The redox reaction of oxygen (OER & ORR) forms the rate determining step of important processes like cellular respiration and water splitting. Being a spin relaxed process governed by quantum spin exchange interaction, QSEI (the ground triplet state in O is associated with singlet oxygen in HO/OH), its kinetics is sluggish and requires inclusion of selective catalyst. Functionality and sustainability of solid oxide cell involving fuel cell (FC) and electrolyzer cell (EC) are also controlled by ORR (oxygen redox reaction) and OER (oxygen evolution reaction).
View Article and Find Full Text PDFGroup I and II introns are large catalytic RNAs (ribozymes) that are frequently encountered in fungal mitochondrial genomes. The discovery of respiratory mutants linked to intron splicing defects demonstrated that for the efficient removal of organellar introns there appears to be a requirement of protein splicing factors. These splicing factors can be intron-encoded proteins with maturase activities that usually promote the splicing of the introns that encode them (-acting) and/or nuclear-encoded factors that can promote the splicing of a range of different introns (-acting).
View Article and Find Full Text PDFDuring the Mesoproterozoic Era, 1600 to 1000 million years ago, global climate was warm with very little evidence of glaciation. Substantial greenhouse warming would have been required to sustain this ice-free state given 5-18% lower solar luminosity. Paleomagnetic data reported here place voluminous ca.
View Article and Find Full Text PDFThe α CTD (C-terminal domain of the α subunit) of RNA polymerase (RNAP) is a target for transcriptional regulators. In the transcription activation at Class I, Class II, and Class III promoters of bacteria, the transcriptional regulator, binds to DNA at different sites and interacts with the α CTD to stabilize the RNAP at the promoter or it binds to the α CTD to form a prerecruitment complex that searches for its cognate binding site. This 'simple recruitment mechanism' of the transcriptional machinery at the promoter is responsible for the activation of transcription.
View Article and Find Full Text PDFBackground Type 2 diabetes mellitus (T2DM) arises due to a range of pathological abnormalities, necessitating a combination therapy to achieve optimal glycemic control. Vildagliptin, an effective and selective DPP-4 inhibitor, and pioglitazone, an insulin sensitizer, offer distinct mechanisms of action. Hence, the integration of these medications represents a logical and justified therapeutic strategy Objective To compare the efficacy, safety, and tolerability of vildagliptin and pioglitazone 50 mg/15 mg fixed-dose combination (FDC) tablets with individual monotherapy vildagliptin 50 mg and pioglitazone 15 mg tablets in Indian T2DM patients who were inadequately controlled on metformin monotherapy.
View Article and Find Full Text PDFIntroduction: Many members of the Ophiostomatales are of economic importance as they are bark-beetle associates and causative agents for blue stain on timber and in some instances contribute towards tree mortality. The taxonomy of these fungi has been challenging due to the convergent evolution of many traits associated with insect dispersal and a limited number of morphological characters that happen to be highly pleomorphic. This study examines the mitochondrial genomes for three members of [ (also known as ), (also known as ), and sp.
View Article and Find Full Text PDFThe highest exposure of Endocrine disrupting compounds (EDC) into the water bodies as a result of extensive production and application of Covid-19 related drugs is a growing concern now a days. Herein, a novel nanocomposite material was developed by impregnating green synthesized copper oxide nanoparticles on the porous surface of fabric waste derived biochar to eliminate the concerned EDCs along with a sustainable disposal strategy for the spent adsorbent. Morphological characterizations by Field emission scanning electron microscopy confirmed the formation of hierarchical porous structured material.
View Article and Find Full Text PDFHydrogen energy has emerged as the only renewable which is capable of sustaining the prevalent energy crisis in conjunction with other intermittent sources. In this connection, solid oxide cell (SOC) is the most sustainable solid-state devices capable of recycling and reproducing green hydrogen fuel. It is operable in reversible modes viz, fuel cell (FC) and electrolysis cell (EC).
View Article and Find Full Text PDFWe report, for the first time, a detailed crystallographic study of the supramolecular arrangement for a set of zinc(II) Schiff base complexes containing the ligand 2,6-bis((E)-((2-(dimethylamino)ethyl)imino)methyl)-4-R-phenol], where R=methyl/tert-butyl/chloro. The supramolecular study acts as a pre-screening tool for selecting the compartmental ligand R of the Schiff base for effective binding with a targeted protein, bovine serum albumin (BSA). The most stable hexagonal arrangement of the complex [Zn-Me] (R=Me) stabilises the ligand with the highest FMO energy gap (ΔE=4.
View Article and Find Full Text PDF(Schwein.) Fr. (1851) has been reported from North America, Europe, and Asia, and can be a pathogen on various hardwood species.
View Article and Find Full Text PDFCurr Res Pharmacol Drug Discov
February 2022
Background: Gradual increase of multidrug resistant infections is a threat to the human race as MDR plasmids have acquired.>10 mdr and drug efflux genes to inactivate antibiotics. Plants secret anti-metabolites to retard growth of soil and water bacteria and are ideal source of antibiotics.
View Article and Find Full Text PDFCompreHensive Digital ArchiVe of Cancer Imaging - Radiation Oncology (CHAVI-RO) is a multi-tier WEB-based medical image databank. It supports archiving de-identified radiological and clinical datasets in a relational database. A semantic relational database model is designed to accommodate imaging and treatment data of cancer patients.
View Article and Find Full Text PDFIntrons are ubiquitous in eukaryotic genomes and have long been considered as 'junk RNA' but the huge energy expenditure in their transcription, removal, and degradation indicate that they may have functional significance and can offer evolutionary advantages. In fungi, plants and algae introns make a significant contribution to the size of the organellar genomes. Organellar introns are classified as catalytic self-splicing introns that can be categorized as either Group I or Group II introns.
View Article and Find Full Text PDFDevR/DosR response regulator is believed to participate in virulence, dormancy adaptation and antibiotic tolerance mechanisms of Mycobacterium tuberculosis by regulating the expression of the dormancy regulon. We have previously shown that the interaction of DevR with RNA polymerase is essential for the expression of DevR-regulated genes. Here, we developed a M.
View Article and Find Full Text PDFThere are various efforts in de-identifying patient's radiation oncology data for their uses in the advancement of research in medicine. Though the task of de-identification needs to be defined in the context of research goals and objectives, existing systems lack the flexibility of modeling data and normalization of names of attributes for accomplishing them. In this work, we describe a de-identification process of radiation and clinical oncology data, which is guided by a data model and a schema of dynamically capturing domain ontology and normalization of terminologies, defined in tune with the research goals in this area.
View Article and Find Full Text PDFBiochim Biophys Acta Gene Regul Mech
December 2020
AtHMGB15 belongs to a group of ARID-HMG proteins which are plant specific. The presence of two known DNA binding domains: AT rich interacting domain (ARID) and High Mobility Group (HMG)-box, in one polypeptide, makes this protein intriguing. Although proteins containing individual HMG and ARID domains have been characterized, not much is known about the role of ARID-HMG proteins.
View Article and Find Full Text PDFBiomedical data are complex and heterogeneous. An ample reliable quantity of data is important for understanding and exploring the domain. The work aims to integrate biomedical data from various heterogeneous sources like dictionaries or corpus and amalgamate them into a uniform format for easier access by the end-user like biologist, pharmacist, and data scientist.
View Article and Find Full Text PDFWe propose a de-identification system which runs in a standalone mode. The system takes care of the de-identification of radiation oncology patient's clinical and annotated imaging data including RTSTRUCT, RTPLAN, and RTDOSE. The clinical data consists of diagnosis, stages, outcome, and treatment information of the patient.
View Article and Find Full Text PDFAnnu Int Conf IEEE Eng Med Biol Soc
July 2019
The Rorschach inkblot test (RIBT) is a standardized projective technique. It uses a subjective way of collecting and mapping responses of different regions like large (D) and small details (d). In this paper, eye tracking parameters like Initial Fixation Location, SF Ratio, Mean Fixation Duration and Mean Return are used to develop some objective measures which would be helpful in the assessment of the Rorschach responses.
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