Tripodal Quinone-Cyanine G-Quadruplex Ligands as Novel Photosensitizers on Photoinduced Cancer Cell Death.

Guanine-quadruplex (G4) selective photosensitizers have huge potential for photodynamic therapy against various diseases correlated with G4 DNA and G4 RNAs; however, the types of photosensitizer skeletons available are limited. Herein, we investigated the ability of our original G4 ligands, tripodal quinone-cyanine dyes (tpQCy(s)), which were developed as fluorescent probes for G4, to act as photosensitizers for cancer-selective apoptosis inducers. The results indicated that the tpQCy skeleton has great potential for developing G4-targeted cancer-selective photosensitizers for photodynamic therapy.

Near-Infrared Fluorescent Switch-On Probe for Guanine-Quadruplex Imaging with Extremely Large Stokes Shift.

To visualize the guanine-quadruplex (G4) nucleic acids in cells or in biological tissues, near-infrared (NIR) fluorescent probes that can respond specifically to G4 nucleic acids are required. Herein, an NIR fluorescence switch-on probe for G4 imaging having higher selectivity and extremely large Stokes shift (ca. 220 nm) was successfully developed by the modification of our original tripodal quinone-cyanine fluorescent dye.

Real-Time Observation of Charge-Spin Cooperative Dynamics Driven by a Nonequilibrium Phonon Environment.

We report on experimental observations of charge-spin cooperative dynamics of two-electron states in a GaAs double quantum dot located in a nonequilibrium phonon environment. When the phonon energy exceeds the lowest excitation energy in the quantum dot, the spin-flip rate of a single electron strongly enhances. In addition, originated from the spatial gradient of phonon density between the dots, the parallel spin states become more probable than the antiparallel ones.

Nitrogen mineralization from organic fertilizers and composts: Literature survey and model fitting.

Organic fertilizers and composts are valuable sources of nutrients. However, their nutrient availability is often not known and can be variable. The objective of the present study was to collect net nitrogen (N) turnover data from peer-reviewed articles and fit a model that simulates gross N mineralization and gross N immobilization to determine pool sizes and their rate constants of different common organic amendments.

Analysis of Environmental Variables and Carbon Input on Soil Microbiome, Metabolome and Disease Control Efficacy in Strawberry Attributable to Anaerobic Soil Disinfestation.

Charcoal rot and Fusarium wilt, caused by and f. sp. , respectively, are major soil-borne diseases of strawberry that have caused significant crop losses in California.

Giant magneto-optical responses in magnetic Weyl semimetal CoSnS.

The Weyl semimetal (WSM), which hosts pairs of Weyl points and accompanying Berry curvature in momentum space near Fermi level, is expected to exhibit novel electromagnetic phenomena. Although the large optical/electronic responses such as nonlinear optical effects and intrinsic anomalous Hall effect (AHE) have recently been demonstrated indeed, the conclusive evidence for their topological origins has remained elusive. Here, we report the gigantic magneto-optical (MO) response arising from the topological electronic structure with intense Berry curvature in magnetic WSM CoSnS.

Assessing Anaerobic Soil Disinfestation as a Control Tactic for Delia radicum (Diptera: Anthomyiidae) in California Brussels Sprouts.

Fumigants are often the primary material used to manage plant disease agents, soil-borne arthropods, and weeds in California agriculture, particularly in the absence of crop rotation. However, some fumigants have come under increased regulatory scrutiny and are therefore no longer available for use. We tested two biologically based preplant crop-protection fumigant alternatives for their effectiveness in reducing populations of Delia radicum (L.

Association between the transition from unemployment to re-employment after abrupt bankruptcy and the depressive symptoms.

The study aimed to examine the effects of long-term unemployment and the transition from unemployment to re-employment after abrupt bankruptcy on the mental health of unemployed Japanese. The cases of 96 men and 54 women who were laid off by a large shoemaking company because of sudden bankruptcy in 1998, were examined for one year. The mental health of these individuals was evaluated using a 'self-rating questionnaire for depression (SRQ-D)'.

Effect of a physical activity improvement program using the transtheoretical model at a small-scale company.

The present study aimed to investigate the potential use of the transtheoretical model (TTM) by clarifying the program's effects on workers at a small-scale company. Subjects were 22 male workers at a communication system company. They were divided into two physical activity improvement program groups, the TTM-based assistance group (TTM group, n=12) and the control group (n=10).

Effects of short-term exposure to whole-body vibration on wakefulness level.

To investigate the relationships between whole-body vibration and changes in wakefulness, We measured the change of a subjective wakefulness level and electroencephalogram (EEG). Subjects are ten healthy male university students. The subjects were exposed to whole-body vibration with frequency (10 Hz) and acceleration level (0.

Sequence-based typing identifies a novel HLA-DPB1 allele, DPB1*9601.

In this report we describe the identification of a novel HLA-DPB1 allele, DPB1*9601, found in a Caucasian individual sample named ucla#356. The new allele was detected in the DNA of ucla#356 during routine HLA sequence-based typing (SBT) of samples participating in the UCLA International HLA DNA Exchange (number 55) for HLA DNA Proficiency Testing. DPB1*9601 was identical to DPB1*3901 except for a single nucleotide substitution 'G'-->'C' in previously constant position 277 (position 177, respectively, counting only exon 2).

Heparin adheres to the damaged arterial wall and inhibits its thrombogenicity.

Heparin binds to thrombogenic extracellular matrices as well as to smooth muscle cells of the vascular wall in vitro. The inhibitory effects of heparin on thrombogenicity of the damaged arterial wall were examined in vivo using small mesenteric arteries of rats and a video recording system attached to a microscope. To induce thrombosis, we damaged the vessel wall over a short segment by compression and exposed the media to the blood stream.

Effect of an antiarrhythmic agent, carocainide, on action potentials of ventricular papillary muscle of the guinea-pig heart in vitro.

The effect of carocainide, a new benzofuran derivative showing an antiarrhythmic action in animal models, on transmembrane potentials was examined in isolated ventricular papillary muscles of guinea-pig, using a conventional microelectrode technique in vitro. Carocainide, at concentrations above 5 x 10(-6) M, induced a dose-dependent decrease of the maximum upstroke velocity at a stimulation frequency of 0.1 Hz, while the resting membrane potential, the amplitude and duration of action potential were not affected even at 5 x 10(-5) M.