Publications by authors named "Mukesh Kumar Jogi"
Cold-inducible RNA-binding protein (CIRP) is a versatile RNA-binding protein, pivotal in modulating cellular responses to diverse stress stimuli including cold shock, ultraviolet radiation, hypoxia, and infections, with a principal emphasis on cold stress. The temperature range of 32-34 °C is most suitable for CIRP expression. The human CIRP is an 18-21 kDa polypeptide containing 172 amino acids coded by a gene located on chromosome 19p13.
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- - The study focuses on the mutations in the spike (S) protein of SARS-CoV-2 omicron variants found in Delhi, India, highlighting their role in increased transmissibility and potential immune evasion due to changes in binding to the ACE-2 receptor.
- - Key mutations such as Y505 reversion, G339H, and R346T/N are associated with altered immune responses and antibody neutralization abilities, indicating a partial immune escape by the omicron variant.
- - Researchers are investigating various strategies to improve vaccine efficacy against these variants, including modifications to existing vaccines, developing multi-strain formulations, and understanding the implications of mutations on immune recognition and interaction with antibodies.