Association of Treatment Duration and Clinical Outcomes in Dry Eye Treatment with Sutureless Cryopreserved Amniotic Membrane.

Background: While sutureless, cryopreserved amniotic membrane (cAM) has been shown to significantly improve signs and symptoms of dry eye disease (DED), no studies have assessed the association of cAM treatment duration to the differential response in clinical outcomes.

Methods: A multi-center, retrospective study was conducted on patients with moderate-to-severe DED who were treated with self-retained cAM (Prokera Slim) for 2 to 7 days. The primary outcome measure was DEWS severity score assessed at 1 week, 1 month, and 3 months.

The Influence of Tomographic Corneal Characteristics on Epithelial Thickness Profile.

Purpose To understand the influence of tomographic corneal characteristics on the epithelium of normal eyes. Methods We scanned a total of 98 eyes of 98 individuals using anterior segment tomography and a spectral-domain optical coherence tomography (OCT) epithelial mapping tool. Only eyes with no previous pathology were included, with a refractive range of +5 diopters (D) to -6 D, intraocular pressure of < 22 mmHg, and no evidence of dry eye (Schirmer's test 2 value > 5 mm).

Objective Quantification of Image Quality and Optical Scatter Before and After Nd:YAG Capsulotomy Using a Double-Pass Technique.

Purpose: The purpose of this study is to evaluate and compare the correlation between changes in vision and HD Analyzer dual-pass metrics versus changes in vision and conventional subjective slit lamp gradings in pseudophakic patients with posterior capsular opacity undergoing neodymium:yttrium-aluminum-garnet (Nd:YAG) capsulotomy.

Patients And Methods: High contrast (HC) and low contrast (LC) best spectacle-corrected distance visual acuity (BCVA) and HD Analyzer evaluation were prospectively performed on patients with mild-to-moderate posterior capsular opacification (PCO) and monofocal and accommodating intraocular lens implants. Differences between pre- and post-operative measurements were calculated, along with the correlation of HD Analyzer metrics and slit lamp grading to changes in visual acuity.

Longitudinal changes in dry eye symptoms and signs following lifitegrast therapy and relationship to tear osmolarity.

Background: This study measured longitudinal changes in dry eye disease (DED) symptoms and signs following lifitegrast therapy and assessed their relationship to tear osmolarity to test the hypothesis that a decline in tear osmolarity is a reliable leading indicator of subsequent improvement in DED symptoms and signs after initiating lifitegrast treatment.

Methods: This phase IV, prospective, single-arm, open-label, 12-week study enrolled subjects aged ≥18 years with eye dryness score ≥40 (0-100 VAS) and tear osmolarity ≥308 mOsm/L. Subjects were prescribed lifitegrast ophthalmic solution 5%, twice daily in each eye.

Analysis of cases and accuracy of 3 risk scoring systems in predicting ectasia after laser in situ keratomileusis.

Purpose: To identify risk factors for ectasia after laser in situ keratomileusis (LASIK) by comparing the accuracy of the Ectasia Risk Score System (ERSS), Screening Corneal Objective Risk of Ectasia (SCORE) Analyzer, and percentage of tissue altered (PTA) in predicting the occurrence of ectasia.

Setting: Multiple centers in 8 countries.

Design: Retrospective case series.

Treatment outcomes in the DRy Eye Amniotic Membrane (DREAM) study.

Purpose: To evaluate the efficacy of cryopreserved amniotic membrane (CAM) in reducing signs and symptoms of dry eye disease (DED) in a large patient population.

Methods: A retrospective chart review at 10 clinical sites was done of patients with refractory DED who received CAM and completed at least 3 months of follow-up. Data collected were demographics; medical history including previous and current ocular treatment, diagnosis, clinical presentations, comorbidity, duration and frequency of treatment with CAM; and concomitant medications.

Accommodating Intraocular Lenses.

With an explosive increase in the worldwide prevalence of presbyopia, development of an accommodating intraocular lens (IOL) with expansive accommodative amplitude remains the holy grail in lens-based refractive surgery. A dynamic change in the dioptric power of the eye can be accomplished by various strategies alone or in combination, including changes in the position, shape, or refractive index of a single- or dual- optic IOL. This article reviews the cumulative advances in these various lens designs, along with clinical outcomes and complications of those that have been implanted.

Benefits and barriers of accommodating intraocular lenses.

Purpose Of Review: Presbyopia and cataract development are changes that ubiquitously affect the aging population. Considerable effort has been made in the development of intraocular lenses (IOLs) that allow correction of presbyopia postoperatively. The purpose of this review is to examine the benefits and barriers of accommodating IOLs, with a focus on emerging technologies.

A prospective randomized clinical evaluation of 3 presbyopia-correcting intraocular lenses after cataract extraction.

Purpose: To compare contrast sensitivity, visual acuity (VA), and halos in subjects bilaterally implanted with 1 of 3 FDA-approved presbyopia-correcting intraocular lenses.

Design: Prospective, randomized, partially masked, multicenter clinical trial.

Methods: Seventy-eight subjects were randomized sequentially for bilateral implantation with the Crystalens AO (Bausch & Lomb Surgical), AcrySof IQ ReSTOR +3.

Postoperative changes in intraocular pressure and corneal biomechanical metrics Laser in situ keratomileusis versus laser-assisted subepithelial keratectomy.

Purpose: To compare intraocular pressure (IOP) and corneal biomechanical metric changes after myopic laser in situ keratomileusis and laser-assisted subepithelial keratectomy (LASEK).

Setting: Private practice, St. Louis, Missouri, USA.

Novel objective method for comparing ablation centration with and without pupil tracking following myopic laser in situ keratomileusis using the bausch & lomb technolas 217A.

Purpose: To apply an objective method to topographically determine functional optical zone (TFOZ) dimensions in order to compare ablation centration, and refractive outcomes, following myopic laser in situ keratomileusis (LASIK) with and without automated, infrared (IR) pupil tracking.

Methods: Thirty-seven eyes that underwent LASIK using the Technolas 217A with active IR pupil tracking (IT) were retrospectively compared to 37 matched eyes treated with manual tracking (MT). Visual acuity, refractive error, and corneal topography were measured pre- and postoperatively.

Comparison of contrast sensitivity, depth of field and ocular wavefront aberrations in eyes with an IOL with zero versus positive spherical aberration.

Purpose: To compare the clinical performance of the zero spherical aberration (SA) SofPort LI61AO (AO, Bausch & Lomb) intraocular lens (IOL) to the AcrySof SA60AT (AT, Alcon), which has positive spherical aberration.

Methods: Patients underwent uneventful phacoemulsification with implantation of either an aspheric (AO, n = 19) or spherical (AT, n = 20) IOL. Postoperatively, a 5 mm artificial pupil was positioned in trial frames with the cycloplegic refraction during monocular, mesopic contrast sensitivity (CSF) and low-contrast visual acuity (LCVA) testing with glare.

Biometry and intraocular lens power calculation.

Purpose Of Review: Heightened patient expectations for precise postoperative refractive results have spurred the continued improvements in biometry and intraocular lens calculations. In order to meet these expectations, attention to proper patient selection, accurate keratometry and biometry, and appropriate intraocular lens power formula selection with optimized lens constants are required. The article reviews recent studies and advances in the field of biometry and intraocular lens power calculations.

Comparative performance of the Zyoptix XP and Hansatome zero-compression microkeratomes.

Purpose: To compare flap parameters produced by the Zyoptix XP and Hansatome microkeratomes (both Bausch & Lomb) and to evaluate preoperative variables contributing to flap thickness variation.

Setting: Private practice, St. Louis, Missouri, USA.

Visual performance of patients with bilateral vs combination Crystalens, ReZoom, and ReSTOR intraocular lens implants.

Purpose: To compare the visual performance of patients with bilateral vs combination Crystalens, ReZoom, and ReSTOR intraocular lens (IOLs) implants.

Design: Prospective, nonrandomized study.

Methods: Forty-nine patients were implanted with bilateral Crystalens (Eyeonics, Aliso Viejo, California, USA), ReSTOR (Alcon Laboratories, Fort Worth, Texas, USA), and ReZoom (American Medical Optics, Santa Clara, California, USA) or combined Crystalens and ReSTOR or Crystalens and ReZoom IOLs after phacoemulsification.

Determining corneal power using Orbscan II videokeratography for intraocular lens calculation after excimer laser surgery for myopia.

Purpose: To assess the accuracy of Orbscan II slit-scanning videokeratography for intraocular lens (IOL) calculation in eyes with previous photorefractive surgery for myopia.

Setting: Private practice, St. Louis, Missouri, USA.

Changes in corneal biomechanics and intraocular pressure following LASIK using static, dynamic, and noncontact tonometry.

Purpose: To compare the preoperative and postoperative measurement of corneal biomechanical properties and intraocular pressure (IOP) using Goldmann applanation tonometry (GAT), the ocular response analyzer (ORA), and the Pascal dynamic contour tonometer (PDCT) in eyes undergoing myopic laser in situ keratomileusis (LASIK).

Design: Prospective, nonrandomized clinical trial.

Methods: IOP was measured in 66 myopic eyes before and after LASIK by GAT, ORA, and PDCT in a randomized sequence.

Development of late-onset subepithelial corneal haze after laser-assisted subepithelial keratectomy with prophylactic intraoperative mitomycin-C Case report and literature review.

We present a case of dense, visually significant reticular haze that developed approximately 17 months after uneventful laser-assisted subepithelial keratectomy with mitomycin-C (MMC). The patient was successfully treated with manual debridement coupled with phototherapeutic keratectomy and intraoperative MMC.

Topographic and biomechanical differences between hyperopic and myopic laser in situ keratomileusis.

Purpose: To evaluate the size, shape, and uniformity of the videokeratographic functional optical zone (FOZ) after laser in situ keratomileusis (LASIK) in 2 cohorts of patients with equivalent amounts of preoperative myopic or hyperopic astigmatism.

Setting: Pepose Vision Institute, St. Louis, Missouri, USA.

Treatment of dense subepithelial corneal haze after laser-assisted subepithelial keratectomy.

We report a case of dense and visually significant corneal haze after laser-assisted subepithelial keratectomy (LASEK). Visually significant corneal haze after LASEK can be successfully treated with manual debridement and intraoperative mitomycin-C.

The effect of punctal occlusion on wavefront aberrations in dry eye patients after laser in situ keratomileusis.

Purpose: To compare the wavefront aberrations in post-laser in situ keratomileusis (LASIK) dry eye patients before and after punctal occlusion.

Design: Prospective, comparative, nonrandomized study.

Methods: Wavefront aberrometry was performed on 16 eyes of eight patients with dry eyes after LASIK surgery.

Intraocular lens calculations in patients with corneal scarring and irregular astigmatism.

Purpose: To compare various methods of estimating corneal power for intraocular lens (IOL) calculation in patients with irregular corneal astigmatism.

Setting: Pepose Vision Institute, St. Louis, Missouri, USA.

Implantation of scleral expansion band segments for the treatment of presbyopia.

Purpose: To assess the effects of scleral expansion band (SEB) segments on accommodative amplitude (primary measure), along with near and distance vision, refraction, pupil size and function, keratometry, axial length, intraocular pressure, contrast sensitivity, stereopsis, and other parameters (secondary measures) in a cohort of 29 emmetropic, presbyopic patients.

Design: Multicenter, prospective, nonrandomized, unmasked clinical trial in which the nonoperated eye served as the control.

Methods: Four polymethylmethacrylate segments were surgically implanted in quadrantic scleral pockets created in the dominant eye of 29 emmetropic patients who were between the ages of 51 and 60 (mean age 54).