Effectiveness of three mouth rinsing agents against mutans and species - A comparative study.

Background: Dental caries is one of the most common chronic childhood diseases and is a cause of continuous discomfort through impaired function and esthetics. To control dental caries, the removal of plaque is of utmost importance, and that further necessitates the use of chemotherapeutic agents. Several side effects associated with chlorhexidine have stimulated the search for an alternative chemotherapeutic agent.

Investigation and comparison of the effects of two probiotic bacteria, and in reducing mutans streptococci levels in the saliva of children.

Background: Probiotic organisms Lactobacillus reuteri UBLRU-87 and Bifidobacterium bifidum UBBB-55 were proven to be acting against the caries causing organisms.

Aims: This study aims to evaluate the influence of Lactobacillusreuteri, Bifidobacterium bifidum and their blend on Mutans streptococci count in the saliva of children, and also to appraise the sustainability of their action.

Materials And Methods: A randomized, double-blind and placebo-controlled study with 60 subjects (15 in each group) in 6-14 years of age group.

Computational and theoretical exploration for clinical suitability of Remdesivir drug to SARS-CoV-2.

A methodology for the exploration of clinical suitability of Remdesivir drug to SARS-CoV-2 main protease based on the computational, theoretical analysis pertinent to Gibb's free energy computed from the Molecular Dynamic simulations with OPLS-AA force field at 300 K/atmospheric pressure and the variation of thermodynamic potentials over the entire simulation run of 100 ns. This study emphasized the suitability of Remdesivir drug to SARS-CoV-2 protein and the same is emphasized by the results of global clinical trials. This methodology can be applied for future design, development of more specific repurposed inhibitors for the treatment of SARS-CoV-2 infection.

Evaluation of Serum C-reactive Protein Levels in Subjects with Aggressive and Chronic Periodontitis in Comparison with Healthy Controls: A Clinico-biochemical Study.

Aim: Evaluation and comparison of serum C-reactive protein (CRP) levels in subjects with chronic and aggressive periodontitis.

Materials And Methods: Based on the periodontal status, 45 subjects were selected and divided into three groups. Group I - subjects with clinically healthy periodontium, Group II - generalized aggressive periodontitis (GAP), and Group III - chronic periodontitis (CP).