NO Addition during Gas Oxygenation Reduces Liver and Kidney Injury during Prolonged Cardiopulmonary Bypass.

. To evaluate the effect of NO added to the sweep gas of the oxygenator during cardiopulmonary bypass (CPB) on the liver and kidneys in pigs. .

[Psychological and mental aspects of increased tooth abrasion].

The analysis of literary and other information sources (in PubMed, Google Scholar, KiberLeninka and eLibrary databases) devoted to the study of dental manifestations of psychological conditions and the analysis of the ability of dentists to identify psychological predictors of increased tooth erasure in adolescents and young people. Disorders such as stress, depression, attention deficit hyperactivity disorder, alcohol dependence, eating disorders - may be risk factors for the development of increased tooth abrasion. Comorbid conditions such as bruxism and gastroesophageal reflux are also considered.

Acute Effect of Selective Chemical Inactivation of Sympathetic or Parasympathetic Atrial Ganglionated Plexus Structures on Atrial Fibrillation Inducibility in Pigs.

We studied the role of both parts of the autonomic intracardiac nervous system in the pathogenesis of atrial fibrillation (AF). In 12 pigs weighing 39±3 kg, AF was induced by burst stimulation. Chemical inactivation of intrinsic cardiac neurons within the right atria was performed by transendocardial injections of liposomal neuromodulators into the dorsal part of the right atrial wall.

Satellite Glial Cells: Morphology, functional heterogeneity, and role in pain.

Neurons in the somatic, sympathetic, and parasympathetic ganglia are surrounded by envelopes consisting of satellite glial cells (SGCs). Recently, it has become clear that SGCs are highly altered after nerve injury, which influences neuronal excitability and, consequently, the development and maintenance of pain in different animal models of chronic pain. However, the exact mechanism underlying chronic pain is not fully understood yet because it is assumed that SGCs in different ganglia share many common peculiarities, making the process complex.

Heterogeneity and Potency of Peripheral Glial Cells in Embryonic Development and Adults.

This review describes the heterogeneity of peripheral glial cell populations, from the emergence of Schwann cells (SCs) in early development, to their involvement, and that of their derivatives in adult glial populations. We focus on the origin of the first glial precursors from neural crest cells (NCCs), and their ability to differentiate into several cell types during development. We also discuss the heterogeneity of embryonic glia in light of the latest data from genetic tracing and transcriptome analysis.

The zebrafish model system for dyslipidemia and atherosclerosis research: Focus on environmental/exposome factors and genetic mechanisms.

Dyslipidemias and atherosclerosis play a pivotal role in cardiovascular risk and disease. Although some pathophysiological mechanisms underlying these conditions have been unveiled, several knowledge gaps still remain. Experimental models, both in vitro and in vivo, have been instrumental to our better understanding of such complex processes.

Transcatheter radiofrequency pulmonary artery denervation in swine: the evaluation of lesion degree, hemodynamics and pulmonary hypertension inducibility.

Background: Mechanisms of positive effects of pulmonary artery (PA) denervation (PADN) remain poorly understood. The study aimed to evaluate pulmonary hemodynamic changes after PADN and their association with the extent of PA wall damage in an acute thromboxane A2 (TXA2)-induced pulmonary hypertension (PH) model in swine.

Methods: In this experimental sham-controlled study, 17 normotensive male white Landrace pigs (the mean weight 36.

Modeling of Acute Pulmonary Arterial Hypertension in Pigs Using a Stable Thromboxane A Analogue (U46619): Dose Adjustment and Assessment of Hemodynamic Reactions.

U46619, a synthetic analogue of thromboxane A2 was used for modeling acute stable and reversible pulmonary arterial hypertension. Administration of U46619 in high doses led to vascular collapse and inhibition of cardiac function. The doses of U46619 were empirically selected that allow attaining the target level of pulmonary hypertension without systemic hemodynamic disturbances.

Perivascular Innervation of the Pulmonary Artery in Human and Swine: A Comparative Study for the Development of an Experimental Model of Denervation.

For studying the possibility of using catheter denervation of the pulmonary artery for the treatment of pulmonary hypertension, large animals, such as pigs, are more suitable, because the diameter of the pulmonary artery in this case allows manipulation of the ablation catheter. The study of the perivascular adipose tissue of the trunk and bifurcation of the pulmonary artery in humans and pigs revealed differences in the density and diameter of nerve fibers, but their depth did not differ. Immunohistochemical analysis with different markers of the autonomic nervous system receptors revealed similar receptor profile in human and pigs, though the expression of all studied markers in pigs was less pronounced than in humans.

[The effect of glucose level in blood on microbiocenosis of intestine and quality of life of people with predisposition to diabetes mellitus type II.].

The article presents analysis of results of examination of spectrum, rate of occurrence and number of microorganisms of large intestine in individuals with normal level of glucose in blood and with predisposition to diabetes mellitus type II. The psychodiagnostic study was carried out including estimate of particular psycho-physiologic and social psychological characteristics of personality reflecting characteristics of psychic and social development. It is established that in individuals with predisposition to diabetes mellitus type II microbiota of intestine altered sideway to dysbiosis degree I-II at the expense of increasing of number of opportunistic microflora up to several degrees.

Immunogenetic Factors of Predisposition to Blood Malignancies in Russian Population.

HLA class II loci (DRB1, DQB1) have been investigated in patients with different blood tumors: acute myelogenous leukemia, acute lymphoblastic leukemia, chronic myelogenous leukemia and Hodgkin's disease. The purpose was to determine the general (common) markers of predisposition (or resistance) in HLA class II loci to malignant changing of hemopoiesis in Russian population, and to verify the individual associations between HLA and disease for each examined neoplasm. It has been found that: 1).

[Search for non-relative donor by the Russian register of bone marrow donors].

Aim: To select maximally HLA compatible donor for hematological patients who need transplantation of bone marrow from non-relative donor.

Materials And Methods: 75 patients with hematological malignancy were observed. All of them have indications to non-relative transplantation of the bone marrow.

[Forensic medical expert evaluation of lethal poisoning with narcotics].

Morphological manifestations of lethal narcotic poisoning are analyzed on the basis of results presented in "Acts of Medical Examination of Corpse" and "Expert Conclusions" on 352 cases with lethal narcotic poisoning, suspected (with good grounds) poisoning, and combined poisoning with narcotics and other agents. Causes of failure to detect narcotics in forensic chemical analysis of biological material from the corpse are enumerated.