Solar energy resource availability under extreme and historical wildfire smoke conditions.

By 2050, the U.S. plans to increase solar energy from 3% to 45% of the nation's electricity generation.

BreVamiR3': A comprehensive database for breast cancer-associated genetic variations in miRNA and 3' UTR of their target genes.

Breast cancer (BC) is a multifactorial disease where microRNA (miRNA)-mediated dysregulated gene expression plays a pivotal role in tumorigenesis, progression, and clinical outcomes. Genetic variation, particularly SNPs in miRNA sequences and the 3' untranslated regions (3'UTRs) of their target genes, can disrupt miRNA-mRNA interactions, leading to altered gene expression. Despite several existing databases providing insights into various aspects of miRNAs and their target genes in association with the development of the disease.

MicroRNA signatures in neuroplasticity, neuroinflammation and neurotransmission in association with depression.

Depression is a multifactorial disorder that occurs mainly on account of the dysregulation of neuroplasticity, neurotransmission and neuroinflammation in the brain. In addition to environmental /lifestyle factors, the pathogenesis of disease has been associated with genetic and epigenetic factors that affect the reprogramming of normal brain function. MicroRNA (miRNAs), a type of non-coding RNAs, are emerging as significant players that play a vital role in the regulation of gene expression and have been extensively explored in neurodegenerative disorders.

Detecting Unusual Repetitive Patterns of Behavior Indicative of a Loop-Based Attack in IoT.

Given the high risk of Internet of Things (IoT) device compromise, it is crucial to discuss the attack detection aspect. However, due to the physical limitations of IoT, such as battery life and sensing and processing power, the widely used detection techniques, such as signature-based or anomaly-based detection, are quite ineffective. This research extracted loop-based cases from the transmission session dataset of "CTU-IoT-Malware-Capture-7-1" ("Linux, Mirai") and implemented a loop-based detection machine learning approach.

Novel amino-functionalized MOF-based sensor for zinc ion detection in water and blood serum samples.

Aquatic systems with low zinc levels can experience a significant decrease in carbon dioxide uptake and limited growth of phytoplankton species. In this study, we describe the use of a new fluorescent sensor based on NH-MIL-53(Al), and modified with glutaraldehyde and sulfadoxine, for selectively detecting zinc ions in water and blood serum samples. Characterization of the synthesized material was performed using X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), Brunauer-Emmett-Teller (BET) surface area analysis, X-ray photoelectron spectroscopy (XPS), and scanning electron microscopy (SEM), confirming successful functionalization and preservation of the MOF structure.

Modification of nickel ferrite nanoparticles by sodium docusate surfactant for superior crystal violet dye removal from aqueous solutions.

In this study, nickel ferrite (NiFeO) nanoparticles were synthesized using the Pechini sol-gel method and modified with sodium docusate surfactant. The modified nanoparticles showed an enhanced adsorption capacity of 384.62 mg/g for crystal violet dye, compared to 237.

An Analysis of Radiotherapy Machine Requirements in India: Impact of the Pandemic and Regional Disparities.

Aim: This article examines India's present radiotherapy (RT) machine status and requirements, geographical distribution, and infrastructure need in six regional areas, which include 31 member states and union territories (UTs). It also considers the influence of the COVID-19 pandemic on India's teletherapy sector.

Materials And Methods: Data from reliable resources, including Atomic Energy Regulatory Board, Global Cancer Observatory, and Directory of Radiotherapy Centres databases, were used to analyze the current status of RT machine (RTM) density, regional disparity, and COVID-19 impact on infrastructure growth-rate.

Delayed Diagnosis of Inborn Errors of Immunity Due to CISH Gene Mutation Presenting As Recurrent Tuberculosis.

Tuberculosis (TB) is an infectious disease that most often affects the lungs but can be extrapulmonary, with TB lymphadenitis being the most common extrapulmonary site. The case presented here describes a 54-year-old female patient who was treated for pulmonary TB 20 years prior to this presentation, presented this time with fever, bilateral neck swelling, and unintentional weight loss of 20 kg over four months and histopathological findings of caseating granuloma of the biopsy taken from the right cervical lymph node. After investigation by the immunology team, a genetic test was done.

Titania nanotubes modified with copper enhance osteogenic differentiation of adipose derived stem cells.

To achieve long term success of orthopedic implants, it is critical to have a successful integration of bone and implant material. To accomplish this, various surface modifications have been investigated in research. Even though titania nanotubes and copper have individually demonstrated successful stem cell adhesion, proliferation and differentiation, these modifications have not yet been investigated together.

Arthroscopic Management of Complex Knee Pathologies in a 45-Year-Old Male: A Case Report.

Knee disorders can present in various forms, often involving complex pathologies. The diagnosis and management of these conditions can be challenging, particularly in the absence of associated trauma. A 45-year-old male with a history of chronic right knee pain and clicking presented after failure of conservative treatment modalities.

Analyzing Global Cancer Control: Progress of National Cancer Control Programs through Composite Indicators and Regression Modeling.

Aim: Cancer is a significant public health concern, and National Cancer Control Programs (NCCPs) are crucial for reducing its burden. However, assessing the progress of NCCPs is challenging due to the complexity of cancer control outcomes and the various factors that influence them. Composite indicators can provide a comprehensive and accurate assessment of NCCP progress.

Child maltreatment and peer relationship quality: Types and timing of maltreatment and gender differences.

Introduction: Research demonstrates that child maltreatment can negatively impact adolescent peer relationships. It is not well understood, however, how the type of maltreatment and its timing (when it occurs) affects the dimensions of peer relationship quality (i.e.

Awareness and Attitudes Among Parents of Females Aged 9-26 in Saudi Arabia Regarding Human Papillomavirus Vaccination.

Background Most cases of cervical cancer are caused by the human papillomavirus (HPV) infection, which can be prevented by vaccination. The HPV vaccine received approval in Saudi Arabia in 2010. Objectives This study aimed to examine the awareness and attitudes toward the HPV vaccine among parents of females aged 9-26 in Saudi Arabia and explore factors contributing to hesitancy or acceptance.

Evaluating ChatGPT to test its robustness as an interactive information database of radiation oncology and to assess its responses to common queries from radiotherapy patients: A single institution investigation.

Purpose: Commercial vendors have created artificial intelligence (AI) tools for use in all aspects of life and medicine, including radiation oncology. AI innovations will likely disrupt workflows in the field of radiation oncology. However, limited data exist on using AI-based chatbots about the quality of radiation oncology information.

Epigenetic reprogramming of mtDNA and its etiology in mitochondrial diseases.

Mitochondrial functionality and its regulation are tightly controlled through a balanced crosstalk between the nuclear and mitochondrial DNA interactions. Epigenetic signatures like methylation, hydroxymethylation and miRNAs have been reported in mitochondria. In addition, epigenetic signatures encoded by nuclear DNA are also imported to mitochondria and regulate the gene expression dynamics of the mitochondrial genome.

Lysophosphatidylcholine induces oxidative stress and calcium-mediated cell death in human blood platelets.

Platelets are essential component of circulation that plays a major role in hemostasis and thrombosis. During activation and its demise, platelets release platelet-derived microvesicles, with lysophosphatidylcholine (LPC) being a prominent component in their lipid composition. LPC, an oxidized low-density lipoprotein, is involved in cellular metabolism, but its higher level is implicated in pathologies like atherosclerosis, diabetes, and inflammatory disorders.

Exosomes in diagnostic and therapeutic applications of ovarian cancer.

Ovarian cancer accounts for more deaths than any other female reproductive tract cancer. The major reasons for the high mortality rates include delayed diagnoses and drug resistance. Hence, improved diagnostic and therapeutic options for ovarian cancer are a pressing need.

Molecular Insights of Drug Resistance in Epilepsy: Multi-omics Unveil.

Epilepsy is a devastating neurological disorder mainly associated with impaired synchronic discharge that leads to sensory, motor, and psychomotor impairments. Till now, about 30 anti-seizure medications (ASMs) have been approved for the management of epilepsy, yet one-third of individuals still have uncontrollable epilepsy and develop resistance. Drug resistance epilepsy (DRE) is defined as the condition where two ASMs fail to control the seizure in epileptic patients.