Publications by authors named "Munyangaju I"
Introduction: Cardiovascular diseases contribute significantly to global morbidity and mortality. MicroRNAs are crucial in the development and progression of these diseases by regulating gene expression in various cells and tissues. Their roles in conditions like atherosclerosis, heart failure, myocardial infarction, and arrhythmias have been widely researched.
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- Sleep disorders are common and linked to various health issues, increasing the risk of inflammatory, metabolic, and cardiovascular diseases through different mechanisms.
- The authors reviewed research up to June 2023, examining the connections between sleep disorders and cardiovascular diseases, including their diagnosis and treatment options.
- Key findings indicate that sleep disorders impact heart rate variability, hypertension, and obesity, ultimately affecting cardiovascular health, and highlight the need for more studies to understand these relationships and improve treatment approaches.
Introduction: Approximately 50 million people worldwide have epilepsy, with many not achieving seizure freedom. Organ-on-chip technology, which mimics organ-level physiology, could revolutionize drug development for epilepsy by replacing animal models in preclinical studies. The authors' goal is to determine if customized micro-physiological systems can lead to tailored drug treatments for epileptic patients.
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- Tuberculosis is a major global health issue, with children representing a significant proportion of cases and deaths, making early diagnosis challenging, especially in resource-limited settings.
- A multicenter study across Mozambique, South Africa, and Spain will assess the availability of imaging resources and radiation exposure for pediatric TB diagnosis, utilizing retrospective data and standardized surveys among clinicians and radiology staff.
- Data collected will include national inventories of imaging units, survey results on diagnostic practices, and analyses of radiation doses for children under 16, aiming to improve diagnosis and safety in pediatric TB management.
Malaria remains a major public health concern worldwide. Malaria is endemic in Mozambique, with seasonal fluctuations throughout the country. Although the number of malaria cases in Mozambique have dropped by 11% from 2020 to 2021, there are still hotspots in the country with persistent high incidence and low insecticide-treated bed net usage.
View Article and Find Full Text PDFBackground: Mozambique has high rates of cervical cancer and cancer-related deaths among women. A high rate of refusal and low acceptance of treatment is observed among cervical cancer patients. The extent of their knowledge of the disease is unknown.
View Article and Find Full Text PDFIn resource-limited settings, point-of-care ultrasound (POCUS) has great potential to support the timely diagnosis of extrapulmonary tuberculosis (EPTB). We aim to determine the in-hospital mortality due to EPTB according to clinical and POCUS features and risk factors in newly diagnosed patients hospitalized for EPTB in Chókwè district, Mozambique. We analyzed routinely collected data from paper medical files and electronic POCUS records of EPTB in infected patients aged 15 years or older and admitted to Carmelo Hospital of Chókwè from 2016 to 2020.
View Article and Find Full Text PDFBackground: Tuberculosis (TB) is a serious public health problem and remains one of the leading causes of death from an infectious agent globally. Mozambique is one of 30 countries considered to have a high TB burden.
Objectives: To describe the clinical characteristics of TB in children and adults in Bilene District in Gaza Province, Mozambique, over 43 months and to assess determinants of unfavourable treatment outcomes.
Background: Mother-to-child transmission of HIV infection is a significant problem in Mozambique. This study aims to determine the risk factors associated with mother-to-child transmission of HIV in rural Mozambique.
Methods: Retrospective case-control study in a rural area of Bilene District, on the coast of southern Mozambique, performed from January 2017 to June 2018.
HIV remains a major cause of morbidity and mortality for people living in many low-income countries. With an HIV prevalence of 12.4% among people aged over 15 years, Mozambique was ranked in 2019 as one of eight countries with the highest HIV rates in the world.
View Article and Find Full Text PDFIntroduction: Mozambique is one of the poorest nations in the world and its health budget is heavily dependent on external funding. Increasingly, donors prefer to direct their funds through international non-governmental organizations instead of direct donations to the State budget. In the current climate of increased emphasis on health system strengthening, a strong and stable partnership between government and international non-governmental organizations is pivotal for health system strengthening in Mozambique.
View Article and Find Full Text PDFBackground: Tuberculosis (TB) and malnutrition are important causes of morbidity and mortality in children in the developing world.
Aims: To assess the prevalence of pulmonary TB in severely malnourished children and evaluate TB detection using the urine lipoarabinomannan antigen assay (TB-LAM).
Methods: A retrospective analysis was conducted in all pediatric inpatients with severe acute malnutrition at a rural health center in Mozambique, from February to August 2018.