Publications by authors named "Muneko Kataoka"
Previous studies have demonstrated the clinical utility of cognitive-behavioral therapy in improving emotion regulation in children on the autism spectrum. However, no studies have elucidated the clinical utility of cognitive-behavioral therapy in improving emotion regulation in autistic adults. The aim of the present pilot study was to explore the preliminary clinical utility of a group-based cognitive-behavioral therapy program designed to address emotion regulation skills in autistic adults.
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- Bipolar disorder is linked to recurrent manic and depressive episodes, and researchers are studying its genetic factors by analyzing ultra-rare mutations in families with this condition.
- The study finds significant mutations in constrained genes and presynaptic active zone genes, suggesting these mutations play a role in the disorder.
- Additionally, both germline (inherited) and postzygotic (acquired after conception) mutations in developmental disorder genes are implicated, supporting the idea that such mutations could increase the risk for bipolar disorder.
Article Synopsis
- The study investigates the impact of rare missense variants in the POLG1 gene on bipolar disorder by using multiple assessment methods, including in silico predictions, in vitro biochemical assays, and clinical evaluations.
- Researchers analyzed variants in 796 Japanese bipolar disorder patients and 767 controls, finding 23 distinct variants to assess.
- Results indicated that deleterious POLG1 variants were significantly more common in patients than in controls, suggesting these variants contribute to the risk of bipolar disorder through mitochondrial dysfunction.