Publications by authors named "Mungunsarnai Ganbold"
Article Synopsis
- Glioblastoma is an aggressive brain cancer that currently lacks effective treatments, prompting research for better therapeutic options.
- Researchers discovered a compound called gliocidin that selectively kills glioblastoma cells without harming normal cells by targeting a specific vulnerability in the cancer's purine synthesis process.
- Gliocidin works by being converted into an active metabolite that disrupts cancer cell metabolism, and when combined with the drug temozolomide, it shows potential for enhancing patient survival rates in animal models.
Glioblastoma (GBM) is an incurable disease with high intratumoral heterogeneity. Bioinformatic studies have examined transcriptional heterogeneity with differing conclusions. Here, we characterize GBM heterogeneity and highlight critical phenotypic and hierarchical roles for quiescent cancer stem cells (qCSCs).
View Article and Find Full Text PDFWe test the hypothesis that glioblastoma harbors quiescent cancer stem cells that evade anti-proliferative therapies. Functional characterization of spontaneous glioblastomas from genetically engineered mice reveals essential quiescent stem-like cells that can be directly isolated from tumors. A derived quiescent cancer-stem-cell-specific gene expression signature is enriched in pre-formed patient GBM xenograft single-cell clusters that lack proliferative gene expression.
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