Morphological parameters of hepatocytes in the European mole (Talpa europaea) and herb field mouse (Sylvaemus uralensis) under industrial pollution: Qualitative and quantitative assessment.

Morphological alterations of cells and tissues usually occur in biological organisms exposed to environmental contaminants, there by acting as a biomarker of environmental pollution, thus, making this study highly pertinent. The effect of industrial pollution on the qualitative and quantitative morphological parameters of hepatocytes (through histological analysis and cytomorphometry) was studied in two contrasting species of small mammals (Talpa europaea and Sylvaemus uralensis), taking into account the animal age (young and adult groups) and liver concentrations of heavy metals (Cu, Zn, Cd, Pb). Studies were performed in the regions exposed to emissions from two currently operating copper smelters: Middle Ural Copper Smelter (Middle Urals, T.

Small mammals of background areas in the vicinity of the Karabash copper smelter (Southern Urals, Russia).

Background: The dataset contains records of small mammals (Eulipotyphla and Rodentia) collected in the background (unpolluted) areas in the vicinity of Karabash copper smelter (Southern Urals, Russia) and the territory of the Sultanovskoye deposit of copper-pyrite ores before the start of its development. Data were collected during the snowless periods in 2007 (18 sampling plots), 2008-2010 (13 plots annually), 2011 (30 plots) and 2012-2014 (19 plots annually). The capture of animals was carried out in different types of forests (pine, birch, mixed and floodplain), sparse birch stands, reed swamps, marshy and dry meadows, border areas, a household waste dump, areas of ruderal vegetation and a temporary camp.

[qSOFA score for prediction of outcome in surgical patients in intensive care units. Post hoc analysis of the Russian multi-center trial Rises].

Objective: To define the informative value of qSOFA score in the prediction of outcomes in surgical patients admitted to the Intensive Care Units.

Study Design: Post hoc analysis of multicenter prospective observational study RISES. The following patient information was analyzed: gender, age, diagnosis, presence of infection, SIRS criteria, qSOFA and SOFA scores, outcomes.

CLINICAL CASE OF THE INNATE CENTRAL HYPOVENTILATION SYNDROME IN THE PARTURIENT.

The syndrome "of the curse of Undina" or the innate central hypoventilation syndrome with the second disorder of cen- tral nervous system is the result of the disrupted vegetative control of the respiration in the absence of neuromuscular diseases and disturbances of the mechanics of respiration. In the clinical practice diagnostics of this state is complex, frequently the cases remain not diagnosed. Taking into account clinical manifestations and depending on the degree of their intensity, early diagnostics, which warns the undesirable consequences ofthe episodes ofhypoxia and hypercapnia, that ensures the proper checking of the episodes of asphyxia, determines not only the forecast of disease, but also life of patient.

[Blood system peculiarities in the bank vole (Clethrionomys glareolus) under chronic environmental pollution].

The parameters of peripheral blood and hemopoietic organs in mature and immature bank voles inhabiting a chemically polluted area were studied. Variability of the blood system parameters depending on the level of toxic load and the animals' reproductive status was determined. Alteration of the cell composition of erythrocytes and leucocytes, the structure of erythrocytes, and the hemoglobin fractions and leucocyte functions describe the adaptive response to the factors of a changed environment more than the concentration of leucocytes, erythrocytes, and blood hemoglobin.

[Multicentre study of comparative efficacy of meropenem and combined regimens for empirical antibacterial therapy of severe nosocomial infections: results of clinical and pharmacoeconomic analysis].

Adequacy and effectiveness of empirical antibacterial therapy of severe nosocomial infections with meropenem vs. combined regimens of antibacterial therapy were investigated and the ratio of the cost and effectiveness of the compared regimens was evaluated. A prospective, randomized, open, comparative study of two initiative regimens of empirical antibacterial therapy of severe nosocomial infections was performed: meropenem in a daily dose of 1.