Eur J Med Chem
January 2025
The growing prevalence of microbial infections, and antimicrobial resistance (AMR) stemming from the overuse and misuse of antibiotics, call for novel therapeutic agents, particularly ones targeting resistant microbial strains. Scientists are striving to develop innovative agents to tackle the rising microbial infections and abate the risk of AMR. Pyrazole, a five-membered heterocyclic compound belonging to the azole family, is a versatile scaffold and serves as a core structure in many drugs with antimicrobial and other therapeutic effects.
View Article and Find Full Text PDFBackground Acute biliary pancreatitis (ABP), a major inflammatory illness, is primarily caused by gallstone blockage of the common bile duct. The pathophysiology of ABP has been linked to serum triglyceride (TG) levels, suggesting a potential role for TG in predicting disease severity. Objective The research objective was to investigate the association between serum TG levels and the severity of ABP.
View Article and Find Full Text PDFBackground and objective Khyber Pakhtunkhwa is the third largest province of Pakistan by population and has a high incidence of ischemic stroke. We evaluated all patients who presented to the largest tertiary care facility in the province to learn about the current trends in the management of ischemic stroke and explore future opportunities in this regard. Materials and methods This prospective observational research was carried out at the Lady Reading Hospital-Medical Teaching Institute (LRH-MTI), Peshawar, in the province of Khyber Pakhtunkhwa (KP).
View Article and Find Full Text PDFBackground: The association between allergies and cancer is contradictory, whereas some forms of cancer have inverse associations with allergies. Allergic rhinitis (AR) is the most prevalent form of allergy, and lung cancer is one of the most prevalent forms of cancer with the highest mortality rate. Recent studies have reported a positive association between asthma and lung cancer; however, this association is inconclusive.
View Article and Find Full Text PDFAlthough intracranial foreign bodies are typically associated with penetrating injuries or surgical interventions, they can also occur as a result of rare instances of child abuse. Enduring such abuse and neglect as an infant can lead to life-long neurological problems, developmental delays, and impairments. The present case involved a 14-year-old male adolescent who was brought to the emergency room due to recurrent generalized tonic seizures.
View Article and Find Full Text PDFEcotoxicol Environ Saf
January 2021
Nanomaterials (NMs) have significant technological advantages due to their unique properties but their release into the environment also carry potential eco-toxicological risks. CuO NMs have numerous industrial and commercial applications, however less is known about the risks to human health and ecosystems. This study investigated different shapes of nano-CuO (cubic and octahedron) with humic acid (HA: 2 mg/L and 10 mg/L) on the reproduction, growth, survival rate and Cu accumulation in the two-generations of Daphnia Magna species.
View Article and Find Full Text PDFJ Coll Physicians Surg Pak
October 2017
Although infections with fungi, such as Rhizopus species,usually occur in diabetics or immunocompromised patients, they can also rarely affect immunocompetent individuals. We present a case of disseminated infection with multiple cold abscesses in a 13-year, otherwise healthy girl caused by Rhizopus arrhizus.
View Article and Find Full Text PDFJ Ayub Med Coll Abbottabad
December 2017
Background: Antibiotic misuse for upper respiratory tract infections such as the common cold is widespread in clinical practice. Excessive prescription of antibiotics by doctors has resulted in increased antimicrobial resistance. This led to our objective of determining the percentage of doctors in Pakistan prescribing antibiotics for the treatment of common cold and to know about their knowledge in preventing the spread of this disease.
View Article and Find Full Text PDFJ Coll Physicians Surg Pak
May 2016
Hepatitis B virus is causing serious health concerns in countries like Pakistan. In Khyber Pakhtunkhwa province, 0.6 milion people were estimated to be infected with this virus in 2008.
View Article and Find Full Text PDFBackground: Tumours of the spinal cord, spinal meninges and cauda equina are relatively rare and their spectrum has not been studied extensively in Khyber Pakhtun Khawa province. We describe here the cases of spinal tumours treated in our setup over a period of two years.
Methods: This Descriptive Case Series was carried out with of 80 patients operated in our centre from January 2013 to January 2015.