and compare the retinal toxicity associated with silicone oil (SO) and perfluoropropane (C3F8) tamponade following vitreoretinal surgery for fresh rhegmatogenous retinal detachment (RRD), utilizing the office-based Diopsys NOVA system for evaluation.

Methods: Patients who underwent vitreoretinal surgery for fresh RRD and had SO (group 1) or C3F8 (group 2) tamponade were included in a prospective analysis. Flicker full field electroretinography (ffERG) and pattern electroretinography (PERG) tests were performed at 6 months postoperatively.

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Purpose: To investigate the value of proprotein-converting subtilisin kexin type 9 (PCSK9) levels in type 2 diabetes mellitus (T2D) patients with different stages of diabetic retinopathy (DR) and to compare these findings with a healthy control group without diabetes mellitus (DM).

Methods: A total of 135 patients, 100 of whom were patients with T2D and 35 of whom were in the health control group, were included in this prospective study. T2D patients were divided into three groups: the first group included 34 people with T2D without DR, the second group had 32 people with non-proliferative DR (NPDR), and the third group had 34 people with proliferative DR (PDR).

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Purpose: It was aimed to compare corneal endothelial changes during the initial 12-month period in which patients started using atorvastatin after a diagnosis of acute coronary syndrome (ACS).

Methods: Forty-six participants (group 1) who underwent cardiac angioplasty and stenting for ACS and started using 80 mg atorvastatin in the early period were included in the study. In the study, a control group comprising 71 healthy adults (group 2) was included.

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Purpose: To compare short-term changes in corneal endothelial cells after gonioscopy-assisted transluminal trabeculotomy(GATT).

Methods: This retrospective comparative study included 138 patients(138 eyes), and 98 of these patients underwent GATT procedure and 40 underwent SLT procedure as a control group. Changes in the corneal endothelium in patients who underwent GATT and SLT were analyzed retrospectively.

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Purpose: To compare the complications and postoperative outcomes of Nd:YAG laser anterior capsulotomy vs a needle aspiration approach for capsulorhexis in patients with intumescent cataracts.

Setting: University of Health Sciences, Basaksehir Cam and Sakura City Hospital Department of Ophthalmology, Istanbul, Turkey.

Design: Retrospective, cross-sectional study.

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Purpose: To evaluate the structural and microvascular changes in the retina and choroid after strabismus surgery.

Methods: The study included 44 eyes from 44 patients who underwent strabismus surgery between August 2020 and December 2021. Among these patients, 9 (20%) underwent horizontal one-muscle surgery, 27 (61%) underwent horizontal two-muscle surgery, and 8 (18%) underwent inferior oblique muscle anteriorization surgery.

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Purpose: To assess the positive effects of mindfulness-based stress reduction (MBSR) on the structural and functional outcomes of patients with central serous chorioretinopathy (CSCR).

Methods: This study included 60 patients with CSCR who were randomly allocated to one of two groups: MBSR or control (which did not practice MBSR). These groups were then evaluated in terms of best corrected visual acuity (BCVA) and central macular thickness (CMT) at months 1, 3, and 6.

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Purpose: To compare the efficacy of gonioscopy-assisted transluminal trabeculotomy (GATT) versus micropulse transscleral diode laser cyclophotocoagulation(MP-TDLC) combined with GATT in the treatment of advanced glaucoma.

Methods: This retrospective comparative study study included 82 patients (82 eyes) with a diagnosis of advanced glaucoma: 36 patients underwent GATT, and 46 underwent GATT + MP-TDLC. Intraocular pressure (IOP) changes in patients who underwent GATT and GATT MP-TDLC were analyzed retrospectively at regular intervals during the 6-month follow-up period.

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Objectives: The aim of the study was to evaluate the outcomes and complications associated with PAUL glaucoma implant (PGI) surgery in pseudoexfoliation glaucoma (PXG) patients, comparing them with a primary open-angle glaucoma (POAG) control group.

Methods: A retrospective analysis included 39 PXG and 29 POAG eyes undergoing PGI surgery between January 2020 and December 2022. Surgical success was defined as intraocular pressure (IOP) between ≤21 and ≥6 mmHg at 12 months and no loss of light perception.

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Article Synopsis
  • The study aimed to assess how carotid artery stenting and angioplasty (CASA) influence retinal vascular density (VD) in patients with severe carotid stenosis compared to healthy individuals using optical coherence tomography angiography (OCTA).
  • It included 40 patients with ipsilateral carotid artery stenosis and analyzed changes in VD of the superficial (SCP) and deep capillary plexus (DCP) before and after the procedure.
  • Results showed no significant changes in SCP VD across all groups, but a noticeable improvement in DCP VD was observed in both ipsilateral and contralateral groups post-CASA, suggesting OCTA can be a useful tool for monitoring treatment effects in CAS patients.
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Prcis: Longer-term studies with a larger sample size are needed to demonstrate the superiority or equivalence of these procedures.

Objective: To evaluate the outcomes of the PAUL glaucoma implant (PGI) and Ahmed glaucoma valve (AGV) in patients with secondary glaucoma caused due to silicone oil emulsification.

Patients And Methods: A retrospective examination was conducted using the medical records of 36 patients who developed secondary glaucoma due to silicone oil emulsification after vitreoretinal surgery and then underwent PGI and AGV implantation surgery.

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Article Synopsis
  • The study investigated the systemic and ocular side effects of favipiravir (FAV), an antiviral drug for COVID-19, using 18 male Wistar rats divided into three groups with different FAV doses.
  • Results showed that the high dose group (FAV200) had increased levels of malondialdehyde, interleukin-1β, and tumor necrosis factor alpha, indicating oxidative stress and inflammation compared to the healthy control group.
  • Histopathological examinations revealed significant damage to the conjunctiva and sclera in the FAV200 group, suggesting that high doses of FAV can adversely affect eye health in rats.
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Objectives: To evaluate the efficiency and safety of autologous blood-assisted, sutureless conjunctival autograft surgery in the management of pterygium.

Methods: This study included the eyes of 124 patients who were divided into two groups. Group 1 consisted of 62 patients who received autologous blood-assisted, sutureless conjunctival autograft, and Group 2 consisted of 62 patients who underwent conventional sutured conjunctival autograft surgery.

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Background: Using OCT and OCTA imaging, we aimed to determine whether COVID-19 induces pathological changes in vascular and morphological structures in the pediatric retina.

Methods: The current prospective, cross-sectional, observational clinical study included recovered pediatric patients with COVID-19 evaluated between May 2020 and June 2020. Retinal vascular (radial peripapillary, superficial, and deep capillary plexus vessel densities) and morphological (peripapillary retinal nerve fiber, ganglion cell layer, retinal, and choroidal thickness) in the optic disk and macula regions were quantitively assessed using OCT and OCTA.

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Objectives: The purpose of the study was to evaluate the effect of different treatment modalities on refractive outcomes in patients treated with severe retinopathy of prematurity (ROP).

Methods: The records of children who were treated for severe ROP in our clinic between January 2015 and August 2018 were retrospectively reviewed. The children who were treated were analyzed in three subgroups as intravitreal bevacizumab (IVB), laser photocoagulation (LPC), and IVB + LPC.

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Purpose: To compare the efficacy and safety of cold saline solution (0.9% NaCl) with topical ophthalmic proparacaine for maintaining topical anesthesia of patients undergoing phacoemulsification surgery.

Methods: The prospective, double-blinded, and randomized clinical study was randomly assigned to two groups that underwent phacoemulsification surgery due to cataracts.

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Aim And Objective: To evaluate the efficacy and safety of XEN stent implantation in the inferonasal quadrant after prior failed trabeculectomy.

Materials And Methods: Fourteen open-angle glaucoma patients with prior failed trabeculectomy were recruited to this retrospective study. Implantation of the stent was performed as a stand-alone procedure.

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Objectives: In the current study, we aimed to investigate retinal vascular density and blood flow changes in patients with chronic obstructive pulmonary disease (COPD) using optical coherence tomography angiography (OCTA) (AngioVue Avanti, Optovue).

Methods: Thirty eyes of 30 patients with COPD and 30 eyes of 30 healthy controls were evaluated with OCTA. Foveal and parafoveal vessel density, inner retinal and choriocapillary flow area, and foveal avascular zone (FAZ) area were measured and compared between the groups.

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