Making Space in Geographical Analysis.

In this commentary we reflect on the potential and power of geographical analysis, as a set of methods, theoretical approaches, and perspectives, to increase our understanding of how space and place matter for . We emphasize key aspects of the field, including accessibility, urban change, and spatial interaction and behavior, providing a high-level research agenda that indicates a variety of gaps and routes for future research that will not only lead to more equitable and aware solutions to local and global challenges, but also innovative and novel research methods, concepts, and data. We close with a set of representation and inclusion challenges to our discipline, researchers, and publication outlets.

Effect of the Emory Healthy Kitchen Collaborative on Employee Health Habits and Body Weight: A 12-Month Workplace Wellness Trial.

Introduction: Teaching kitchens are being used to facilitate lifestyle changes with a focus on culinary and nutrition programs to improve health behaviors. Less is known regarding their use as a worksite wellness program and their influence on employees' quality of life, body weight, and adoption of healthy behaviors. We evaluated changes in self-reported healthy behaviors, overall health, and weight during a one-year multidisciplinary teaching kitchen program.

Transcriptomic Response of the Atlantic Surfclam (Spisula solidissima) to Acute Heat Stress.

There is clear evidence that the oceans are warming due to anthropogenic climate change, and the northeastern coast of USA contains some of the fastest warming areas. This warming is projected to continue with serious biological and social ramifications for fisheries and aquaculture. One species particularly vulnerable to warming is the Atlantic surfclam (Spisula solidissima).

Changes in Larval Oyster Swimming Behavior with Salinity and Larval Age.

AbstractEastern oysters () are sessile, relying on a larval phase to disperse in estuaries. Oyster larval swimming behavior can alter dispersal trajectories and patterns of population connectivity. Experiments were conducted to test how both (1) acclimation time to new environmental conditions and (2) larval swimming behavior change with salinity and larval age.

HPV Vaccine Communication Competency Scale for Medical Trainees: Interdisciplinary Development Study.

Background: Human papillomavirus (HPV) infection is the most common sexually transmitted infection in the United States. High-risk HPV strains are associated with cancer of the cervix, oropharynx, anus, rectum, penis, vagina, and vulva. To combat increasing HPV-related cancers, the 9-valent HPV vaccine Gardasil was developed.

Dynamic energy budget modeling of Atlantic surfclam, Spisula solidissima, under future ocean acidification and warming.

A dynamic energy budget (DEB) model integrating pCO was used to describe ocean acidification (OA) effects on Atlantic surfclam, Spisula solidissima, bioenergetics. Effects of elevated pCO on ingestion and somatic maintenance costs were simulated, validated, and adapted in the DEB model based upon growth and biological rates acquired during a 12-week laboratory experiment. Temperature and pCO were projected for the next 100 years following the intergovernmental panel on climate change representative concentration pathways scenarios (2.

Cost Analysis of Developing, Implementing, and Evaluating a Multi-Disciplinary Teaching Kitchen.

Introduction: Teaching kitchens have emerged as strategies to deliver lifestyle medicine principles and practices. However, a better understanding of their implementation, delivery cost, and potential benefits are needed. This article provides a comprehensive analysis of the costs associated with the development, deployment, and evaluation of the Emory Healthy Kitchen Collaborative (EHKC) teaching kitchen clinical trial.

A bibliometric analysis of nursing and midwifery research in the Caribbean.

Purpose: To determine the research output of Caribbean nurses and midwives.

Methods: We searched the Scopus database to identify publications by Caribbean nurses and midwives during the period 2000-2020. Publications were included in the analysis if they had at least one author who was either a nurse or midwife and affiliated with a Caribbean geographic location.

Development of Culinary and Self-Care Programs in Diverse Settings: Theoretical Considerations and Available Evidence.

Culinary-based self-care programs are innovative and increasingly utilized models for catalyzing behavior change and improving health and well-being. The content, duration, and delivery of existing programs vary considerably. Between January and August 2019, we developed a teaching kitchen and self-care curriculum, which was administered as part of a year-long worksite well-being program to employees at an academic healthcare system.

Energetic response of Atlantic surfclam Spisula solidissima to ocean acidification.

In this study, we assessed the Atlantic surfclam (Spisula solidissima) energy budget under different ocean acidification conditions (OA). During 12 weeks, 126 individuals were maintained at three different ρCO concentrations. Every two weeks, individuals were sampled for physiological measurements and scope for growth (SFG).

COVID-19 Brings About Rapid Changes in the Telehealth Landscape.

Telehealth is still an evolving tool with many practitioners noting that barriers such as reimbursement and liability issues exist, preventing its regular use. This commentary addresses the many legislative changes that have taken place during the coronavirus (COVID-19) pandemic. First, we provide a brief overview of changes and describe the impact of these changes on both the current and future physician workforce.

PDCD4 regulates axonal growth by translational repression of neurite growth-related genes and is modulated during nerve injury responses.

Programmed cell death 4 (PDCD4) protein is a tumor suppressor that inhibits translation through the mTOR-dependent initiation factor EIF4A, but its functional role and mRNA targets in neurons remain largely unknown. Our work identified that PDCD4 is highly expressed in axons and dendrites of CNS and PNS neurons. Using loss- and gain-of-function experiments in cortical and dorsal root ganglia primary neurons, we demonstrated the capacity of PDCD4 to negatively control axonal growth.

Morphological Variability Among Broods of First-Stage Blue Crab (Callinectes sapidus) Zoeae.

External morphology has been shown to influence predation and locomotion of decapod larvae and is, therefore, directly related to their ability to survive and disperse. The first goal of this study was to characterize first-stage blue crab zoeal morphology and its variability across larval broods to test whether inter-brood differences in morphology exist. The second was to identify possible correlations between maternal characteristics and zoeal morphology.

Examination of the potential relationship between boring sponges and pea crabs and their effects on eastern oyster condition.

The eastern oyster Crassostrea virginica provides a number of ecosystem services and is an important commercial fishery species along the US East and Gulf Coasts. Oyster populations have declined dramatically due to overharvesting, habitat loss, and disease. As restoration efforts and aquaculture of oysters continue to increase throughout their range, it is important to consider the impacts of a number of potential oyster pests, including the boring sponge Cliona spp.

Combined symptom index and second-generation multivariate biomarker test for prediction of ovarian cancer in patients with an adnexal mass.

Objective: To assess the performance of a symptom index (SI) and multivariate biomarker panel in the identification of ovarian cancer in women presenting for surgery with an adnexal mass.

Study Design: Prospective study of patients seen at a tertiary medical center. Following consent, patients completed an SI and preoperative serum was collected for individual markers (CA 125) and a second-generation FDA-cleared biomarker test (MIA2G).

Adherence to practice guidelines is associated with reduced referral times for patients with ovarian cancer.

Background: Patients with ovarian cancer tend to receive the highest quality of care at high-volume cancer centers with gynecological oncologists. However, the care that they receive prior to gynecological oncology consult has not been examined. We investigated the quantity and quality of care given to patients with ovarian cancer before being seen by a gynecological oncologist.

Which HIV-infected adults with high CD4 T-cell counts benefit most from immediate initiation of antiretroviral therapy? A post-hoc subgroup analysis of the START trial.

Background: Immediate initiation of antiretroviral therapy (ART) in asymptomatic adults with CD4 counts higher than 500 cells per μL, as recommended, might not always be possible in resource-limited settings. We aimed to identify subgroups of individuals who would benefit most from immediate treatment.

Methods: The START trial was a randomised controlled trial in asymptomatic, HIV-positive adults previously untreated with ART.

Novel near-diploid ovarian cancer cell line derived from a highly aneuploid metastatic ovarian tumor.

A new ovarian near-diploid cell line, OVDM1, was derived from a highly aneuploid serous ovarian metastatic adenocarcinoma. A metastatic tumor was obtained from a 47-year-old Ashkenazi Jewish patient three years after the first surgery removed the primary tumor, both ovaries, and the remaining reproductive organs. OVDM1 was characterized by cell morphology, genotyping, tumorigenic assay, mycoplasma testing, spectral karyotyping (SKY), and molecular profiling of the whole genome by aCGH and gene expression microarray.

A randomized trial comparing concise and standard consent forms in the START trial.

Background: Improving the effectiveness and efficiency of research informed consent is a high priority. Some express concern about longer, more complex, written consent forms creating barriers to participant understanding. A recent meta-analysis concluded that randomized comparisons were needed.

Dysregulation of mitotic machinery genes precedes genome instability during spontaneous pre-malignant transformation of mouse ovarian surface epithelial cells.

Background: Based in epidemiological evidence, repetitive ovulation has been proposed to play a role in the origin of ovarian cancer by inducing an aberrant wound rupture-repair process of the ovarian surface epithelium (OSE). Accordingly, long term cultures of isolated OSE cells undergo in vitro spontaneous transformation thus developing tumorigenic capacity upon extensive subcultivation. In this work, C57BL/6 mouse OSE (MOSE) cells were cultured up to passage 28 and their RNA and DNA copy number profiles obtained at passages 2, 5, 7, 10, 14, 18, 23, 25 and 28 by means of DNA microarrays.

Identification of bacterial pathogens and antimicrobial resistance directly from clinical urines by nanopore-based metagenomic sequencing.

Objectives: The introduction of metagenomic sequencing to diagnostic microbiology has been hampered by slowness, cost and complexity. We explored whether MinION nanopore sequencing could accelerate diagnosis and resistance profiling, using complicated urinary tract infections as an exemplar.

Methods: Bacterial DNA was enriched from clinical urines (n = 10) and from healthy urines 'spiked' with multiresistant Escherichia coli (n = 5), then sequenced by MinION.

Clinical handover practices in maternity services in Ireland: A qualitative descriptive study.

Objective: the objective was to examine and describe clinical handover practices in Irish maternity services.

Design: the study design incorporated interviews and focus group discussions with a purposive sample of healthcare practitioners working in Irish maternity services.

Setting: five maternity hospitals and fourteen co-located maternity units.