A Comprehensive Review of Our Understanding and Challenges of Viral Vaccines against Swine Pathogens.

Pig farming has become a strategically significant and economically important industry across the globe. It is also a potentially vulnerable sector due to challenges posed by transboundary diseases in which viral infections are at the forefront. Among the porcine viral diseases, African swine fever, classical swine fever, foot and mouth disease, porcine reproductive and respiratory syndrome, pseudorabies, swine influenza, and transmissible gastroenteritis are some of the diseases that cause substantial economic losses in the pig industry.

Insights into the recent advances in nano-bioremediation of pesticides from the contaminated soil.

In the present scenario, the uncontrolled and irrational use of pesticides is affecting the environment, agriculture and livelihood worldwide. The excessive application of pesticides for better production of crops and to maintain sufficient food production is leading to cause many serious environmental issues such as soil pollution, water pollution and also affecting the food chain. The efficient management of pesticide use and remediation of pesticide-contaminated soil is one of the most significant challenges to overcome.

Assessment of free radicals and reactive oxygen species milieu in nanoparticles adjuvanted outer membrane proteins vaccine against Salmonella typhi.

In this study, calcium phosphate nanoparticles-based (STCNV) and montanide oil adjuvant vaccine (STOAV) containing outer membrane proteins (Omps) of S. Typhi were evaluated for inducing oxidative stress indicators [reduced glutathione (GSH), lipid peroxidation (LPO), catalase, superoxide dismutase (SOD), and total protein] in the tissues of mice after vaccination. The GSH levels though slightly high in the liver, kidney, and lungs of STCNV group were not significantly different from STOAV and the control group (STC).

Calcium phosphate adjuvanted nanoparticles of outer membrane proteins of Typhi as a candidate for vaccine development against Typhoid fever.

The conventional adjuvants used in vaccines have limitations like induction of an imbalanced Th1 and Th2 immune response. To overcome this limitation, novel adjuvants and newer forms of existing adjuvants like calcium phosphate nanoparticles are being tested. Calcium phosphate adjuvanted outer membrane proteins vaccine may work as an efficient, safe and cost effective vaccine against Typhi.

Vaccination with Typhi recombinant outer membrane protein 28 induces humoral but non-protective immune response in rabbit.

Aim: Typhoid is one of the most important food and water borne disease causing millions of deaths over the world. Presently, there is no cost effective vaccine available in India. The outer-membrane proteins (Omps) of have been exhibited as a potential candidate for development of subunit vaccine against typhoid.