SnCl-catalyzed multicomponent coupling: synthesis of 1,3-oxazolidine derivatives using paraformaldehyde as a C1 feedstock.

SnCl catalyzed the three-component coupling of aniline, epoxide, and paraformaldehyde, resulting in the synthesis of 1,3-oxazolidine derivatives. The reaction is simple and does not require any additives, bases, or oxidants, and proceeds at moderate temperature with good functional group tolerance. The scope of the utilization of paraformaldehyde as the methylene source was further extended to the synthesis of benzothiazole and 4,4'-methylenebis(,-dimethylaniline) using the same catalyst.

Aminocarbonylation Reaction Using a Pd-Sn Heterobimetallic Catalyst: Three-Component Coupling for Direct Access of the Amide Functionality.

A heterobimetallic "Pd-Sn" catalyst, namely, PdCl(PPh)SnCl, efficiently catalyzes the aminocarbonylation reaction of aryl iodides with amines under the atmospheric pressure of CO in the absence of a base and additive. Primary, secondary, and alkyl amines all afforded the corresponding amides in good to excellent yields with high selectivity. A broad range of functional groups were tolerated.

A Pd-Sn heterobimetallic catalyst for carbonylative Suzuki, Sonogashira and aminocarbonylation reactions using chloroform as a CO surrogate.

Herein, we report a heterobimetallic Pd-Sn catalyst for the carbonylative Suzuki coupling, aminocarbonylation reaction, and carbonylative Sonogashira coupling of aryl halides with boronic acids, amines, and aromatic alkynes leading to a three-component coupling reaction using generated carbon monoxide. Under the optimized reaction conditions, a variety of bisaryl ketones, amides, and aromatic ynones have been synthesized in moderate to good yields in a one-pot fashion. The reported catalyst has wide reaction scope with good functional group tolerance.