Gene-centric multi-omics integration with convolutional encoders for cancer drug response prediction.

Motivation: Tumor heterogeneity, including genetic and transcriptomic characteristics, can reduce the efficacy of anticancer pharmacological therapy, resulting in clinical variability in patient response to therapeutic medications. Multi-omics integration can allow in silico models to provide an additional perspective on a biological system.

Methods: In this study, we propose a gene-centric multi-channel (GCMC) architecture to integrate multi-omics for predicting cancer drug response.

A novel approach to predicting the synergy of anti-cancer drug combinations using document-based feature extraction.

Background: To reduce drug side effects and enhance their therapeutic effect compared with single drugs, drug combination research, combining two or more drugs, is highly important. Conducting in-vivo and in-vitro experiments on a vast number of drug combinations incurs astronomical time and cost. To reduce the number of combinations, researchers classify whether drug combinations are synergistic through in-silico methods.

Thermal Dynamics of a Novel Radio-Frequency Device for Endoscopic Spine Surgery: An Experimental Model.

Study Design: Experimental study.

Objective: In this study, the ambient temperature of a radiofrequency (RF) electrode tip was compared and analyzed in terms of products, mode, flow quantity, and flow rate.

Summary Of Background Data: Endoscopic spine surgery is a widely used operation for degenerative lumbar stenosis and herniated lumbar disc.

Effect of Incorporating a Dimethacrylate Monomer on the Shear Bond Strength of Two Adhesive Resin Cements to Zirconia Ceramic.

Self-assembled nano-layering resulting from interaction of the phosphate functional group of adhesive monomers with zirconia ceramic surface has been proposed. The purpose of this study was to investigate the bond strengths of two adhesive resin cements (Panavia F 2.0 and BisCem) containing phosphate monomers added with various concentrations (0.

Formation of Nano/Micro Hierarchical Structures on Titanium Alloy Surface by a Novel Etching Solution.

A new effective oxidative solution for titanium (Ti) surface etching was recently developed. The present study was aimed at determining the influence of shorter (than 240 min) treatment time on the surface characteristics of the Ti nano/micro hierarchical structures. Cylinder-shaped Ti grade 5 alloys were etched for 30, 60, 120, and 240 min at room temperature and cleaned successively with acetone, ethanol, and distilled water in an ultrasonic bath.

Multi-channel PINN: investigating scalable and transferable neural networks for drug discovery.

Analysis of compound-protein interactions (CPIs) has become a crucial prerequisite for drug discovery and drug repositioning. In vitro experiments are commonly used in identifying CPIs, but it is not feasible to discover the molecular and proteomic space only through experimental approaches. Machine learning's advances in predicting CPIs have made significant contributions to drug discovery.

Influence of Different Post-Plasma Treatment Storage Conditions on the Shear Bond Strength of Veneering Porcelain to Zirconia.

This study investigated whether different storage conditions of plasma-treated zirconia specimens affect the shear bond strength of veneering porcelain. Zirconia plates were treated with a non-thermal atmospheric argon plasma (200 W, 600 s). Porcelain veneering (2.

Combined Effect of a Microporous Layer and Type I Collagen Coating on a Biphasic Calcium Phosphate Scaffold for Bone Tissue Engineering.

In this study, type I collagen was coated onto unmodified and modified microporous biphasic calcium phosphate (BCP) scaffolds. Surface characterization using a scanning electron microscope (SEM) and a surface goniometer confirmed the modification of the BCP coating. The quantity of the collagen coating was investigated using Sirius Red staining, and quantitative assessment of the collagen coating showed no significant differences between the two groups.

Improved Resin-Zirconia Bonding by Room Temperature Hydrofluoric Acid Etching.

This study was conducted to evaluate the shear bond strength of "non-self-adhesive" resin to dental zirconia etched with hydrofluoric acid (HF) at room temperature and to compare it to that of air-abraded zirconia. Sintered zirconia plates were air-abraded (control) or etched with 10%, 20%, or 30% HF for either 5 or 30 min. After cleaning, the surfaces were characterized using various analytical techniques.