Mixed-methods process evaluation of a proactive approach to healthcare in Parkinson's disease-ParkProReakt: a protocol of a hybrid efficacy-implementation study.

Introduction: People with Parkinson's disease (PwPD) experience a wide range of motor and non-motor symptoms that have a significant impact on their health and quality of life. Effective care management for PwPD involves monitoring symptoms at home, involving specialised multidisciplinary care providers and enhancing self-management skills. This study protocol describes the process evaluation within a randomised clinical trial to assess the implementation and its impact on patient health outcomes of ParkProReakt-a proactive, multidisciplinary, digitally supported care model for community-dwelling PwPD.

Do sensorimotor insoles improve gait safety in patients with Parkinson's disease on a short scale?

Introduction: Parkinson's disease (PD) often leads to gait abnormalities, increasing the risk of falls and affecting daily life. Sensorimotor insoles aim to enhance foot sensitivity, potentially improving gait stability.

Methods: This study examined whether there are short-term effects of sensorimotor insoles on neural activation (measured by EEG), kinematic gait parameters (speed, cadence, step length, and step-length variability), and subjective gait stability in PD patients.

Priorities in healthcare provision in Parkinson's disease from the perspective of Parkinson Nurses: A focus group study.

Background: Through their expertise and diverse skills, Parkinson Nurses are key care providers for people with Parkinson's disease. They are seen as an important profession for person-centered and multidisciplinary care, considered priorities in Parkinson's care delivery. Currently, however, little is known about the priorities that this profession itself defines for the care of Parkinson's patients and how they perceive their own role in the care process.

Vascular streak dieback: A novel threat to redbud and other woody ornamental production in the United States.

Eastern redbud ( L.) is a popular and high-value woody ornamental plant native to the eastern and south-central United States of America (U.S.

A unified European hydrogen infrastructure planning to support the rapid scale-up of hydrogen production.

Hydrogen will become a key player in transitioning toward a net-zero energy system. However, a clear pathway toward a unified European hydrogen infrastructure to support the rapid scale-up of hydrogen production is still under discussion. This study explores plausible pathways using a fully sector-coupled energy system model.

The Quality in Quality of Life in Parkinson's Disease: A Qualitative Meta-Synthesis.

Background: Quality of life (QoL) is known to be impaired in people with Parkinson's disease (PwPD). Not surprisingly, a considerable effort of health interventions is aimed at maintaining or improving QoL. Yet, little is known about its determinants from a PwPD perspective to inform person-centered health care interventions.

Advancing SSP-aligned scenarios of shipping toward 2050.

Developing comprehensive scenarios for the shipping sector has been a challenge for the Integrated Assessment Model (IAMs) community, influencing how attainable decarbonization is in the sector, and for Earth System Models (ESMs), impacting the climate contribution of shipping emissions. Here we present an approach to develop spatially explicit energy demand projections for shipping in alignment with the Shared Socioeconomic Pathways framework and IAMs projections of global fossil fuel demand. Our results show that shipping could require between 14 and 20 EJ by 2050, corresponding to a 3% and 44% increase from 2018 for the SSP1-1.

Hand hygiene compliance in nursing home wards: the effect of increased accessibility of alcohol-based hand rub.

Background: Elderly nursing home residents are vulnerable to infection from micro-organisms. Hand hygiene is considered one of the most important measures to prevent transmission.

Aim: To determine the effect of increased accessibility to alcohol-based hand rub (ABHR) in nursing home wards by monitoring hand hygiene compliance (HHC) among healthcare workers (HCWs).

Safety perception in patients with advanced idiopathic Parkinson's disease - a qualitative study.

Background: A fundamental cornerstone of quality of healthcare is patient safety, which many people with life-limiting illnesses feel is being compromised. Perceptions of impaired safety are associated with the occurrence of psychological distress and healthcare utilization. However, little is known about how people with idiopathic Parkinson's disease (iPD) perceive their own safety toward the end of life.

Randomizing a clinical trial in neuro-degenerative disease.

The paper studies randomization rules for a sequential two-treatment, two-site clinical trial in Parkinson's disease. An important feature is that we have values of responses and five potential prognostic factors from a sample of 144 patients similar to those to be enrolled in the trial. Analysis of this sample provides a model for trial analysis.

Impact of the COVID-19 pandemic on perceived access and quality of care in German people with parkinsonism.

Due to the heterogeneous clinical presentation, people with Parkinsonism (PwP) develop individual healthcare needs as their disease progresses. However, because of limited health resources during the COVID-19 pandemic, many patients were put at risk of inadequate care. All this occurred in the context of inequitable healthcare provision within societies, especially for such vulnerable populations.

Effect of preparation size on the removal of accumulated hard-tissue debris from the mesial root canal system of mandibular molars using SWEEPS technology.

Objectives: This study assessed the influence of preparation size on the efficacy of shock wave-enhanced emission photoacoustic streaming (SWEEPS) and conventional irrigation (CI) on removal of accumulated hard tissue debris (AHTD) from isthmus-containing mandibular molars using micro-computed tomographic analysis.

Materials And Methods: Sixty extracted mandibular molars with two mesial canals connected by an isthmus were selected. Canals were shaped with Mtwo instruments (VDW, Munich, Germany) up to sizes 25/.

Requirements for a maritime transition in line with the Paris Agreement.

The shipping industry is a hard-to-abate sector in today's society. Although past studies have looked at levels of carbon pricing, fuel savings, and the upscaling of green fuel availability separately, we combine these critical parameters for a green transition of the shipping industry to show what it takes to reach sectoral emissions reduction targets in line with the Paris Agreement. We utilize a least-cost optimization model drawing on data on, e.

Automated measurement of malaria parasitaemia among asymptomatic blood donors in Malawi using the Sysmex XN-31 analyser: could such data be used to complement national malaria surveillance in real time?

Background: The recent worldwide increase in malaria cases highlights the need for renewed efforts to eliminate malaria. The World Health Organization advocates that malaria surveillance becomes a core intervention. Current methods to estimate the malaria burden rely on clinical malaria case reports and surveys of asymptomatic parasite infection mainly from children  < 5 years.

Telemedicine as an Untapped Opportunity for Parkinson's Nurses Training in Personalized Care Approaches.

(1) Background: Parkinson nurses (PN) take over important functions in the telemedical care of person's with Parkinson's disease (PwPs). This requires special competencies that have so far been largely unexplored. The aim of the article is to identify competencies of PN operating in a personalized care model.

The Role of Parkinson Nurses for Personalizing Care in Parkinson's Disease: A Systematic Review and Meta-Analysis.

Background: Quality of life (QoL) of persons with Parkinson's disease (PD) is diminished by (non-)motor symptoms, that require personalized care. Parkinson Nurses (PN) may be pivotal promoting tailored care offerings. This systematic review and meta-analysis investigates PD care models and aims at furnishing current concepts of PN to offer personalized care.

Coping Styles in Patients with Parkinson's Disease: Consideration in the Co-Designing of Integrated Care Concepts.

Integrated care models may help in designing care for Parkinson's disease (PD) that is more efficient and patient-centered. However, in order to implement such models successfully, it is important to design these models around patients' needs and preferences. Personality traits and coping styles play a well-studied important role in patients' disease perception and their utilization of medical and social services to cope with their disease.

Measuring Quality of Life in Parkinson's Disease-A Call to Rethink Conceptualizations and Assessments.

Parkinson's disease (PD) is a chronic condition that considerably impacts the perception of quality of life (QoL) in both patients and their caregivers. Modern therapeutic approaches and social efforts strive at maintaining and promoting QoL. It has emerged as a fundamental parameter for clinical follow-up and poses one of the most important endpoints in scientific and economic evaluations of new care models.

A method comparison study of the high throughput automated HISCL® SARS-CoV-2 antigen assay using nasopharyngeal swab samples from symptomatic and asymptomatic subjects against conventional RT-PCR.

Our study aim was to evaluate the performance of the automated Sysmex HISCL® severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigen assay against reverse-transcription polymerase chain reaction (RT-PCR). We tested 277 remnant frozen nasopharyngeal swab samples, stored in universal transport medium (UTM), yielding a sensitivity of 94.9% against historical RT-PCR results with cycle threshold (C ) < 30, and a sensitivity of 76.

Surgical margins in the resection of oral squamous cell carcinoma under local versus general anesthesia.

Objectives: This study analyzes the influence of the surgical setting, i.e. resection under local anesthesia versus resection under general anesthesia, on surgical margins in tumor resection of stage I and II oral squamous cell carcinoma (OSCC).

Deriving Implications for Care Delivery in Parkinson's Disease by Co-Diagnosing Caregivers as Invisible Patients.

For persons with Parkinson's disease, the loss of autonomy in daily life leads to a high level of dependency on relatives' support. Such dependency strongly correlates with high levels of perceived stress and psychosocial burden in informal caregivers. Global developments, such as demographic change and the associated thinning infrastructure in rural areas cause a continuously growing need for medical and nursing care.

Water deficit changes the relationships between epidemiological traits of Cauliflower mosaic virus across diverse Arabidopsis thaliana accessions.

Changes in plant abiotic environments may alter plant virus epidemiological traits, but how such changes actually affect their quantitative relationships is poorly understood. Here, we investigated the effects of water deficit on Cauliflower mosaic virus (CaMV) traits (virulence, accumulation, and vectored-transmission rate) in 24 natural Arabidopsis thaliana accessions grown under strictly controlled environmental conditions. CaMV virulence increased significantly in response to water deficit during vegetative growth in all A.