Intestinal flora altered and correlated with interleukin-2/4 in patients with primary immune thrombocytopenia.

Background: Little is known about the changes and mechanisms of intestinal flora in primary immune thrombocytopenia (ITP) patients.

Aim: To explore the structural and functional differences of intestinal flora between ITP patients and healthy controls, and clarify the correlation between intestinal flora and Th1/Th2 imbalance.

Methods: Feces from ITP patients and healthy controls were studied by 16S rRNA and metagenomic techniques at phylum, genus, species or functional levels.