Influence of intrinsic spin ordering in LaSrCoFeO and BaSrCoFeO towards electrocatalysis of oxygen redox reaction in solid oxide cell.

The redox reaction of oxygen (OER & ORR) forms the rate determining step of important processes like cellular respiration and water splitting. Being a spin relaxed process governed by quantum spin exchange interaction, QSEI (the ground triplet state in O is associated with singlet oxygen in HO/OH), its kinetics is sluggish and requires inclusion of selective catalyst. Functionality and sustainability of solid oxide cell involving fuel cell (FC) and electrolyzer cell (EC) are also controlled by ORR (oxygen redox reaction) and OER (oxygen evolution reaction).

Insights into biomimetic system-ligand interaction of substituted isophthalic acid: A functionality induced photophysical study.

The present article attempts to interpret the modulation of photophysical properties of isophthalic acid (IPA) through its amino [5-amino isophthalic acid (5-amino IPA)] and azido [5-azido isophthalic acid (5-azido IPA)] substituted derivatives which are chemically potent organic ligands. The ground state structure-reactivity correlation of 5-amino IPA and 5-azido IPA has been deciphered through computational studies. The computed energetics show significant interaction feasibility of the substituted ligand systems with the biomimetic systems which is further validated experimentally.

Advancing Electrode Properties through Functionalization for Solid Oxide Cells Application: A Review.

Hydrogen energy has emerged as the only renewable which is capable of sustaining the prevalent energy crisis in conjunction with other intermittent sources. In this connection, solid oxide cell (SOC) is the most sustainable solid-state devices capable of recycling and reproducing green hydrogen fuel. It is operable in reversible modes viz, fuel cell (FC) and electrolysis cell (EC).

Supramolecular Arrangement and DFT analysis of Zinc(II) Schiff Bases: An Insight towards the Influence of Compartmental Ligands on Binding Interaction with Protein.

We report, for the first time, a detailed crystallographic study of the supramolecular arrangement for a set of zinc(II) Schiff base complexes containing the ligand 2,6-bis((E)-((2-(dimethylamino)ethyl)imino)methyl)-4-R-phenol], where R=methyl/tert-butyl/chloro. The supramolecular study acts as a pre-screening tool for selecting the compartmental ligand R of the Schiff base for effective binding with a targeted protein, bovine serum albumin (BSA). The most stable hexagonal arrangement of the complex [Zn-Me] (R=Me) stabilises the ligand with the highest FMO energy gap (ΔE=4.

Spectrum of pediatric kidney tumours with special references to WT1 immunostain at a tertiary care hospital.

Context Or Background: Pediatric renal tumours are the second most common solid tumours in children. The most common in this group is Wilms tumour with mesoblastic nephroma being the 2 most common tumour in children, younger than 3 months.

Aims And Objectives: The present study was conducted to study the epidemiological occurrence of pediatric renal tumours at a tertiary care hospital and to study the diagnostic efficacy of WT1 immunostaining in distinguishing Wilms tumour from other types of renal tumours.

Molecular profiling and utility of cell-free DNA in nonsmall carcinoma of the lung: Study in a tertiary care hospital.

Background: Lung carcinoma accounts to the most common cause of cancer globally. Optimal management of nonsmall cell lung carcinoma (NSCLC) requires prognostic biomarkers that help in targeted therapy and identification of tumor subsets with a distinctive molecular profile that can foretell response to therapy. Quantitative analysis of circulating cell-free DNA is considered as a possible aid for lung cancer screening.

Clinicopathological Study of Primary Pediatric Gastrointestinal Lymphomas.

Background: Primary gastrointestinal lymphomas (PGIL) are uncommon in children and account for <5% of all pediatric malignancies. The objective of our study was to analyze the prognostic factors of pediatric PGILs with reference to its histological subtypes, stage, and outcomes using immunohistochemistry.

Materials And Methods: Twenty cases were studied over 11 years.

COVID-19 associated rhino-orbital-cerebral mucormycosis: An observational study from Eastern India, with special emphasis on neurological spectrum.

Aims: 1: Describe the epidemiology and determine risk factors for COVID-19 associated mucormycosis. 2: Elaborate the clinical spectrum of Rhino-Orbital-Cerebral Mucormycosis (ROCM), pattern of neuroaxis involvement and it's radiological correlates.

Methods: Observational study.

Role of EGFR and HER-2/NEU Expression in Gall Bladder Carcinoma (GBC).

 Gall bladder carcinoma (GBC) is the most common malignancy of the biliary tract. Being known for its geographical and racial variations, and compared with the global statistics, its incidence is higher in the Indian subcontinent, mainly in the northern and eastern regions, accounting for 80 to 95% of cases.  This study was conducted to evaluate the clinic-pathological spectrum and expression of EGFR and HER-2/NEU in GBCs and to understand their relation to prognosis, paving the way for targeted therapies for better treatment outcomes and patient survival.

A study on genetic polymorphism of RET proto-oncogene in Hirschsprung's disease in children.

Background: Hirschsprung's disease (HD) is a genetic disorder with a complex pattern of inheritance. Some single-nucleotide polymorphisms (SNPs) are identified to be associated with the risk of Hirschsprung's Disease (HSCR).

Aims And Objectives: The aim of this study is to know the association between the rearranged during transfection (RET) proto-oncogene polymorphism and HD and to characterize the SNPs of RET proto-oncogene affecting HD.

Fabrication of morphologically modified strong supramolecular nanocomposite antibacterial hydrogels based on sodium deoxycholate with inverted optical activity and sustained release.

Low Molecular Weight (LMWG) gelators are small molecules that form supramolecular self-assembly involving physical forces and are highly biocompatible. However, fragility of these physical gels restricts their applicability where gels of higher mechanical strength are required. Herein, we have developed two different types of 2-D carbon nanomaterials viz.

Evaluation of prognostic utility of Ki-67, P53, and O-6-methylguanine-DNA methyltransferase expression in pituitary tumors.

Background Or Context: Pituitary adenoma (PA) is the most common pathology of the pituitary gland. Pituitary tumors were historically considered benign, however, from recent advances in pathological and molecular analyses, numerous prognostic markers have been identified, allowing a better characterization of tumor behavior and prediction of response to treatment and recurrences.

Aims And Objectives: Evaluation of the epidemiological occurrence of pituitary tumors in our center and prediction of the benign, aggressive, or malignant nature of the tumor with the help of immunohistochemical markers (IHC) Ki-67, P53, and O-6-methylguanine-DNA methyltransferase (MGMT) along with radiology.

Prognostic Utility of Cyclin D1 in Invasive Breast Carcinoma.

Invasive breast carcinoma is the most common cancer among women worldwide. Increase in early detection of breast carcinoma by different diagnostic modalities led to decrease in cancer-related mortality and morbidity. Multiple factors and genes are implicated in breast cancer pathogenesis.

Evaluation of diagnostic utility of imprint cytology in paediatric renal tumours with special references to Ki 67 proliferative marker.

Background: Pediatric renal neoplasms comprise about 7%-8% of all neoplasms in children. Wilms tumour (WT) is the most common among pediatric renal tumours.

Aims And Objectives: The study was undertaken to study the epidemiological occurrence of pediatric renal tumours in a tertiary care hospital and to ascertain the validity and reliability of touch smear imprint cytology in intraoperative diagnosis of renal tumours and correlate with subsequent histopathological diagnosis and to assess the expression of proliferation marker Ki-67 in different components and stages of WT.

Dual release kinetics in a single dosage from core-shell hydrogel scaffolds.

The development of drug delivery systems with microencapsulated therapeutic agents is a promising approach to the sustained and controlled delivery of various drug molecules. The incorporation of dual release kinetics to such delivery devices further adds to their applicability. Herein, novel core-shell scaffolds composed of sodium deoxycholate and trishydroxymethylaminomethane (NaDC-Tris) have been developed with the aim of delivering two different drugs with variable release rates using the same delivery vehicle.

Correlations of aldehyde dehydrogenase-1 (ALDH1) expression with traditional prognostic parameters and different molecular subtypes of breast carcinoma.

Background And Aim: Breast cancer, a heterogeneous disease, is the most common cause of cancer-related death in women worldwide. Despite considerable developments in treatment modalities, a subset of patients with advanced-stage breast carcinoma display poor prognosis. Breast cancer heterogeneity and risk of recurrence could be explained with the help of cancer stem cell hypothesis.

Cytodiagnosis of inflammatory myofibroblastic tumor: A report of three cases in infants.

Inflammatory myofibroblastic tumor is a tumor of intermediate grade with a low rate of metastasis. The tumor often mimics malignancy. There is sparse literature available describing the cytological findings of this rare condition.

Delayed primary end-to-end anastomosis for traumatic long segment urethral stricture and its short-term outcomes.

Background:: The purpose of this study is to evaluate the aetiology of posterior urethral stricture in children and analysis of results after delayed primary repair with extensive distal urethral mobilisation.

Materials And Methods: This was a retrospective study carried out in a tertiary care centre from January 2009 to December 2013.

Results:: Eight children with median age 7.

Laparoscopy in the Evaluation of Impalpable Testes and Its Short-term Outcomes: A 7 Years' Experience.

Aims: The aim of this study is to report and analyze results of laparoscopy in impalpable testes performed between 2009 and 2016 and its short-term outcomes.

Materials And Methods: Demographic data, laterality, laparoscopic findings, operative time, procedure, hospital stay, complications, and follow-up data of 76 patients with 79 impalpable testes from 2009 to 2016 were retrospectively collected and analyzed. Successful outcome was defined as maintenance of intrascrotal position with no atrophy at a follow-up of at least 6 months.

Wilms' Tumour in an Adult- A Case Report of an Unusual Lesion.

Wilms' tumour, a renal malignancy, primarily occurs in children with a peak incidence between 2 to 5 years age group and accounts for approximately 95% of childhood renal malignancies. Though rarely, it may also occur in adults with an incidence rate of less than 0.2 per million per year.

Spectrum of meningioma with special reference to prognostic utility of ER,PR and Ki67 expression.

Background: Meningiomas are the most common primary central nervous system neoplasms originating from the arachnoid cap cells and constitute between 13% and 26% of all intracranial tumors.

Aims And Objectives: The aim of the study was to analyze the age-, sex-, and site-wise distribution of different histological patterns of meningiomas seen in our center and to assess the status of estrogen receptor (ER), progesterone receptor (PR), and proliferation marker Ki-67 in various grades of meningioma.

Materials And Methods: A prospective study was done in 90 cases.

Leydig Cell Tumor of Testis in a Child: An Uncommon Presentation.

Leydig cell tumors (LCTs) are rare testicular tumors. Incidence is 1%-3% of all testicular neoplasms, bilateral in 10%. They are frequently hormonally active, leading to feminizing or virilizing syndromes.

Undifferentiated Uterine Sarcoma: An Uncommon Case Report.

Endometrial Stromal Sarcomas (ESS) are rare uterine malignancy of mesodermal origin. A 65-year-old female presented with postmenopausal bleeding in the Department of Gynaecology in our hospital. Computed Topography (CT) revealed an enlarged uterus with areas of low attenuation.