Publications by authors named "Munegowda Koralur"
Article Synopsis
- The study aimed to assess the effectiveness of a multiplex PCR (M-PCR) test for identifying herpes simplex virus types 1 and 2 in genital ulcer disease specimens from public health labs.
- A total of 186 specimen tests were conducted across four public health laboratories, compared to results from the CDC's reference lab, showing a high agreement rate of 94%-100% for herpes detection.
- The M-PCR assay was successful in detecting HSV and found 12 suspected syphilis cases, indicating its potential to enhance diagnostics for genital ulcer infections in state and local health departments.
Orientia tsutsugamushi (Ots) frequently causes severe scrub typhus infections in the Asia-Pacific region. Korean investigators have demonstrated that Ots encodes five different autotransporter domain (ATD) proteins (ScaA-ScaE). ScaA functions as an adhesin and confers protective immunity in a lethal mouse model of Ots infection.
View Article and Find Full Text PDFScrub typhus (ST) is an underdiagnosed acute febrile illness in the Asia Pacific region with recent reemergence. Clinical diagnosis is difficult, and laboratory confirmation is largely based on serological and molecular tests. However, Weil-Felix test still remains the only test available in much of the rural tropics where a disproportionate number of cases occur.
View Article and Find Full Text PDFOrientia tsutsugamushi (Ots) is an obligate, intracellular, mite-transmitted human pathogen which causes scrub typhus. Understanding the diversity of Ots antigens is essential for designing specific diagnostic assays and efficient vaccines. The protective immunodominant type-specific 56 kDa antigen (TSA) of Ots varies locally and across its geographic distribution.
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