Cationic Peptidomimetic Amphiphiles Having a -Aryl- or -Naphthyl-1,2,3-Triazole Core Structure Targeting () : Synthesis, Antibacterial Evaluation, and an In Vivo Infection Model.

(also known as ) is a Gram-positive anaerobic, spore producing bacterial pathogen that causes severe gastrointestinal infection in humans. The current chemotherapeutic options are inadequate, expensive, and limited, and thus inexpensive drug treatments for infection (CDI) with improved efficacy and specificity are urgently needed. To improve the solubility of our cationic amphiphilic 1,1'-binaphthylpeptidomimetics developed earlier that showed promise in an in vivo murine CDI model we have synthesized related compounds with an -arytriazole or -naphthyltriazole moiety instead of the 1,1'-biphenyl or 1,1'-binaphthyl moiety.