Pharmacokinetic properties and clinical efficacy of once-daily sustained-release naproxen.

The pharmacokinetics and clinical efficacy of a once-daily sustained-release formulation of naproxen (sodium salt) have been compared with those of conventional-release agents. In a single dose pharmacokinetic study, the rate of absorption of the sustained-release preparation was less than that of a conventional-release preparation but the extent of absorption was the same. As is the case with conventional-release naproxen, food decreased the rate but not the extent of absorption of the sustained-release formulation.

Transdermal delivery of nicotine in normal human volunteers: a single dose and multiple dose study.

The absorption of nicotine delivered by a transdermal delivery system (TDS) was investigated in two separate studies, (A) a dose proportionality study and (B) a multiple dose study. In the dose range of 15-60 mg nicotine, the AUC and Cmax values were proportional to the dose. The levels achieved were in the same range as reported in smokers, following absorption from nicotine chewing gum.

A new microsphere-based immunofluorescence assay for antibodies to membrane-associated antigens.

The screening of panels of hybridoma supernatants for specific secreted monoclonal antibodies is often achieved by cellular immunofluorescent staining and flow cytometric analysis. In some circumstances such assays are difficult because the required antigen-bearing cell population is not suitable for use in flow cytometry, has limited cell cycle expression or poor in vitro growth. A method is presented here that provides a solution to these difficulties.

Bochdalek hernia of diaphragm in the adult. Diagnosis by computed tomography.

Two cases of asymptomatic Bochdalek hernia in adults with identical roentgenographic findings are reported. Computed tomography (CT) in each case revealed a round mass with a low attenuation coefficient identical to that of adipose tissue, abutting the thoracic surface of the diaphragm and connecting with the subdiaphragmatic density through a diaphragmatic defect. A case of diaphragmatic lipoma was also presented for demonstration of the CT differentiation between lipoma and hernia of the diaphragm.

Mechanism of dissolution of cholesterol-calcium bilirubinate compressed discs in monooctanoin.

The dissolution of cholesterol monohydrate and calcium bilirubinate (neutral salt) mixtures in monooctanoin was investigated using the static disc method. The intrinsic dissolution rate of calcium bilirubinate was orders of magnitude (approximately 1000 fold) lower than that of cholesterol. Cholesterol release decreased as its weight fraction in the solid decreased.