Publications by authors named "Mukovozov I"
Lichen sclerosus (LS) is a chronic, inflammatory dermatosis most commonly characterized by changes in skin pigmentation and pruritus, with associated dyspareunia and genital architectural changes. There are a variety of complications associated with LS, which further worsen a patient's health-related quality of life. A systematic review was conducted to summarize the literature regarding clinical features of LS, as well as LS-associated complications.
View Article and Find Full Text PDFAcne is a multifactorial disorder of the pilosebaceous unit. Photodynamic therapy (PDT) is an energy-based treatment shown to be safe in acne vulgaris, although the mechanism of action of PDT in acne is incompletely understood. This review summarizes the clinical features of and treatment efficacy in acne patients treated with PDT.
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- Atopic dermatitis is a common, chronic skin condition that causes itchy, red, and scaly patches, affecting around 20% of children and 7-14% of adults, depending on the country.
- The condition arises from a combination of genetic, immune, and environmental factors, leading researchers to discover new treatment options targeting inflammation to alleviate symptoms.
- Current treatments range from standard options like emollients and corticosteroids to newer therapies such as biologics (e.g., dupilumab) and small molecule inhibitors, each with specific mechanisms and varying effectiveness and safety profiles.
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- Xanthoma disseminatum (XD) is a rare skin condition within the group of non-Langerhans histiocytosis, presenting mainly as yellow-to-brown lesions on the face, flexures, trunk, and genital areas, and often associated with systemic issues.
- A comprehensive review of 151 studies revealed a total of 166 cases, predominantly in females with an average diagnosis age of 35.3 years, indicating the condition's extensive extracutaneous manifestations, including those affecting the pituitary gland and oropharynx.
- Despite various treatment options explored, including cladribine, systemic steroids, and others, there are low complete response rates, highlighting the need for further research to improve management strategies for
Acne vulgaris, a prevalent dermatological disorder, frequently affects individuals' self-perception and general psychosocial functioning. The growing demand for home-based light therapy devices prompted a systematic review to assess the efficacy of visible light in acne treatment. Overall, 35 studies were included, representing 1185 cases of acne vulgaris (mean age: 23.
View Article and Find Full Text PDFPsoriasis is a chronic, relapsing inflammatory skin disorder that is associated with substantial physical and psychosocial comorbidity. Although biologic agents have offered transformative therapeutic advantages to those unresponsive to traditional treatments, data from recent literature indicate significant undertreatment of certain populations, highlighting potential barriers to access. This review aims to comprehensively elucidate barriers to biological therapy, addressing a recognized gap in the current literature.
View Article and Find Full Text PDFA Review of Intense Pulsed Light in the Treatment of Ocular Rosacea.
J Cutan Med Surg
September 2024
Introduction: Ocular rosacea is an underdiagnosed form of rosacea that may occur with or without typical cutaneous signs of rosacea. One of the common manifestations is dry eyes. Although the use of intense pulsed light (IPL) in the treatment of rosacea-related dry eyes has been reported, a recent review is lacking.
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- Striae are fine lines on the skin that develop from rapid stretching due to factors like pregnancy and weight changes; this review assesses treatment outcomes for these marks.
- The study analyzed 151 articles focusing on the effectiveness and safety of various treatments, revealing that energy-based devices were the most commonly reported (56% of cases).
- The findings indicated that different striae subtypes respond better to specific treatments, highlighting the need for further research to improve treatment efficacy and predict patient responses.
Rosacea is a common chronic skin disease distributed primarily around the central face. Ocular manifestations of rosacea are poorly studied, and estimates of prevalence vary widely, ranging from 6% to 72% in the rosacea population. Treatment options for ocular rosacea include lid hygiene, topical and oral antibiotics, cyclosporine ophthalmic emulsion, oral vitamin A derivatives, and intense pulsed light; however, a direct comparison of treatment methods for ocular rosacea is lacking.
View Article and Find Full Text PDFThe practice of body piercing has been present in many cultures worldwide for centuries, whether for religious or spiritual reasons or as a form of self-expression. In recent years, body piercings have become increasingly popular in all genders, with the most common sites being the ears, mouth, nose, eyebrows, nipples, navel, and genitals. However, despite the widespread utilization of piercings, a comprehensive literature review of associated complications is lacking.
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- Hand-foot-mouth disease (HFMD) is a common childhood infection, with atypical skin symptoms often linked to coxsackievirus A6 (CVA6), leading to unusual lesions beyond the usual areas.
- A systematic review of 85 studies revealed that most affected children were around 2.4 years old, with typical skin findings including vesicles, papules, and bullae, particularly on arms and face, and identified CVA6 in 63% of cases.
- The atypical presentations can cause misdiagnoses and excessive treatments, highlighting the need for better understanding and awareness of these variations to enhance patient care and infection control guidance.