Impact of the COVID-19 pandemic on treatment of patients with acute myeloid leukaemia in India.

During the COVID-19 pandemic, our findings highlight changes in AML management strategies in India. There was a decrease in overall patient registrations, particularly at large referral centers, while smaller centers saw an increase, reflecting a shift towards more localized care. This shift was accompanied by a rise in the use of hypomethylating agents (HMAs).

Mapping Educational uncertainty stimuli to support health professions educators' in developing learner uncertainty tolerance.

Uncertainty is a feature of healthcare practice. In recognition of this, multiple health profession governing bodies identify uncertainty tolerance as a healthcare graduate attribute and evaluate uncertainty tolerance within new graduate cohorts. While it is clear that uncertainty tolerance development for healthcare learners is valued, gaps remain for practically addressing this within healthcare curricula.

Healing After Horizontal Root Fracture of Maxillary Central Incisor: A Case Report With 24-Month Follow-Up.

Facial traumatic injuries are quite common, resulting in the fracture and displacement of tooth and/or bone fragments. Loss of tooth structure may have lifetime consequences for the patient. Horizontal root fractures (HRFs) may occur in the maxillary anterior teeth at different locations, showing varied patterns of healing.

Controlling the transmission of broadband light through scattering media using a digital micromirror device.

Wavefront shaping has emerged as a valuable technique in complex photonics, wherein the various eigenmodes of the disordered medium are selectively excited to control the overall transmission through the medium. The process utilizes active optical devices such as liquid crystal-based spatial light modulators (LC-SLM), deformable mirrors (DM), and digital micromirror devices (DMD). Among these, the latter is preferred for imaging through dynamic scattering media such as living biological tissues due to their high-speed refresh rate and increased resolution.

Production and characterization of bioemulsifier by .

The current study evaluated MCC 2546 for its potential to produce a bioemulsifier (BE). Screening methods performed for BE production by MCC 2546 showed good lipase activity, positive drop collapse test, and oil-spreading activity. Furthermore, it showed maximum emulsification activity (225 EU/ml) and emulsification index (E 50%) at 37°C in Luria Bertani broth at 72 h with olive oil as a substrate.

Cholestatic Liver Injury in a Patient with Tertiary Syphilis.

Syphilis is a common infection that has variable presentations. We report a rare case of a 64-year-old male with 3 weeks of abdominal pain, back pain, and neurologic deficits including memory impairment who was found to have neurosyphilis causing a cholestatic liver injury. Workup included a positive rapid plasma reagin (RPR) and enzyme immunoassay (EIA), a positive cerebrospinal fluid (CSF) venereal disease research laboratory (VDRL), and a liver biopsy, which was compatible with a diagnosis of syphilitic hepatitis.

Medication cost-reducing behaviors in older adults with atrial fibrillation: The SAGE-AF study.

Background: As patient prices for many medications have risen steeply in the United States, patients may engage in cost-reducing behaviors (CRBs) such as asking for generic medications or purchasing medication from the Internet.

Objective: The objective of this study is to describe patterns of CRB, cost-related medication nonadherence, and spending less on basic needs to afford medications among older adults with atrial fibrillation (AF) and examine participant characteristics associated with CRB.

Methods: Data were from a prospective cohort study of older adults at least 65 years with AF and a high stroke risk (CHADSVASc ≥ 2).

Successful Treatment With Daptomycin of MRSA Empyema Complicated by Right-Sided Loculated Pleural Effusion Refractory to Vancomycin.

Empyema is a serious complication of pneumonia and has been reported to have a mortality rate of 8.7%. For methicillin-resistant (MRSA) empyema, treatment includes drainage and specific antibiotics such as vancomycin and linezolid.

Intensity-dependent speckle contrast of second harmonic light in a nonlinear disordered medium.

Coherent light propagation and scattering in diffuse media realize an interference effect that manifests as a random spatial distribution of bright and dark spots called speckle. Laser speckle contrast is a crucial parameter that quantifies light behavior in diffuse media, often of help in biomedical imaging applications. With several ultra-intense lasers coming onto the scene in recent years, the probability of nonlinearly generating harmonic light has considerably increased.

Challenges and opportunities to include patient-centric product design in industrial medicines development to improve therapeutic goals.

In the past, drug developers in industry chose approaches mainly focusing on the drug product's efficacy, safety and quality according to the level required by regulatory expectations stipulated in guidelines, pharmacopoeia and other regulatory provisions. By putting more focus on the patient perspective, regulatory authorities are currently raising their requirements regarding successful product submissions. The increasing involvement of patients in the product development process (e.

Sustaining the Gains: A 7-Year Follow-Through of a Hospital-Wide Patient Safety Improvement Project on Hospital-Wide Adverse Event Outcomes and Patient Safety Culture.

Objectives: Adverse events (AEs) remain a challenge in tertiary healthcare with incidence rates of 4% to 14%, where half are potentially preventable. Reported patient safety strategies rarely involve changing the practices of an entire academic institution and maintaining sustainability. We hypothesize that implementing an effective patient safety strategy (PSS) improves hospital-wide AE rates, cost avoidance, and patient safety culture.

Reduction in generalized conductance with increasing gain in amplifying Anderson-localized systems.

The consequences of a nonconservative environment on the transport of photons under conditions of Anderson localization in a disordered system are a topic of great interest. In this work, we experimentally demonstrate the systematic decrease in the localization length of a quasi-one-dimensional localizing system when gain is added to it. We quantify the generalized conductance of the system using the variance of the fluctuations in the localized eigenfunctions and show a decrease in conductance with gain.

Necklace-State-Mediated Anomalous Enhancement of Transport in Anderson-Localized non-Hermitian Hybrid Systems.

Non-Hermiticity is known to manifest interesting modifications in the transport properties of complex systems. We report an intriguing regime of transport of hybrid quasiparticles in a non-Hermitian setting. We calculate the probability of transport, quantified by the Thouless conductance, of hybrid plasmons under varying degrees of disorder.

Relation between the localization length and level repulsion in 2D Anderson localization.

We report on the relation between the localization length and level-spacing characteristics of two-dimensional (2D) optical localizing systems. Using the tight-binding model over a wide range of disorder, we compute spectro-spatial features of Anderson localized modes. The spectra allow us to estimate the level-spacing statistics while the localization length $ \xi $ξ is computed from the eigenvectors.

Swelling, Mechanics, and Thermal/Chemical Stability of Hydrogels Containing Phenylboronic Acid Side Chains.

We report here studies of swelling, mechanics, and thermal stability of hydrogels consisting of 20 mol % methacrylamidophenylboronic acid (MPBA) and 80 mol % acrylamide (AAm), lightly crosslinked with methylenebisacrylamide (Bis). Swelling was measured in solutions of fixed ionic strength, but with varying pH values and fructose concentrations. Mechanics was studied by compression and hold.

Production, characterization, and applications of bioemulsifiers (BE) and biosurfactants (BS) produced by Acinetobacter spp.: A review.

Bioemulsifiers (BE) and biosurfactants (BS) are considered as multifunctional biomolecules of 21 century because of their functional abilities and eco-friendly properties. They are produced by various microorganisms under versatile and extreme environmental conditions. They have tremendous applications in various industries such as petroleum, food, medicine, pharmaceutical, chemical, paper & pulp, textile, and cosmetics.

Self-Assembled Photonic Crystals of Monodisperse Dendritic Fibrous Nanosilica for Lasing: Role of Fiber Density.

Photonic crystals are essentially a periodic ("crystalline") arrangement of dielectric nanoparticles that respond in unison to incident light. They can be used to harvest light in various applications such as photocatalysis, solar cells, and lasing. In this work, we prepared the photonic crystals of dendritic fibrous nanosilica (DFNS) by their self-assembly.

Direct observation of Anderson localization in plasmonic terahertz devices.

We present the first experimental observation of Anderson localization in the terahertz frequency range using plasmonic structures. To accomplish this goal, we designed THz waveguides consisting of a one-dimensional array of rectangular apertures that were fabricated in a freestanding metal foil. Disorder is introduced into the waveguide by offsetting the position of each aperture by a random distance within a prescribed range.

Effectiveness of a Web-Based Simulation in Improving Nurses' Workplace Practice With Deteriorating Ward Patients: A Pre- and Postintervention Study.

Background: Nurses play an important role in detecting patients with clinical deterioration. However, the problem of nurses failing to trigger deteriorating ward patients still persists despite the implementation of a patient safety initiative, the Rapid Response System. A Web-based simulation was developed to enhance nurses' role in recognizing and responding to deteriorating patients.

Physical manifestation of extreme events in random lasers.

We report our studies on exponentially-tempered Lévy sums that explain coherent random lasers based on nonresonant feedback. We investigate the hierarchy in the sums and identify the contribution of the extremes over a wide range of excitation energies and disorder strengths. Subsequently, we carry out experiments in which the physical manifestation of these extremes is revealed.

Self-amplification of supercritical angle fluorescence using multiple emitters at a dielectric-dielectric interface.

Super-critical angle fluorescence (SAF) generated from an ensemble of emitters overlying a high-contrast dielectric-dielectric interface is discussed. At increased excitation, signatures of self-amplification of the SAF were observed, which differed from the emission properties of normal fluorescence generated within the critical angle. Contrasting behavior was observed between the SAF and normal fluorescence with respect to bandwidth narrowing for varying gain lengths.

Exponentially tempered Lévy sums in random lasers.

Lévy fluctuations have associated infinities due to diverging moments, a problem that is circumvented by putting restrictions on the magnitude of the fluctuations, realizing a process called the truncated Lévy flight. We show that a perfect manifestation of this exotic process occurs in coherent random lasers, and it turns out to be the single underlying explanation for the complete statistical behavior of nonresonant random lasers. A rigorous parameter estimation of the number of summand variables, the truncation parameter, and the power-law exponent is carried out over a wide range of randomness, inversion, and system size.

Teamwork and communication: an effective approach to patient safety.

Teamwork and communication failures are leading causes of patient safety incidents in health care. Though health care providers must work in teams, they are not well-trained in teamwork and communication skills. Health care faces the problems of differences in communication styles, communication failures and poor teamwork.