Identification of domperidone metabolites in plasma and urine of gastroparesis patients with LC-ESI-MS/MS.

Domperidone is a prokinetic agent used to treat gastroparesis. Previous studies reported oxidative metabolites of domperidone, detected by radiometric high-performance liquid chromatography or single quadrupole mass spectrometric techniques. Our aim was to identify domperidone Phase I and Phase II metabolites using liquid chromatography combined with electrospray ionization-enabled tandem mass spectrometry.

Clinical response and side effects of metoclopramide: associations with clinical, demographic, and pharmacogenetic parameters.

Objectives: Metoclopramide is associated with variable efficacy and side effects when used in the treatment of gastroparesis.

Aim: To determine associations of clinical and pharmacogenetic parameters with response and side effects to metoclopramide in patients with upper gastrointestinal symptoms suggestive of gastroparesis.

Methods: Gastroparetic patients treated with metoclopramide were enrolled.

Fatigue: a prevalent symptom in gastroparesis.

Background: Fatigue is seen in many medical conditions. Patients with gastroparesis may complain of fatigue.

Aim: The aim of this work is to first assess the prevalence and severity of fatigue in patients with gastroparesis, and secondly to correlate fatigue with symptoms, quality of life, and factors that may contribute to fatigue.

Gastric emptying scintigraphy: is four hours necessary?

Introduction: Recommendations for gastric emptying scintigraphy (GES) suggest imaging over 4 hours to better define gastroparesis.

Aims: To determine the value of defining delayed gastric emptying at time points earlier than 4 hours.

Methods: GES was performed with ingestion of a liquid egg white meal with imaging at 0, 0.

Gastric emptying of solids and liquids for evaluation for gastroparesis.

Background: Gastric emptying scintigraphy (GES) of solids is typically used to evaluate for gastroparesis.

Aims: The purpose of this study was to determine the value of simultaneously measuring gastric emptying of liquids and solids for assessing patients for delayed gastric emptying.

Methods: A total of 596 patients at our institution from September 2007 to January 2010 underwent GES with assessment of both solid and liquid gastric emptying.

Acute liver failure.

Acute liver failure is a rare but often catastrophic illness affecting the liver and multiple organ systems. Patients with acute liver failure require a multidisciplinary approach for adequate management. With improved critical care and the availability of liver transplantation, survival has significantly improved.