Publications by authors named "Mullaney C"

The cryptic and aquatic life histories of sea turtles have made them a challenging group to directly observe, leaving significant knowledge gaps regarding social behavior and fine-scale elements of habitat use. Using a custom-designed animal-borne camera, we observed previously undocumented behaviors by green turtles () at a foraging area in San Diego Bay, a highly urbanized ecosystem in California, USA. We deployed a suction-cup-attached pop-off camera (manufactured by Customized Animal Tracking Solutions) on 11 turtles (mean straight carapace length = 84.

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Background: Although prior research has identified multiple risk factors for diabetic ketoacidosis (DKA), clinicians continue to lack clinic-ready models to predict dangerous and costly episodes of DKA. We asked whether we could apply deep learning, specifically the use of a long short-term memory (LSTM) model, to accurately predict the 180-day risk of DKA-related hospitalization for youth with type 1 diabetes (T1D).

Objective: We aimed to describe the development of an LSTM model to predict the 180-day risk of DKA-related hospitalization for youth with T1D.

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  • A study was conducted to explore the relationship between maternal age and the prevalence of congenital heart defects (CHD) in Europe from 1995 to 2015 using data from the EUROCAT network, amidst conflicting evidence on this topic.
  • The research showed that CHD prevalence was higher in both younger mothers (≤24 years) and older mothers (35-44 years) compared to those aged 25-29 years, with specific severe CHD types more commonly seen in younger mothers.
  • The study identified increased prevalence rates for certain CHD subtypes, including double outlet right ventricle and hypoplastic heart syndromes, highlighting varying risks associated with different maternal age groups.
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Amniotic band syndrome (ABS) and limb body wall complex (LBWC) have an overlapping phenotype of multiple congenital anomalies and their etiology is unknown. We aimed to determine the prevalence of ABS and LBWC in Europe from 1980 to 2019 and to describe the spectrum of congenital anomalies. In addition, we investigated maternal age and multiple birth as possible risk factors for the occurrence of ABS and LBWC.

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  • The study analyzes the prevalence of nonsyndromic congenital heart defects (CHDs) in Europe from 2008 to 2015, using data from 25 EUROCAT registries across 14 countries.
  • The total prevalence of CHDs was found to be 57.1 per 10,000 births, with live birth prevalence at 60.2 per 10,000, indicating stability over the study period.
  • Trends varied by region, with Norway and England/Wales showing a decrease in prevalence, while Italy and Croatia saw increases, suggesting not all areas are experiencing the same trends.
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  • Aplasia cutis congenita (ACC) is a rare skin condition present at birth, primarily affecting the scalp, with most knowledge derived from individual case reports and small studies.
  • This study utilized data from a large European network (EUROCAT) to assess the prevalence and trends of ACC across 28 registries in 16 European countries, finding 500 cases from 1998-2017.
  • Results showed an ACC prevalence of 5.10 per 100,000 births, with significant prevalence variation across regions, and many cases (33.8%) were associated with other congenital anomalies, particularly Patau syndrome and limb defects.
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This is a report on the development of the second part of a national undergraduate interprofessional standardized curriculum in chronic disease prevention for healthcare professionals in the Republic of Ireland; . The development processes involved in Part 1, , were described earlier. This report presents an overview of the development of a national self-management support curriculum and barriers and enablers encountered.

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  • Pierre Robin sequence (PRS) is a rare birth defect primarily causing respiratory and feeding challenges, and this study aimed to understand its epidemiology through data collected across Europe from 1998-2017.
  • Out of over 11 million births, 1,294 cases of PRS were identified, resulting in a prevalence rate of 12 per 100,000 births, with isolated cases being more common than those associated with other anomalies.
  • Findings indicated that older maternal age is linked to a higher prevalence of PRS, while survival rates were significantly lower for cases with additional chromosomal or structural anomalies compared to isolated cases, suggesting a need for further research into the factors contributing to PRS.
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  • * A large European case-control study analyzed data from 329 VACTERL cases and over 49,000 control subjects, focusing on maternal factors like age, assisted reproductive techniques (ART), and pre-existing health conditions.
  • * Findings revealed that ART use, pregestational diabetes, and chronic lung diseases significantly increased the risk of VACTERL in children, while having twins did not show a correlation with this condition.
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Background: Public health organisations use public health indicators to guide health policy. Joint analysis of multiple public health indicators can provide a more comprehensive understanding of what they are intended to evaluate.

Objective: To analyse variaitons in the prevalence of congenital anomaly-related perinatal mortality attributable to termination of pregnancy for foetal anomaly (TOPFA) and prenatal diagnosis of congenital anomaly prevalence.

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  • The report outlines the establishment of Ireland's first national undergraduate curriculum for chronic disease prevention, developed collaboratively by all higher education institutions and the Health Service Executive (HSE).
  • The curriculum aims to integrate prevention strategies into the routine care of healthcare professionals through the initiative "Making Every Contact Count," which targets major lifestyle risk factors like tobacco use, alcohol consumption, physical inactivity, and poor diet.
  • The ultimate goal of this initiative is to equip new health professionals with the necessary skills to help patients implement lifestyle changes that promote better health and reduce chronic disease risks.
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Background: The VACTERL (Vertebral anomalies, Anal atresia, Cardiac malformations, Tracheo-Esophageal fistula, Renal anomalies, Limb abnormalities) association is the non-random occurrence of at least three of these congenital anomalies: vertebral, anal, cardiac, tracheo-esophageal, renal, and limb anomalies. Diagnosing VACTERL patients is difficult, as many disorders have multiple features in common with VACTERL. The aims of this study were to clearly outline component features, describe the phenotypic spectrum among the largest group of VACTERL patients thus far reported, and to identify phenotypically similar subtypes.

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  • Dandy-Walker malformation is a rare congenital brain defect that affects the cerebellum and fourth ventricle, and this study aimed to investigate its prevalence and detection in Europe.
  • Researchers analyzed data from 28 registries across 17 countries, finding 734 cases of Dandy-Walker malformation and variants, with a prevalence of 6.79 cases per 100,000 births.
  • The study revealed that about 87.6% of cases were detected prenatally, and more than half of the identified cases resulted in pregnancy terminations due to associated anomalies.
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  • * The prevalence of achondroplasia was found to be 3.72 per 100,000 births, with significant findings that early prenatal detection improved over time (71% in 2011-2015 compared to 36% in 1991-1995).
  • * It was noted that about 10% of cases had major associated congenital anomalies, and older paternal age (fathers over 34) was linked to a higher risk of de novo achondroplasia, while familial cases accounted for approximately
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Objective: To validate the estimates of Global Burden of Disease (GBD) due to congenital anomaly for Europe by comparing infant mortality data collected by EUROCAT registries with the WHO Mortality Database, and by assessing the significance of stillbirths and terminations of pregnancy for fetal anomaly (TOPFA) in the interpretation of infant mortality statistics.

Design, Setting And Outcome Measures: EUROCAT is a network of congenital anomaly registries collecting data on live births, fetal deaths from 20 weeks' gestation and TOPFA. Data from 29 registries in 19 countries were analysed for 2005-2009, and infant mortality (deaths of live births at age <1 year) compared with the WHO Mortality Database.

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A systematic review of the literature was completed by the Evidence-Based Practice Group for the Patient population, Intervention/Issue, Comparison Intervention, Outcomes, Timing (PICOT) question: "Does the use of a peripheral nerve block increase the risk for falls and difficulty ambulation in patients after lower extremity surgery through postoperative day 2?" A search of multiple databases using specified key terms resulted in 258 articles for total knee arthroplasty or total hip arthroplasty. These were reduced to 13 with exclusion criteria and became primary evidence. Numbers Needed to Harm and Numbers Needed to Treat (NNT) were calculated.

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The electric communication signals of weakly electric ghost knifefishes (Gymnotiformes: Apteronotidae) provide a valuable model system for understanding the evolution and physiology of behavior. Apteronotids produce continuous wave-type electric organ discharges (EODs) that are used for electrolocation and communication. The frequency and waveform of EODs, as well as the structure of transient EOD modulations (chirps), vary substantially across species.

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Background: Hypospadias is a common congenital malformation. The prevalence of hypospadias has a large geographical variation, and recent studies have reported both increasing and decreasing temporal trends. It is unclear whether hypospadias prevalence is associated with maternal age.

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  • The study investigates the prevalence and epidemiology of congenital diaphragmatic hernia (CDH) using data from European population-based registers between 1980 and 2009.
  • A total of 3,373 CDH cases were reported, with an overall prevalence of 2.3 per 10,000 births, showing a slight increase over time but no change for isolated cases.
  • Results indicated significant geographical variation in CDH prevalence, with 69.3% survival to one week for total cases and 72.7% for isolated cases, while maternal age had no significant impact on CDH occurrence.
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Previous studies have shown that over 40% of babies with Down syndrome have a major cardiac anomaly and are more likely to have other major congenital anomalies. Since 2000, many countries in Europe have introduced national antenatal screening programs for Down syndrome. This study aimed to determine if the introduction of these screening programs and the subsequent termination of prenatally detected pregnancies were associated with any decline in the prevalence of additional anomalies in babies born with Down syndrome.

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Background: Hirschsprung's disease is a congenital gut motility disorder, characterised by the absence of the enteric ganglion cells along the distal gut. The aim of this study was to describe the epidemiology of Hirschsprung's disease, including additional congenital anomalies, total prevalence, trends, and association with maternal age.

Methods: Cases of Hirschsprung's disease delivered during 1980 to 2009 notified to 31 European Surveillance of Congenital Anomaly registers formed the population-based case-series.

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Objectives: The aim of this study is to describe the prenatal diagnosis and epidemiology of multicystic kidney dysplasia (MCKD).

Methods: The study is based on routinely collected data from a European database of major congenital anomalies including 13 registries with cases born in 1997-2006 and covering 1 458 552 births.

Results: There were 601 MCKD cases giving an overall prevalence of 4.

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Background: Neural tube defects (NTDs) are associated with deficient maternal folic acid peri-conceptionally. In Ireland, there is no mandatory folic acid food fortification, partly due to declining NTD rates in recent years. The aim of this study was to ascertain the incident rate of NTD during the period 2009-11 and describe epidemiologically NTD in Ireland.

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Background: This study describes seasonality of congenital anomalies in Europe to provide a baseline against which to assess the impact of specific time varying exposures such as the H1N1 pandemic influenza, and to provide a comprehensive and recent picture of seasonality and its possible relation to etiologic factors.

Methods: Data on births conceived in 2000 to 2008 were extracted from 20 European Surveillance for Congenital Anomalies population-based congenital anomaly registries in 14 European countries. We performed Poisson regression analysis encompassing sine and cosine terms to investigate seasonality of 65,764 nonchromosomal and 12,682 chromosomal congenital anomalies covering 3.

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