Publications by authors named "Munesh Meena"
Background: Mechanical ventilation is essential for managing acute respiratory failure, but traditional methods of assessing oxygenation, like the PaO2/FiO2 ratio, pose challenges due to invasiveness and cost.
Objective: This single-centre prospective observational study aimed to assess the potential of the non-invasive Oxygen Saturation Index (OSI), utilising SpO2 measurements, to diagnose hypoxemia in mechanically ventilated adults. The study sought to establish correlations between OSI, oxygenation index (OI), PaO2/FiO2 ratio and SpO2/FiO2 ratio.
Effect of Urinary Trypsin Inhibitor (Ulinastatin) Therapy in COVID-19.
Indian J Crit Care Med
June 2022
Article Synopsis
- The study investigates the effectiveness of ulinastatin, a urinary trypsin inhibitor, in treating COVID-19 patients who experience end-organ damage linked to inflammatory responses.
- Researchers analyzed data from 736 hospitalized patients over a month, using propensity score matching to compare outcomes between a control group and those receiving ulinastatin.
- The results showed no significant differences in ICU length of stay or in-hospital mortality rates between the two groups, highlighting the need for larger, randomized controlled trials to further assess the potential benefits of ulinastatin therapy in COVID-19 treatment.