Multifunctional electrospun nanofiber films of polyacrylonitrile and polyvinyl alcohol incorporating rhamnose and therapeutic agents for enhanced healing of infected burn wounds.

Infected burn wounds present significant clinical challenges due to delayed healing and risk of infection, necessitating advanced treatments that offer both antimicrobial and regenerative properties. This study aimed to develop and evaluate multifunctional electrospun nanofiber films incorporating rhamnose (as an angiogenic agent) and therapeutic agents, namely fluticasone, mupirocin, ciprofloxacin, and silver sulfadiazine, for the enhanced healing of infected burn wounds. Nanofibers containing rhamnose, polyacrylonitrile, polyvinyl alcohol and therapeutic agents were fabricated electrospinning.

Development of Poly(vinyl alcohol)-Chitosan Composite Nanofibers for Dual Drug Therapy of Wounds.

Current trends in localized drug delivery are emphasizing the development of dual drug-loaded electrospun nanofibers (NFs) for an improved therapeutic effect on wounds, especially infected skin wounds. The objective of this study was to formulate a new healing therapy for an infected skin wound. To achieve this goal, this study involved the development and characterization of poly(vinyl alcohol) (PVA)/chitosan nanofibers loaded with ciprofloxacin and rutin hydrate.

In Vivo Wound Healing Potential and Molecular Pathways of Amniotic Fluid and Moringa Olifera-Loaded Nanoclay Films.

Cutaneous wounds pose a significant health burden, affecting millions of individuals annually and placing strain on healthcare systems and society. Nanofilm biomaterials have emerged as promising interfaces between materials and biology, offering potential for various biomedical applications. To explore this potential, our study aimed to assess the wound healing efficacy of amniotic fluid and -loaded nanoclay films by using in vivo models.

Development, Characterization, and Burn Wound-Healing Potential of Neomycin-Loaded Clay-Reinforced Nanofibers.

: Skin wounds affect millions of individuals around the world, and their treatment is expensive. : The purpose of this study was to make neomycin-loaded CG/PVA/PAN (NCPP) nanofibers to improve wound healing. : The NCPP nanofibers were characterized by using thermogravimetric analysis (TGA), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy, and X-ray diffraction.