Publications by authors named "Munachiso Ndukwe"
Low-grade endometrial stromal sarcoma (LG-ESS) can present diagnostic challenges, due to its overlapping morphological features with other uterine mesenchymal tumors. Misdiagnosis rates remain significant, and immunohistochemical data for LG-ESS are limited to small series and inconsistent antibody panels. This study aimed to refine the IHC profile of LG-ESS by analyzing a large, molecularly confirmed series of 147 cases using a panel of 24 antibodies, including newer markers like transgelin and smoothelin.
View Article and Find Full Text PDFPurpose: MRI-only adaptive brachytherapy (MRI-ABT) is the state-of-the-art for treating locally advanced cervical cancer (LACC) in combination with concurrent chemoradiotherapy. We aimed to evaluate the pattern of pelvic recurrence after the treatment.
Material And Methods: A total of one hundred LACC patients were treated between January 2017 and December 2023 with concurrent chemoradiotherapy of 45 Gy in 25 fractions ± boost to lymphadenopathy (up to a maximum dose of 60 Gy in 25 fractions) with concurrent weekly cisplatin chemotherapy at the dose of 40 mg/m/week, and MR-ABT.
Article Synopsis
- The study examines the impact of the FIGO-WATOG One World Exchange clinical program on the training of postgraduate obstetrics and gynecology (obgyn) trainees in October 2023 in France.
- Data was collected through a 31-item questionnaire distributed to 51 participants, with a 68.6% response rate, revealing demographics such as age, gender, and training year.
- The majority of participants found the exchange beneficial, with many noting significant differences in medical practices, and believed it would enhance their clinical skills upon returning home.
DNA methylation of selected tumor suppressor genes in endometrial hyperplasia.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub
March 2024
Article Synopsis
- - The study aims to explore DNA methylation patterns in specific gene promoters linked to endometrial hyperplasia, comparing samples from patients with atypical hyperplasia, benign hyperplasia, and normal endometrial tissues.
- - Researchers used a technique called methylation-specific multiplex ligation-dependent probe amplification to analyze 164 tissue samples, uncovering significant differences in DNA methylation levels of genes PTEN, CDH13, and MSH6 among the groups.
- - Findings indicate that increased methylation of CDH13, PTEN, and MSH6 may play a crucial role in the progression of endometrial hyperplasia, particularly in atypical cases.
Objective: Summarizing of treatment options for locally recurrent vulvar cancer in patients after previous complex oncological treatment and presenting a case report from our department.
Methods: Presenting a case report of a patient after previous complex oncological treatment for spinocellular cancer of the vulva who presented with a locally recurrent tumor. The patient was treated with a wide radical local excision of the tumor followed by a posterior thigh flap graft.