Publications by authors named "Murashima A"
Aim: Uncontrolled chronic inflammatory diseases (CIDs) before, during, and after pregnancy, as well as some CID medications, can increase the risk of impaired fertility in addition to adverse maternal/pregnancy outcomes in women of childbearing age. We report pregnancy outcomes from prospectively reported pregnancies in Japanese women treated with certolizumab pegol (CZP).
Methods: Data from July 2001 to November 2020 on CZP-exposed pregnancies from the CZP Pharmacovigilance safety database were reviewed.
We evaluated the teratogenic risk associated with exposure to cefditoren pivoxil during the first trimester of pregnancy using the integrated databases of the Toranomon Hospital and the National Center for Child Health and Development. Among 13 599 registered individuals, the analysis included 285 subjects who had taken cefditoren pivoxil during the first trimester of pregnancy. The rates of stillbirth, miscarriage, and elective terminations were 0.
View Article and Find Full Text PDFEffects of famotidine use during pregnancy: an observational cohort study.
J Pharm Health Care Sci
November 2024
Background: Famotidine, a histamine2-receptor antagonist (H2Ras), is widely used to treat and prevent gastrointestinal symptoms during pregnancy. Although several studies have reported the use of H2Ras during pregnancy, limited data on famotidine were included in these reports. Therefore, we analyzed pregnancy outcome data to evaluate the effects of famotidine use during pregnancy on the fetus.
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- - The study investigates the challenges that nurses encounter when caring for older patients with rheumatoid arthritis (RA) in Japan, using responses from certified nurses to identify key issues.
- - A total of 182 specific challenges were categorized into seven components, focusing on patient-related issues such as comprehension, support, comorbidities, and financial constraints, as well as challenges faced by nurses themselves.
- - The findings highlight the need for better patient understanding, improved nurse training, and enhanced support systems, emphasizing the importance of teamwork and family involvement in patient care.
Objective: This systematic scoping review assess the effect of cyclophosphamide (CY) administration during childhood on ovarian function in patients with juvenile-onset connective tissue diseases.
Methods: A MEDLINE database search was conducted using terms related to CY, juvenile-onset connective tissue diseases, and ovarian function. Studies were included if they met specific criteria.
The study evaluated the regenerative responses of the lacrimal functional unit (LFU) after lacrimal gland (LG) ablation. The LG of Wistar rats was submitted to G1) partial LG ablation, G2) partial ablation and transplantation of an allogeneic LG, or G3) total LG ablation, (n = 7-10/group). The eye wipe test, slit lamp image, tear flow, and histology were evaluated.
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- Cefcapene pivoxil hydrochloride is an antibiotic commonly used by pregnant women, but its safety during the first trimester has not been previously studied.
- This research compared the incidence of major malformations in infants born to women who took this antibiotic (2.6%) versus those who used control drugs (1.8%), using data from two Japanese facilities between 1988 and 2017.
- The study found no significant difference in major malformation rates between the groups, suggesting that cefcapene pivoxil hydrochloride does not increase malformation risks and can inform healthcare providers on medication choices during pregnancy.
Article Synopsis
- A study was conducted in Japan to assess the safety of fluoroquinolone antibiotics during pregnancy, focusing on major congenital anomalies in babies born to mothers who used these drugs in their first trimester.
- The study included 411 women exposed to fluoroquinolones and compared them with 1416 women using β-lactams and 1482 women using nonteratogenic medications.
- Results showed the incidence of major congenital anomalies was similar across all groups (1.5% for fluoroquinolones, 2.0% for β-lactams, 1.6% for nonteratogenic drugs), indicating that fluoroquinolone exposure does not significantly increase the risk of congenital anomalies.
Article Synopsis
- The study focused on identifying the challenges faced by nurses in Japan when caring for pediatric patients with juvenile idiopathic arthritis (JIA).
- It involved 89 certified nurses who reported various issues, resulting in five main challenge categories: communication, understanding, expertise, system, and collaboration, with differences noted between JIA patients and adults with rheumatoid arthritis.
- The findings emphasize the need for multidisciplinary care and a better understanding of the complexities involved in patient and guardian dynamics to enhance treatment outcomes and overall quality of life.
Background: Undernutrition and underweight are osteoporosis risk factors. Therefore, improving the health of underweight young women in Japan is an important medical issue. However, few studies have evaluated the association between being preconception underweight and postnatal osteoporotic fractures in young women.
View Article and Find Full Text PDFDecalobanthus peltatus is a woody vine that is commonly utilized in traditional Southeast Asian medicinal preparations. Despite the documented therapeutic uses of D. peltatus, there is hardly any information regarding its toxic effects on its consumers.
View Article and Find Full Text PDFObjectives: A quality indicator (QI) for the treatment of systemic lupus erythematosus (SLE) during pregnancy and childbirth that is useful for sharing standard treatment policies has not yet been developed. This study aimed to develop a QI for SLE associated with pregnancy and childbirth.
Methods: To identify candidate QIs, we conducted a systematic literature review on the development of QIs for SLE related to pregnancy and childbirth and on clinical practice guidelines.
To assess the risk of major birth defects after first-trimester exposure to carbocisteine and ambroxol during pregnancy, we conducted a prospective cohort study using counseling data for drug use during pregnancy provided by the Japan Drug Information Institute in Pregnancy and Toranomon Hospital. Counseling information, including drug usage and participants' demographic information, was collected between April 1988 and December 2017. Pregnancy outcome data, including major birth defects, were obtained using a questionnaire administered 1 month after delivery.
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- The study aimed to address the challenges faced by pregnant patients with inflammatory rheumatic diseases (RDs) and improve medical services from their perspective.
- A survey was conducted with about 5,000 members of the Patients Association for Collagen Vascular Diseases Japan, resulting in 491 completed questionnaires focusing on pregnancy experiences and challenges among patients with RDs.
- Key findings showed that 60% of participants faced pregnancy-related issues, particularly concerns about medications and disease activity, highlighting the need for better support and information for patients dealing with RDs during pregnancy.
Background: It is unclear witch regimen is optimal as salvage chemotherapy (SCT) after immune checkpoint inhibitor (ICI) monotherapy for recurrent or metastatic head and neck cancer (RM-HNC).
Methods: This study enrolled 109 patients. Overall survival (OS) and progression-free survival 2 (PFS2) were compared between patients stratified by SCT regimen.
Article Synopsis
- Pregnant women are often not included in clinical trials, making post-marketing data vital to understand medication impacts on fetuses; hence, JDIIP was created to gather this information.
- The study assessed JDIIP’s consultation cases to improve the quality of clinical information for pregnancy medication use and evaluated the adequacy of medication details in Japanese package inserts.
- While follow-up surveys showed an 83.1% response rate, the overall number of consultations is low despite an increase in facilities, highlighting the need for more awareness and data collection strategies related to medication use in pregnancy.
Background: Inhibitors of apoptosis proteins (IAPs) modulate the inflammatory process, and may facilitate the formation of chronic rhinosinusitis with nasal polyps (CRSwNP). This study aimed to observe if IAPs were differently expressed between patients with CRSwNP and controls, and to correlate the expression of IAPs with some inflammatory markers, as with the response to nasal corticosteroids in patients with CRSwNP.
Methodology: We obtained nasal biopsies from patients with CRSwNP (n=27) and controls (n=16).
Background: Although the COVID-19 pandemic has increased the prevalence of cases with olfactory loss, other respiratory viruses can also cause this condition. We aimed to compare the prevalence of acute SARS-CoV-2 infection and other respiratory viruses in patients with sudden smell loss, and to assess the impact of SARS-CoV-2 viral load and co-infection on olfactory symptoms.
Methods: Patients with sudden smell loss were recruited in a multicenter prospective cohort study in 15 hospitals in Brazil.
Article Synopsis
- Drug therapy in pregnancy and lactation involves weighing the potential risks against the benefits for both the mother and the baby.
- *Effective management of medical conditions during pregnancy is crucial for a positive pregnancy outcome.
- *The lecture will cover foundational ideas related to drug therapy in these specific situations.
Article Synopsis
- The study investigates the racial characteristics and clinical features of perinatal thrombotic microangiopathy in a specific group of patients at a perinatal center in Japan over five years.
- Out of 10,224 deliveries, only seven cases (0.06%) of perinatal thrombotic microangiopathy were identified, with notable factors including a low median pre-pregnant body mass index and a high incidence of in-vitro fertilization.
- The findings suggest that medical complications and twin pregnancies could be potential risk factors for this condition among Japanese women, highlighting variability in onset based on underlying causes.
Article Synopsis
- The study aimed to find a simpler way to collect and analyze breast milk for the presence of biologics, which are drugs that may be used by nursing mothers.
- Researchers used a method involving dried filter paper samples to measure drug concentrations over a 28-day period, ensuring accurate results.
- The findings suggest that this method is reliable and can help improve medication management for lactating women who need biologic therapies.
Objectives: This study aimed to identify the challenges faced by nurses engaged in rheumatology care in Japan.
Methods: We conducted a questionnaire survey of nurses in Japan in 2020 on challenges experienced in rheumatology care. The participants were nurses certified by the Japan Rheumatism Foundation.
Article Synopsis
- The study aimed to assess the effectiveness of intravenous immunoglobulin (IVIG) therapy for patients with obstetric antiphospholipid syndrome (APS) who did not respond to standard treatments.
- In the clinical trial, patients received a 5-day course of IVIG alongside their conventional treatments, with the main goal of achieving live births after 30 weeks of pregnancy.
- Results showed that while IVIG alone did not significantly improve live birth rates, combining it with other therapies led to better pregnancy outcomes for many patients, indicating a need for further research on multi-targeted treatment approaches for obstetric APS.
Objective: The European League Against Rheumatism recommends that the disease activity of systemic lupus erythematosus should be stable before pregnancy because complications and disease flares increase if pregnancy occurs while disease activity is high. However, some patients have ongoing serological activity even after treatment. Herein, we investigated how physicians decide on the acceptability of pregnancy in patients showing only serological activity.
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