Publications by authors named "Mukti Paudel"

We isolated endophytic strains from the healthy roots, stems, and leaves of to investigate their plant growth-promoting activities in vitro. Subsequently, Indole acetic acid (IAA) was quantified and the gene (responsible for IAA synthesis in fungi) was amplified and sequenced. Finally, a germination assay was performed with seeds of and a plant growth assay with protocorms of to test their plant growth-promoting activities.

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People use mushrooms to treat diabetes mellitus. We studied the antidiabetic potential of four mushrooms using porcine pancreatic α-amylase inhibitory activity and alloxan-induced diabetic mice. Methanolic extracts of all mushrooms were effective in inhibiting α-amylase activity.

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Sm. is an important medicinal plant used to treat a variety of diseases through traditional medicine systems such as Ayurveda, Tibetan traditional medicines, Chinese traditional medicines, and others around the world. The IUCN red list has designated it as "vulnerable" due to a decline in wild population by over-exploitation, habitat degradation, illegal collection for trade and traditional use.

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Article Synopsis
  • - A new method for creating skipped 1,4-dienes is introduced, featuring a combination of boryl and silyl groups using a Pd-catalyzed process that is efficient and environmentally friendly by not requiring phosphine ligands.
  • - The technique effectively pairs various alkynes, including those from bioactive compounds, with allenamides and boron reagents, yielding high-quality products with excellent selectivity.
  • - The underlying mechanism involves a series of steps: first, boron attaches to the allenamide, followed by the addition of the alkyne and then the final step of assembly into the desired skipped 1,4-diene, confirmed by theoretical calculations.
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A formal haloalkynylation of allenamides has been described for the synthesis of highly stereo- and regioselective skipped halo enynes. Exclusive γ-regioselectivity is achieved through the intermediacy of a conjugated -tosyliminium intermediate-direct evidence for the formation of which was validated by NMR and HRMS. Quantum mechanical computations reveal that the reactive intermediate geometry is key to controlling the 1,2- or 1,4-regioselectivity of alkyne interception.

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seed germination and protocorms formation were successfully established in traditionally used . Fresh protocorms (178.34 g - 183.

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Majority of the orchid species are used in the traditional medicines for the treatment of several diseases. They are the sources of polysaccharides, phenanthrenes, bibenzyl derivatives, revesteral, stilbenoids and polyphenol compounds. This study explored the cytotoxic activity of seven wild orchid species and identification of medicinally active compounds.

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Endophytism is one of the widely explored phenomena related to orchids and fungi. Endophytic fungi assist plants by supplementing nutrient acquisition, and synthesis of plant growth regulators. is an epiphytic orchid that has a great diversity of endophytic fungi.

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is an epiphytic orchid found in south Asia including Nepal and China. This orchid species is widely used in traditional Chinese medicine (TCM) for the treatment of cancer, diabetes, cataracts, and fever. The objectives of the present research were to assess the antioxidant and cytotoxic properties of its stem's extracts with the identification of bioactive secondary metabolites.

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Background: The medicinal orchid Dendrobium moniliforme contains water-soluble polysaccharides, phenanthrenes, bibenzyl derivatives, and polyphenol compounds. This study explored the antioxidant and cytotoxic activities of D. moniliforme extracts and detected their bioactive compounds.

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